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Q9UTJ2

- PMM_SCHPO

UniProt

Q9UTJ2 - PMM_SCHPO

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Protein

Phosphomannomutase

Gene

pmm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei19 – 191NucleophileBy similarity
Active sitei21 – 211Proton donor/acceptorSequence Analysis
Binding sitei28 – 281SubstrateBy similarity
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei144 – 1441SubstrateBy similarity
Binding sitei151 – 1511SubstrateBy similarity
Binding sitei189 – 1891SubstrateBy similarity
Binding sitei191 – 1911SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: PomBase

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: PomBase
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  3. intracellular protein transport Source: PomBase
  4. mannose biosynthetic process Source: InterPro
  5. nuclear envelope organization Source: PomBase
  6. protein targeting to ER Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_188590. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:pmm1
ORF Names:SPAC1556.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1556.07.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257PhosphomannomutasePRO_0000199702Add
BLAST

Proteomic databases

MaxQBiQ9UTJ2.
PaxDbiQ9UTJ2.
PRIDEiQ9UTJ2.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi278170. 6 interactions.
MINTiMINT-4710595.
STRINGi4896.SPAC1556.07-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTJ2.
SMRiQ9UTJ2. Positions 13-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
HOGENOMiHOG000181843.
InParanoidiQ9UTJ2.
KOiK17497.
OMAiTYCLQHV.
OrthoDBiEOG7X3R31.
PhylomeDBiQ9UTJ2.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVIPIEERK FPKTLVLFDV DGTLTPARLS VSPEMLETLQ NLRKVVAIGF
60 70 80 90 100
VGGSDLSKQQ EQLSVNGENV IDSFDYAFAE NGLTAYRYGQ QLASQSFIAW
110 120 130 140 150
LGEEKYQKLV NFCLHYIADL DIPVKRGTFI EFRNGMINIS PVGRNANTEE
160 170 180 190 200
RNEFERFDKG RKIRATMVDV LREKFKDYGL TFSIGGQISF DVFPAGWDKT
210 220 230 240 250
YCLQHVEKEG FDTIHFFGDK TYKGGNDYEI FVDPRTIGHS VTNPDDTIAE

LKKIFNI
Length:257
Mass (Da):29,223
Last modified:May 1, 2000 - v1
Checksum:i789AA77A7C169E52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB61218.1.
AB000703 mRNA. Translation: BAA19164.1.
PIRiT50086.
RefSeqiNP_594325.1. NM_001019747.2.

Genome annotation databases

EnsemblFungiiSPAC1556.07.1; SPAC1556.07.1:pep; SPAC1556.07.
GeneIDi2541674.
KEGGispo:SPAC1556.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB61218.1 .
AB000703 mRNA. Translation: BAA19164.1 .
PIRi T50086.
RefSeqi NP_594325.1. NM_001019747.2.

3D structure databases

ProteinModelPortali Q9UTJ2.
SMRi Q9UTJ2. Positions 13-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278170. 6 interactions.
MINTi MINT-4710595.
STRINGi 4896.SPAC1556.07-1.

Proteomic databases

MaxQBi Q9UTJ2.
PaxDbi Q9UTJ2.
PRIDEi Q9UTJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1556.07.1 ; SPAC1556.07.1:pep ; SPAC1556.07 .
GeneIDi 2541674.
KEGGi spo:SPAC1556.07.

Organism-specific databases

PomBasei SPAC1556.07.

Phylogenomic databases

eggNOGi COG0561.
HOGENOMi HOG000181843.
InParanoidi Q9UTJ2.
KOi K17497.
OMAi TYCLQHV.
OrthoDBi EOG7X3R31.
PhylomeDBi Q9UTJ2.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .
Reactomei REACT_188590. Synthesis of GDP-mannose.

Miscellaneous databases

NextBioi 20802767.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "S.pombe phosphomannomutase homolog."
    Kawamukai M.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-257.

Entry informationi

Entry nameiPMM_SCHPO
AccessioniPrimary (citable) accession number: Q9UTJ2
Secondary accession number(s): P79012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3