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Protein

Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase C144.17c

Gene

SPAC144.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Synthesis and degradation of fructose 2,6-bisphosphate.By similarity

Catalytic activityi

Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Fructose 6-phosphateBy similarity
Active sitei142 – 1421Sequence analysis
Binding sitei144 – 1441Fructose 6-phosphateBy similarity
Binding sitei207 – 2071Fructose 6-phosphateBy similarity
Binding sitei408 – 4081Fructose 2,6-bisphosphateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 679ATPBy similarity
Nucleotide bindingi181 – 1866ATPBy similarity
Nucleotide bindingi359 – 3624ATPBy similarity
Nucleotide bindingi404 – 4085ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase C144.17c
Including the following 2 domains:
6-phosphofructo-2-kinase (EC:2.7.1.105)
Fructose-2,6-bisphosphatase (EC:3.1.3.46)
Gene namesi
ORF Names:SPAC144.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC144.17c.
PomBaseiSPAC144.17c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase C144.17cPRO_0000318493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UTK9.

PTM databases

iPTMnetiQ9UTK9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi279338. 34 interactions.
MINTiMINT-4710714.

Structurei

3D structure databases

ProteinModelPortaliQ9UTK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni261 – 410150Fructose-2,6-bisphosphataseBy similarityAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the phosphoglycerate mutase family.Curated

Phylogenomic databases

InParanoidiQ9UTK9.
OMAiCRRIDIL.
OrthoDBiEOG7B05NZ.
PhylomeDBiQ9UTK9.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10606. PTHR10606. 1 hit.
PfamiPF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
[Graphical view]
PRINTSiPR00991. 6PFRUCTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRNSIAVE QAINPNMLRA ANRSSEALLD NEKFGGVQPY STESGMLFHA
60 70 80 90 100
GKLVIIMSGL PARGKSNIAV SIDRYLRWLG FNCRFYSLAK YIDERTREMT
110 120 130 140 150
SSPVKSAASE NHVFSRNDTI ERCLADLEIF LLKEKGQVAI YDATNGTRRT
160 170 180 190 200
RRILYDRFKN CGFKILFIES LCNKEDVINA NIQEAIHVSE EFRNWDLEMA
210 220 230 240 250
EKEYCRRIDI LKCHYETIDE KDYSFVKMIN FAETIIANKS NEGYLLSRIL
260 270 280 290 300
FLLMNMTLAR KRIFLVPKAS MRPLKLREPE DDIENRQFSE YVADRIRKSF
310 320 330 340 350
PDVSFKNLHV LSCMEDSVMS PFRELGSVTS SMSSLSPILM DSFGDDLQKL
360 370 380 390 400
KETYGEEEYN LYLVDPYRYR VKRKESFYDL AVRLEPLILE LGREQRDVLL
410 420 430 440
IGSKSIIRVF YGYYMNVPAK DIPQLCLSSS SIYELIESST GMTVNEYDL
Length:449
Mass (Da):52,011
Last modified:September 22, 2009 - v2
Checksum:i4E6ED9A4C0617349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59697.2.
PIRiT37684.
RefSeqiNP_594678.2. NM_001020107.3.

Genome annotation databases

EnsemblFungiiSPAC144.17c.1; SPAC144.17c.1:pep; SPAC144.17c.
GeneIDi2542894.
KEGGispo:SPAC144.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59697.2.
PIRiT37684.
RefSeqiNP_594678.2. NM_001020107.3.

3D structure databases

ProteinModelPortaliQ9UTK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279338. 34 interactions.
MINTiMINT-4710714.

PTM databases

iPTMnetiQ9UTK9.

Proteomic databases

MaxQBiQ9UTK9.

Protocols and materials databases

DNASUi2542894.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC144.17c.1; SPAC144.17c.1:pep; SPAC144.17c.
GeneIDi2542894.
KEGGispo:SPAC144.17c.

Organism-specific databases

EuPathDBiFungiDB:SPAC144.17c.
PomBaseiSPAC144.17c.

Phylogenomic databases

InParanoidiQ9UTK9.
OMAiCRRIDIL.
OrthoDBiEOG7B05NZ.
PhylomeDBiQ9UTK9.

Miscellaneous databases

PROiQ9UTK9.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10606. PTHR10606. 1 hit.
PfamiPF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
[Graphical view]
PRINTSiPR00991. 6PFRUCTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiYIVH_SCHPO
AccessioniPrimary (citable) accession number: Q9UTK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 22, 2009
Last modified: June 8, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.