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Protein

Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FADBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei268 – 2681FADBy similarity
Binding sitei289 – 2891SubstrateBy similarity
Binding sitei301 – 3011SubstrateBy similarity
Active sitei333 – 3331Proton acceptorBy similarity
Binding sitei400 – 4001SubstrateBy similarity
Binding sitei434 – 4341FADBy similarity
Binding sitei445 – 4451SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 666FADBy similarity
Nucleotide bindingi84 – 9916FADBy similarityAdd
BLAST
Nucleotide bindingi450 – 4512FADBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: PomBase

GO - Biological processi

  1. mitochondrial electron transport, succinate to ubiquinone Source: PomBase
  2. succinate metabolic process Source: PomBase
  3. tricarboxylic acid cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_276964. Citric acid cycle (TCA cycle).
REACT_337287. Respiratory electron transport.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:sdh1
ORF Names:SPAC1556.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1556.02c.
PomBaseiSPAC1556.02c.

Subcellular locationi

  1. Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 641Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010341
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921Tele-8alpha-FAD histidineBy similarity

Proteomic databases

MaxQBiQ9UTJ7.
PaxDbiQ9UTJ7.
PRIDEiQ9UTJ7.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

BioGridi278186. 4 interactions.
MINTiMINT-4710641.
STRINGi4896.SPAC1556.02c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTJ7.
SMRiQ9UTJ7. Positions 47-641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
InParanoidiQ9UTJ7.
KOiK00234.
OMAiKWRTCFT.
OrthoDBiEOG7V76G3.
PhylomeDBiQ9UTJ7.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UTJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFRKVAPS LKNGGNLKLF STSSTLKKIA SSQPLRAKQV STSESVKYPV
60 70 80 90 100
IDHTYDAIVV GAGGAGLRAT FGLAEAGFNT ACITKLFPTR SHTVAAQGGI
110 120 130 140 150
NAALGNMTKD DWRWHFYDTV KGSDWLGDQD AIHYMTKEAP KAVLELEHFG
160 170 180 190 200
VPFSRTKEGK IYQRAFGGQS LEYGKGGQAY RCAAVADRTG HSILHTLYGQ
210 220 230 240 250
SLKHNTNFFI EYFAMDLIME GGECRGVIAM NLEDGSIHRF RAHKTILATG
260 270 280 290 300
GYGRAYFSCT SAHTCTGDGN AMVSRAGLPL QDLEFVQFHP TGIYGAGCLI
310 320 330 340 350
TEGCRGEGGY LLNSKGERFM ERYAPTAKDL ASRDVVSRAM TVEIREGRGV
360 370 380 390 400
GPEKDHCYLQ LSHLPAEILK ERLPGISETA AIFAGVDVTK EPIPVLPTVH
410 420 430 440 450
YNMGGIPTRF TGEVLTIDEN GKDKIVPGLY AAGEAACVSV HGGNRLGANS
460 470 480 490 500
LLDIVVFGRA CALHIKDTLE PNTPHKPLAA DAGLDSLKFL DQIRTSQGPK
510 520 530 540 550
HTSEIRLDMQ KTMQRDVSVF RMEETLQEGV KNIARVDGTY KDIGIRDRGL
560 570 580 590 600
IWNTDLVEAL ELRNLLTCAV QTANAALNRK ESRGAHARED YPERDDKNWI
610 620 630 640
KHTLTWQHKT GDPVTLKYRA VTRTTMDENE VKPVPPFKRV Y
Length:641
Mass (Da):70,466
Last modified:May 1, 2000 - v1
Checksum:i5E5FCD857C372199
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141A → G in BAA13924 (PubMed:9501991).Curated
Sequence conflicti218 – 2181I → L in BAA13924 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB61213.1.
D89263 mRNA. Translation: BAA13924.1.
PIRiT50081.
RefSeqiNP_594319.1. NM_001019741.2.

Genome annotation databases

EnsemblFungiiSPAC1556.02c.1; SPAC1556.02c.1:pep; SPAC1556.02c.
GeneIDi2541690.
KEGGispo:SPAC1556.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB61213.1.
D89263 mRNA. Translation: BAA13924.1.
PIRiT50081.
RefSeqiNP_594319.1. NM_001019741.2.

3D structure databases

ProteinModelPortaliQ9UTJ7.
SMRiQ9UTJ7. Positions 47-641.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278186. 4 interactions.
MINTiMINT-4710641.
STRINGi4896.SPAC1556.02c-1.

Proteomic databases

MaxQBiQ9UTJ7.
PaxDbiQ9UTJ7.
PRIDEiQ9UTJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1556.02c.1; SPAC1556.02c.1:pep; SPAC1556.02c.
GeneIDi2541690.
KEGGispo:SPAC1556.02c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1556.02c.
PomBaseiSPAC1556.02c.

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
InParanoidiQ9UTJ7.
KOiK00234.
OMAiKWRTCFT.
OrthoDBiEOG7V76G3.
PhylomeDBiQ9UTJ7.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.
ReactomeiREACT_276964. Citric acid cycle (TCA cycle).
REACT_337287. Respiratory electron transport.

Miscellaneous databases

NextBioi20802783.
PROiQ9UTJ7.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-641.
    Strain: PR745.

Entry informationi

Entry nameiSDHA_SCHPO
AccessioniPrimary (citable) accession number: Q9UTJ7
Secondary accession number(s): P78912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.