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Q9UTK3

- NPT1_SCHPO

UniProt

Q9UTK3 - NPT1_SCHPO

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Protein

Probable nicotinate phosphoribosyltransferase

Gene

SPAC1486.06

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: PomBase

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
ORF Names:SPAC1486.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1486.06.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Probable nicotinate phosphoribosyltransferasePRO_0000205861Add
BLAST

Proteomic databases

MaxQBiQ9UTK3.

Interactioni

Protein-protein interaction databases

MINTiMINT-4710681.
STRINGi4896.SPAC1486.06-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
InParanoidiQ9UTK3.
KOiK00763.
OMAiDWTYEGQ.
OrthoDBiEOG71K6C8.
PhylomeDBiQ9UTK3.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEPAVVSIL DTDLYKLTML QAVLEHYPDA QVSYKYTNRS PKMALNQEAY
60 70 80 90 100
NWLREQIRGL RNLHLLPEEE QWLRKNCPYL KESFYEFMHE FEFDPENSIS
110 120 130 140 150
LNYDSETKDL SIFIHGLWKN TIFYEIPLLA LVSESYFKFV DKDWSPEGQF
160 170 180 190 200
EKAYEKGKRL IRAGCAFTDF GTRRRRDPHT QEIVLQGLMK AQEDFKGPGS
210 220 230 240 250
FLGTSNVYFA AKYNLNVSGT VAHEWYMGIA AITQNYKQAN RIASLKWVQT
260 270 280 290 300
FGTSLLIALT DTFSTDVFLK SFTANSADDL ANVFHGVRQD SGCAEEYIEK
310 320 330 340 350
VVKHYKSIGV DPSTKVIVHS DALNVDRCIE LYKYCEKCGI KSAFGIGTNL
360 370 380 390 400
TSDFQKVSNP SEVSKPMNIV IKLFSAEGTK AVKISDDIMK NTGDRDAVIQ
410
AKHQLCLPIA
Length:410
Mass (Da):46,694
Last modified:May 1, 2000 - v1
Checksum:iE4230ADD9ABA6077
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB62416.1.
PIRiT50075.
RefSeqiNP_594094.1. NM_001019518.2.

Genome annotation databases

EnsemblFungiiSPAC1486.06.1; SPAC1486.06.1:pep; SPAC1486.06.
GeneIDi2542272.
KEGGispo:SPAC1486.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB62416.1 .
PIRi T50075.
RefSeqi NP_594094.1. NM_001019518.2.

3D structure databases

ProteinModelPortali Q9UTK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4710681.
STRINGi 4896.SPAC1486.06-1.

Proteomic databases

MaxQBi Q9UTK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1486.06.1 ; SPAC1486.06.1:pep ; SPAC1486.06 .
GeneIDi 2542272.
KEGGi spo:SPAC1486.06.

Organism-specific databases

PomBasei SPAC1486.06.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
InParanoidi Q9UTK3.
KOi K00763.
OMAi DWTYEGQ.
OrthoDBi EOG71K6C8.
PhylomeDBi Q9UTK3.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

NextBioi 20803336.
PROi Q9UTK3.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiNPT1_SCHPO
AccessioniPrimary (citable) accession number: Q9UTK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3