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Q9UTJ2

- PMM_SCHPO

UniProt

Q9UTJ2 - PMM_SCHPO

Protein

Phosphomannomutase

Gene

pmm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei19 – 191NucleophileBy similarity
    Active sitei21 – 211Proton donor/acceptorSequence Analysis
    Binding sitei28 – 281SubstrateBy similarity
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei144 – 1441SubstrateBy similarity
    Binding sitei151 – 1511SubstrateBy similarity
    Binding sitei189 – 1891SubstrateBy similarity
    Binding sitei191 – 1911SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: PomBase

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: PomBase
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    3. intracellular protein transport Source: PomBase
    4. mannose biosynthetic process Source: InterPro
    5. nuclear envelope organization Source: PomBase
    6. protein targeting to ER Source: PomBase

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    ReactomeiREACT_188590. Synthesis of GDP-mannose.
    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:pmm1
    ORF Names:SPAC1556.07
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1556.07.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257PhosphomannomutasePRO_0000199702Add
    BLAST

    Proteomic databases

    MaxQBiQ9UTJ2.
    PaxDbiQ9UTJ2.
    PRIDEiQ9UTJ2.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi278170. 6 interactions.
    MINTiMINT-4710595.
    STRINGi4896.SPAC1556.07-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UTJ2.
    SMRiQ9UTJ2. Positions 13-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Phylogenomic databases

    eggNOGiCOG0561.
    HOGENOMiHOG000181843.
    KOiK17497.
    OMAiTYCLQHV.
    OrthoDBiEOG7X3R31.
    PhylomeDBiQ9UTJ2.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UTJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVIPIEERK FPKTLVLFDV DGTLTPARLS VSPEMLETLQ NLRKVVAIGF    50
    VGGSDLSKQQ EQLSVNGENV IDSFDYAFAE NGLTAYRYGQ QLASQSFIAW 100
    LGEEKYQKLV NFCLHYIADL DIPVKRGTFI EFRNGMINIS PVGRNANTEE 150
    RNEFERFDKG RKIRATMVDV LREKFKDYGL TFSIGGQISF DVFPAGWDKT 200
    YCLQHVEKEG FDTIHFFGDK TYKGGNDYEI FVDPRTIGHS VTNPDDTIAE 250
    LKKIFNI 257
    Length:257
    Mass (Da):29,223
    Last modified:May 1, 2000 - v1
    Checksum:i789AA77A7C169E52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB61218.1.
    AB000703 mRNA. Translation: BAA19164.1.
    PIRiT50086.
    RefSeqiNP_594325.1. NM_001019747.2.

    Genome annotation databases

    EnsemblFungiiSPAC1556.07.1; SPAC1556.07.1:pep; SPAC1556.07.
    GeneIDi2541674.
    KEGGispo:SPAC1556.07.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB61218.1 .
    AB000703 mRNA. Translation: BAA19164.1 .
    PIRi T50086.
    RefSeqi NP_594325.1. NM_001019747.2.

    3D structure databases

    ProteinModelPortali Q9UTJ2.
    SMRi Q9UTJ2. Positions 13-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278170. 6 interactions.
    MINTi MINT-4710595.
    STRINGi 4896.SPAC1556.07-1.

    Proteomic databases

    MaxQBi Q9UTJ2.
    PaxDbi Q9UTJ2.
    PRIDEi Q9UTJ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1556.07.1 ; SPAC1556.07.1:pep ; SPAC1556.07 .
    GeneIDi 2541674.
    KEGGi spo:SPAC1556.07.

    Organism-specific databases

    PomBasei SPAC1556.07.

    Phylogenomic databases

    eggNOGi COG0561.
    HOGENOMi HOG000181843.
    KOi K17497.
    OMAi TYCLQHV.
    OrthoDBi EOG7X3R31.
    PhylomeDBi Q9UTJ2.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    Reactomei REACT_188590. Synthesis of GDP-mannose.

    Miscellaneous databases

    NextBioi 20802767.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "S.pombe phosphomannomutase homolog."
      Kawamukai M.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-257.

    Entry informationi

    Entry nameiPMM_SCHPO
    AccessioniPrimary (citable) accession number: Q9UTJ2
    Secondary accession number(s): P79012
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3