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Protein

Probable nicotinate phosphoribosyltransferase

Gene

SPAC1486.06

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate phosphoribosyltransferase (SPAC1486.06)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
ORF Names:SPAC1486.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1486.06
PomBaseiSPAC1486.06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058611 – 410Probable nicotinate phosphoribosyltransferaseAdd BLAST410

Proteomic databases

MaxQBiQ9UTK3
PaxDbiQ9UTK3
PRIDEiQ9UTK3

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC1486.06.1

Structurei

3D structure databases

ProteinModelPortaliQ9UTK3
SMRiQ9UTK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

HOGENOMiHOG000284928
InParanoidiQ9UTK3
KOiK00763
OMAiKLTMQCA
OrthoDBiEOG092C2M5Y
PhylomeDBiQ9UTK3

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UTK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPAVVSIL DTDLYKLTML QAVLEHYPDA QVSYKYTNRS PKMALNQEAY
60 70 80 90 100
NWLREQIRGL RNLHLLPEEE QWLRKNCPYL KESFYEFMHE FEFDPENSIS
110 120 130 140 150
LNYDSETKDL SIFIHGLWKN TIFYEIPLLA LVSESYFKFV DKDWSPEGQF
160 170 180 190 200
EKAYEKGKRL IRAGCAFTDF GTRRRRDPHT QEIVLQGLMK AQEDFKGPGS
210 220 230 240 250
FLGTSNVYFA AKYNLNVSGT VAHEWYMGIA AITQNYKQAN RIASLKWVQT
260 270 280 290 300
FGTSLLIALT DTFSTDVFLK SFTANSADDL ANVFHGVRQD SGCAEEYIEK
310 320 330 340 350
VVKHYKSIGV DPSTKVIVHS DALNVDRCIE LYKYCEKCGI KSAFGIGTNL
360 370 380 390 400
TSDFQKVSNP SEVSKPMNIV IKLFSAEGTK AVKISDDIMK NTGDRDAVIQ
410
AKHQLCLPIA
Length:410
Mass (Da):46,694
Last modified:May 1, 2000 - v1
Checksum:iE4230ADD9ABA6077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB62416.1
PIRiT50075
RefSeqiNP_594094.1, NM_001019518.2

Genome annotation databases

EnsemblFungiiSPAC1486.06.1; SPAC1486.06.1:pep; SPAC1486.06
KEGGispo:SPAC1486.06

Similar proteinsi

Entry informationi

Entry nameiNPT1_SCHPO
AccessioniPrimary (citable) accession number: Q9UTK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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