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Q9UTH5

- PLB6_SCHPO

UniProt

Q9UTH5 - PLB6_SCHPO

Protein

Probable lysophospholipase C1786.02

Gene

SPAC1786.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the release of fatty acids from lysophospholipids.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC
    2. phospholipase activity Source: PomBase

    GO - Biological processi

    1. glycerophospholipid catabolic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable lysophospholipase C1786.02 (EC:3.1.1.5)
    Alternative name(s):
    Phospholipase B
    Gene namesi
    ORF Names:SPAC1786.02
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1786.02.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: PomBase
    2. endoplasmic reticulum Source: PomBase
    3. extracellular region Source: UniProtKB-SubCell
    4. fungal-type cell wall Source: PomBase

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 644625Probable lysophospholipase C1786.02PRO_0000024644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9UTH5.
    PaxDbiQ9UTH5.

    Interactioni

    Protein-protein interaction databases

    BioGridi278640. 3 interactions.
    MINTiMINT-4710476.
    STRINGi4896.SPAC1786.02-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UTH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 600548PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysophospholipase family.Curated
    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG290086.
    HOGENOMiHOG000189547.
    KOiK13333.
    OMAiVHANILL.
    OrthoDBiEOG7N37NC.
    PhylomeDBiQ9UTH5.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UTH5-1 [UniParc]FASTAAdd to Basket

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    MYFQSFYFLA LLLATAVYGQ VASPELHSLS RRNWKKPPPF PSTNASYAPV    50
    IRSCDSSEIM VNSLPRGELP DLENDFIEKR LSNANEALTT FLQSKNTTAD 100
    LDLSSIVGDN GPRLGIAVSG GGWRSMLFGG GALAALDSRS NETTLGGLLQ 150
    SAHYITGADG GSWLLSSLAV NEFRTIQNIS KSIWYTRLGI FFIEETHFGD 200
    LKNYYTNVVD EVNQKAAAGF NVSLTDYWGR AIARHFVGQL RGGPNLTYSS 250
    VQNASWFQTA EYPYPLIVTQ GLTGGLPDGS NGTATNSSIY EISPYYLTSF 300
    DNNVRSYTPT QYLGTNYSNG TAVDGKCVTQ FDNVGFLVGT SSTRYNEALI 350
    DVSLRQSRMS RRLGFTLRHM RINGSSVSFY PNPYTDATDI AGNATAVSED 400
    IVDTPYLDLF DGGYDGQNIP IWPLLQPERK LDVVFAFDSS GDTSNFWPNG 450
    SSLVATYERV TQRASDAVYD VEDFVHVPTP ETFVNLGLNA NPTFFGCDGR 500
    NTTRGDVPVD HNTPPLVVYM PNTPWTMKSN LVDHRYRIAN SEIQALIQNG 550
    FVATTQDNST DFASCLACAV VQRSLERRNQ STSAACQQCF SQYCWNGTVD 600
    NTPVDDDSKN PTYNPAVKTS SASGVHANIL LSFFVLLATL LVTA 644
    Length:644
    Mass (Da):70,570
    Last modified:May 1, 2000 - v1
    Checksum:iEB42D2427EA804D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB57433.1.
    AB027917 Genomic DNA. Translation: BAA87221.1.
    PIRiT37800.
    RefSeqiNP_594024.1. NM_001019449.2.

    Genome annotation databases

    EnsemblFungiiSPAC1786.02.1; SPAC1786.02.1:pep; SPAC1786.02.
    GeneIDi2542164.
    KEGGispo:SPAC1786.02.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB57433.1 .
    AB027917 Genomic DNA. Translation: BAA87221.1 .
    PIRi T37800.
    RefSeqi NP_594024.1. NM_001019449.2.

    3D structure databases

    ProteinModelPortali Q9UTH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278640. 3 interactions.
    MINTi MINT-4710476.
    STRINGi 4896.SPAC1786.02-1.

    Proteomic databases

    MaxQBi Q9UTH5.
    PaxDbi Q9UTH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1786.02.1 ; SPAC1786.02.1:pep ; SPAC1786.02 .
    GeneIDi 2542164.
    KEGGi spo:SPAC1786.02.

    Organism-specific databases

    PomBasei SPAC1786.02.

    Phylogenomic databases

    eggNOGi NOG290086.
    HOGENOMi HOG000189547.
    KOi K13333.
    OMAi VHANILL.
    OrthoDBi EOG7N37NC.
    PhylomeDBi Q9UTH5.

    Miscellaneous databases

    NextBioi 20803236.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-102.
      Strain: ATCC 38364 / 968.

    Entry informationi

    Entry nameiPLB6_SCHPO
    AccessioniPrimary (citable) accession number: Q9UTH5
    Secondary accession number(s): Q9UTZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3