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Protein

Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase C144.17c

Gene

SPAC144.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Synthesis and degradation of fructose 2,6-bisphosphate.By similarity

Catalytic activityi

Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116Fructose 6-phosphateBy similarity1
Active sitei142Sequence analysis1
Binding sitei144Fructose 6-phosphateBy similarity1
Binding sitei207Fructose 6-phosphateBy similarity1
Binding sitei408Fructose 2,6-bisphosphateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 67ATPBy similarity9
Nucleotide bindingi181 – 186ATPBy similarity6
Nucleotide bindingi359 – 362ATPBy similarity4
Nucleotide bindingi404 – 408ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase C144.17c
Including the following 2 domains:
6-phosphofructo-2-kinase (EC:2.7.1.105)
Fructose-2,6-bisphosphatase (EC:3.1.3.46)
Gene namesi
ORF Names:SPAC144.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC144.17c.
PomBaseiSPAC144.17c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003184931 – 449Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase C144.17cAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UTK9.
PRIDEiQ9UTK9.

PTM databases

iPTMnetiQ9UTK9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi279338. 34 interactors.
MINTiMINT-4710714.

Structurei

3D structure databases

ProteinModelPortaliQ9UTK9.
SMRiQ9UTK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni261 – 410Fructose-2,6-bisphosphataseBy similarityAdd BLAST150

Sequence similaritiesi

In the C-terminal section; belongs to the phosphoglycerate mutase family.Curated

Phylogenomic databases

InParanoidiQ9UTK9.
OMAiRTRRILY.
OrthoDBiEOG092C2IWP.
PhylomeDBiQ9UTK9.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10606. PTHR10606. 1 hit.
PfamiPF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
[Graphical view]
PRINTSiPR00991. 6PFRUCTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRNSIAVE QAINPNMLRA ANRSSEALLD NEKFGGVQPY STESGMLFHA
60 70 80 90 100
GKLVIIMSGL PARGKSNIAV SIDRYLRWLG FNCRFYSLAK YIDERTREMT
110 120 130 140 150
SSPVKSAASE NHVFSRNDTI ERCLADLEIF LLKEKGQVAI YDATNGTRRT
160 170 180 190 200
RRILYDRFKN CGFKILFIES LCNKEDVINA NIQEAIHVSE EFRNWDLEMA
210 220 230 240 250
EKEYCRRIDI LKCHYETIDE KDYSFVKMIN FAETIIANKS NEGYLLSRIL
260 270 280 290 300
FLLMNMTLAR KRIFLVPKAS MRPLKLREPE DDIENRQFSE YVADRIRKSF
310 320 330 340 350
PDVSFKNLHV LSCMEDSVMS PFRELGSVTS SMSSLSPILM DSFGDDLQKL
360 370 380 390 400
KETYGEEEYN LYLVDPYRYR VKRKESFYDL AVRLEPLILE LGREQRDVLL
410 420 430 440
IGSKSIIRVF YGYYMNVPAK DIPQLCLSSS SIYELIESST GMTVNEYDL
Length:449
Mass (Da):52,011
Last modified:September 22, 2009 - v2
Checksum:i4E6ED9A4C0617349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59697.2.
PIRiT37684.
RefSeqiNP_594678.2. NM_001020107.3.

Genome annotation databases

EnsemblFungiiSPAC144.17c.1; SPAC144.17c.1:pep; SPAC144.17c.
GeneIDi2542894.
KEGGispo:SPAC144.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59697.2.
PIRiT37684.
RefSeqiNP_594678.2. NM_001020107.3.

3D structure databases

ProteinModelPortaliQ9UTK9.
SMRiQ9UTK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279338. 34 interactors.
MINTiMINT-4710714.

PTM databases

iPTMnetiQ9UTK9.

Proteomic databases

MaxQBiQ9UTK9.
PRIDEiQ9UTK9.

Protocols and materials databases

DNASUi2542894.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC144.17c.1; SPAC144.17c.1:pep; SPAC144.17c.
GeneIDi2542894.
KEGGispo:SPAC144.17c.

Organism-specific databases

EuPathDBiFungiDB:SPAC144.17c.
PomBaseiSPAC144.17c.

Phylogenomic databases

InParanoidiQ9UTK9.
OMAiRTRRILY.
OrthoDBiEOG092C2IWP.
PhylomeDBiQ9UTK9.

Miscellaneous databases

PROiQ9UTK9.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10606. PTHR10606. 1 hit.
PfamiPF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
[Graphical view]
PRINTSiPR00991. 6PFRUCTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIVH_SCHPO
AccessioniPrimary (citable) accession number: Q9UTK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.