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Protein

Phosphomannomutase

Gene

pmm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (pmi40)
  2. Phosphomannomutase (pmm1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19NucleophileBy similarity1
Active sitei21Proton donor/acceptorSequence analysis1
Binding sitei28SubstrateBy similarity1
Binding sitei133SubstrateBy similarity1
Binding sitei144SubstrateBy similarity1
Binding sitei151SubstrateBy similarity1
Binding sitei189SubstrateBy similarity1
Binding sitei191SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-SPO-446205 Synthesis of GDP-mannose
UniPathwayiUPA00126; UER00424

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:pmm1
ORF Names:SPAC1556.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1556.07
PomBaseiSPAC1556.07 pmm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997021 – 257PhosphomannomutaseAdd BLAST257

Proteomic databases

MaxQBiQ9UTJ2
PaxDbiQ9UTJ2
PRIDEiQ9UTJ2

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi278170, 5 interactors
STRINGi4896.SPAC1556.07.1

Structurei

3D structure databases

ProteinModelPortaliQ9UTJ2
SMRiQ9UTJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

HOGENOMiHOG000181843
InParanoidiQ9UTJ2
KOiK17497
OMAiTYCLQHL
OrthoDBiEOG092C4IV8
PhylomeDBiQ9UTJ2

Family and domain databases

CDDicd02585 HAD_PMM, 1 hit
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006379 HAD-SF_hydro_IIB
IPR023214 HAD_sf
IPR005002 PMM
PANTHERiPTHR10466 PTHR10466, 1 hit
PfamiView protein in Pfam
PF03332 PMM, 1 hit
SFLDiSFLDG01143 C2.B.3:_Phosphomannomutase_Lik, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01484 HAD-SF-IIB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UTJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVIPIEERK FPKTLVLFDV DGTLTPARLS VSPEMLETLQ NLRKVVAIGF
60 70 80 90 100
VGGSDLSKQQ EQLSVNGENV IDSFDYAFAE NGLTAYRYGQ QLASQSFIAW
110 120 130 140 150
LGEEKYQKLV NFCLHYIADL DIPVKRGTFI EFRNGMINIS PVGRNANTEE
160 170 180 190 200
RNEFERFDKG RKIRATMVDV LREKFKDYGL TFSIGGQISF DVFPAGWDKT
210 220 230 240 250
YCLQHVEKEG FDTIHFFGDK TYKGGNDYEI FVDPRTIGHS VTNPDDTIAE

LKKIFNI
Length:257
Mass (Da):29,223
Last modified:May 1, 2000 - v1
Checksum:i789AA77A7C169E52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB61218.1
AB000703 mRNA Translation: BAA19164.1
PIRiT50086
RefSeqiNP_594325.1, NM_001019747.2

Genome annotation databases

EnsemblFungiiSPAC1556.07.1; SPAC1556.07.1:pep; SPAC1556.07
GeneIDi2541674
KEGGispo:SPAC1556.07

Similar proteinsi

Entry informationi

Entry nameiPMM_SCHPO
AccessioniPrimary (citable) accession number: Q9UTJ2
Secondary accession number(s): P79012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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