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Protein

Probable ethanolamine-phosphate cytidylyltransferase

Gene

SPAC15E1.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable ethanolamine-phosphate cytidylyltransferase (SPAC15E1.05c)
  3. no protein annotated in this organism
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-SPO-1483213. Synthesis of PE.
UniPathwayiUPA00558; UER00742.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ethanolamine-phosphate cytidylyltransferase (EC:2.7.7.14)
Alternative name(s):
CTP:phosphoethanolamine cytidylyltransferase
Phosphorylethanolamine transferase
Gene namesi
ORF Names:SPAC15E1.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC15E1.05c.
PomBaseiSPAC15E1.05c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Probable ethanolamine-phosphate cytidylyltransferasePRO_0000208464Add
BLAST

Proteomic databases

MaxQBiQ9UTI6.

Interactioni

Protein-protein interaction databases

BioGridi279224. 2 interactions.
MINTiMINT-4710561.

Structurei

3D structure databases

ProteinModelPortaliQ9UTI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylyltransferase family.Curated

Phylogenomic databases

HOGENOMiHOG000187618.
InParanoidiQ9UTI6.
KOiK00967.
OMAiMASHEIQ.
OrthoDBiEOG092C3LI1.
PhylomeDBiQ9UTI6.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR004821. Cyt_trans-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSNIKHR LWLDGCMDFF HYGHSNAILQ AKQLGETLVI GIHSDEEITL
60 70 80 90 100
NKGPPVMTLE ERCLSANTCK WVDEVVPSAP YVFDLEWMRR YGCQYVVHGD
110 120 130 140 150
DISTDANGDD CYRFAKAADQ YLEVKRTEGV STTELLDRLL SSVPLEIYST
160 170 180 190 200
PVSVLSSQID LLRRFATDSD GLTPFTDVFI YNTEKPETLI SGTTLLRLNP
210 220 230 240 250
EKNIIYIDGD WDLFTEKHIS ALELCTRMFP GIPIMAGIFA DEKCFEKPML
260 270 280 290 300
NLLERILNLL QCKYISSILV GPPPASLFAS SKYIKLCFDE QISKVYYPIF
310 320 330 340 350
STDVSIPALD ISLSNTPNNS FYKFDKLGSD LIKQRVMLRR QHYEERQRRK
360
MGKNATEQTT IKTYA
Length:365
Mass (Da):41,557
Last modified:May 1, 2000 - v1
Checksum:iACDB6A974ABB4734
GO

Sequence cautioni

The sequence BAA13860 differs from that shown. Reason: Frameshift at position 47. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631C → G in BAA13860 (PubMed:9501991).Curated
Sequence conflicti268 – 2681I → L in BAA13860 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52424.1.
D89199 mRNA. Translation: BAA13860.1. Frameshift.
PIRiT37720.
T42999.
RefSeqiNP_594306.1. NM_001019729.2.

Genome annotation databases

EnsemblFungiiSPAC15E1.05c.1; SPAC15E1.05c.1:pep; SPAC15E1.05c.
GeneIDi2542775.
KEGGispo:SPAC15E1.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52424.1.
D89199 mRNA. Translation: BAA13860.1. Frameshift.
PIRiT37720.
T42999.
RefSeqiNP_594306.1. NM_001019729.2.

3D structure databases

ProteinModelPortaliQ9UTI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279224. 2 interactions.
MINTiMINT-4710561.

Proteomic databases

MaxQBiQ9UTI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC15E1.05c.1; SPAC15E1.05c.1:pep; SPAC15E1.05c.
GeneIDi2542775.
KEGGispo:SPAC15E1.05c.

Organism-specific databases

EuPathDBiFungiDB:SPAC15E1.05c.
PomBaseiSPAC15E1.05c.

Phylogenomic databases

HOGENOMiHOG000187618.
InParanoidiQ9UTI6.
KOiK00967.
OMAiMASHEIQ.
OrthoDBiEOG092C3LI1.
PhylomeDBiQ9UTI6.

Enzyme and pathway databases

UniPathwayiUPA00558; UER00742.
ReactomeiR-SPO-1483213. Synthesis of PE.

Miscellaneous databases

PROiQ9UTI6.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR004821. Cyt_trans-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiECT1_SCHPO
AccessioniPrimary (citable) accession number: Q9UTI6
Secondary accession number(s): P78849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.