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Q9UTJ7

- SDHA_SCHPO

UniProt

Q9UTJ7 - SDHA_SCHPO

Protein

Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei268 – 2681FADBy similarity
    Binding sitei289 – 2891SubstrateBy similarity
    Binding sitei301 – 3011SubstrateBy similarity
    Active sitei333 – 3331Proton acceptorBy similarity
    Binding sitei400 – 4001SubstrateBy similarity
    Binding sitei434 – 4341FADBy similarity
    Binding sitei445 – 4451SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 666FADBy similarity
    Nucleotide bindingi84 – 9916FADBy similarityAdd
    BLAST
    Nucleotide bindingi450 – 4512FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: PomBase

    GO - Biological processi

    1. mitochondrial electron transport, succinate to ubiquinone Source: PomBase
    2. succinate metabolic process Source: PomBase
    3. tricarboxylic acid cycle Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    ReactomeiREACT_213505. Citric acid cycle (TCA cycle).
    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex II
    Short name:
    FP
    Gene namesi
    Name:sdh1
    ORF Names:SPAC1556.02c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1556.02c.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex II Source: PomBase
    2. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 641Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010341
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei92 – 921Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    MaxQBiQ9UTJ7.
    PaxDbiQ9UTJ7.
    PRIDEiQ9UTJ7.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

    Protein-protein interaction databases

    BioGridi278186. 4 interactions.
    MINTiMINT-4710641.
    STRINGi4896.SPAC1556.02c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UTJ7.
    SMRiQ9UTJ7. Positions 47-641.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1053.
    HOGENOMiHOG000160475.
    KOiK00234.
    OMAiRDGPILQ.
    OrthoDBiEOG7V76G3.
    PhylomeDBiQ9UTJ7.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UTJ7-1 [UniParc]FASTAAdd to Basket

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    MLRFRKVAPS LKNGGNLKLF STSSTLKKIA SSQPLRAKQV STSESVKYPV    50
    IDHTYDAIVV GAGGAGLRAT FGLAEAGFNT ACITKLFPTR SHTVAAQGGI 100
    NAALGNMTKD DWRWHFYDTV KGSDWLGDQD AIHYMTKEAP KAVLELEHFG 150
    VPFSRTKEGK IYQRAFGGQS LEYGKGGQAY RCAAVADRTG HSILHTLYGQ 200
    SLKHNTNFFI EYFAMDLIME GGECRGVIAM NLEDGSIHRF RAHKTILATG 250
    GYGRAYFSCT SAHTCTGDGN AMVSRAGLPL QDLEFVQFHP TGIYGAGCLI 300
    TEGCRGEGGY LLNSKGERFM ERYAPTAKDL ASRDVVSRAM TVEIREGRGV 350
    GPEKDHCYLQ LSHLPAEILK ERLPGISETA AIFAGVDVTK EPIPVLPTVH 400
    YNMGGIPTRF TGEVLTIDEN GKDKIVPGLY AAGEAACVSV HGGNRLGANS 450
    LLDIVVFGRA CALHIKDTLE PNTPHKPLAA DAGLDSLKFL DQIRTSQGPK 500
    HTSEIRLDMQ KTMQRDVSVF RMEETLQEGV KNIARVDGTY KDIGIRDRGL 550
    IWNTDLVEAL ELRNLLTCAV QTANAALNRK ESRGAHARED YPERDDKNWI 600
    KHTLTWQHKT GDPVTLKYRA VTRTTMDENE VKPVPPFKRV Y 641
    Length:641
    Mass (Da):70,466
    Last modified:May 1, 2000 - v1
    Checksum:i5E5FCD857C372199
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti214 – 2141A → G in BAA13924. (PubMed:9501991)Curated
    Sequence conflicti218 – 2181I → L in BAA13924. (PubMed:9501991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB61213.1.
    D89263 mRNA. Translation: BAA13924.1.
    PIRiT50081.
    RefSeqiNP_594319.1. NM_001019741.2.

    Genome annotation databases

    EnsemblFungiiSPAC1556.02c.1; SPAC1556.02c.1:pep; SPAC1556.02c.
    GeneIDi2541690.
    KEGGispo:SPAC1556.02c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB61213.1 .
    D89263 mRNA. Translation: BAA13924.1 .
    PIRi T50081.
    RefSeqi NP_594319.1. NM_001019741.2.

    3D structure databases

    ProteinModelPortali Q9UTJ7.
    SMRi Q9UTJ7. Positions 47-641.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278186. 4 interactions.
    MINTi MINT-4710641.
    STRINGi 4896.SPAC1556.02c-1.

    Proteomic databases

    MaxQBi Q9UTJ7.
    PaxDbi Q9UTJ7.
    PRIDEi Q9UTJ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1556.02c.1 ; SPAC1556.02c.1:pep ; SPAC1556.02c .
    GeneIDi 2541690.
    KEGGi spo:SPAC1556.02c.

    Organism-specific databases

    PomBasei SPAC1556.02c.

    Phylogenomic databases

    eggNOGi COG1053.
    HOGENOMi HOG000160475.
    KOi K00234.
    OMAi RDGPILQ.
    OrthoDBi EOG7V76G3.
    PhylomeDBi Q9UTJ7.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .
    Reactomei REACT_213505. Citric acid cycle (TCA cycle).

    Miscellaneous databases

    NextBioi 20802783.
    PROi Q9UTJ7.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-641.
      Strain: PR745.

    Entry informationi

    Entry nameiSDHA_SCHPO
    AccessioniPrimary (citable) accession number: Q9UTJ7
    Secondary accession number(s): P78912
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3