Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UTK3 (NPT1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
ORF Names:SPAC1486.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Probable nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_0000205861

Sequences

Sequence LengthMass (Da)Tools
Q9UTK3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E4230ADD9ABA6077

FASTA41046,694
        10         20         30         40         50         60 
MSEPAVVSIL DTDLYKLTML QAVLEHYPDA QVSYKYTNRS PKMALNQEAY NWLREQIRGL 

        70         80         90        100        110        120 
RNLHLLPEEE QWLRKNCPYL KESFYEFMHE FEFDPENSIS LNYDSETKDL SIFIHGLWKN 

       130        140        150        160        170        180 
TIFYEIPLLA LVSESYFKFV DKDWSPEGQF EKAYEKGKRL IRAGCAFTDF GTRRRRDPHT 

       190        200        210        220        230        240 
QEIVLQGLMK AQEDFKGPGS FLGTSNVYFA AKYNLNVSGT VAHEWYMGIA AITQNYKQAN 

       250        260        270        280        290        300 
RIASLKWVQT FGTSLLIALT DTFSTDVFLK SFTANSADDL ANVFHGVRQD SGCAEEYIEK 

       310        320        330        340        350        360 
VVKHYKSIGV DPSTKVIVHS DALNVDRCIE LYKYCEKCGI KSAFGIGTNL TSDFQKVSNP 

       370        380        390        400        410 
SEVSKPMNIV IKLFSAEGTK AVKISDDIMK NTGDRDAVIQ AKHQLCLPIA 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB62416.1.
PIRT50075.
RefSeqNP_594094.1. NM_001019518.2.

3D structure databases

ProteinModelPortalQ9UTK3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4710681.
STRING4896.SPAC1486.06-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1486.06.1; SPAC1486.06.1:pep; SPAC1486.06.
GeneID2542272.
KEGGspo:SPAC1486.06.

Organism-specific databases

PomBaseSPAC1486.06.

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAKLTMQCA.
OrthoDBEOG71K6C8.
PhylomeDBQ9UTK3.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Other

NextBio20803336.
PROQ9UTK3.

Entry information

Entry nameNPT1_SCHPO
AccessionPrimary (citable) accession number: Q9UTK3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways