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Q9UTH5

- PLB6_SCHPO

UniProt

Q9UTH5 - PLB6_SCHPO

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Protein

Probable lysophospholipase C1786.02

Gene

SPAC1786.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
  2. phospholipase activity Source: PomBase

GO - Biological processi

  1. glycerophospholipid catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysophospholipase C1786.02 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
Gene namesi
ORF Names:SPAC1786.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1786.02.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: PomBase
  2. endoplasmic reticulum Source: PomBase
  3. extracellular region Source: UniProtKB-KW
  4. fungal-type cell wall Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 644625Probable lysophospholipase C1786.02PRO_0000024644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UTH5.
PaxDbiQ9UTH5.

Interactioni

Protein-protein interaction databases

BioGridi278640. 3 interactions.
MINTiMINT-4710476.
STRINGi4896.SPAC1786.02-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 600548PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG290086.
HOGENOMiHOG000189547.
InParanoidiQ9UTH5.
KOiK13333.
OMAiVHANILL.
OrthoDBiEOG7N37NC.
PhylomeDBiQ9UTH5.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UTH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYFQSFYFLA LLLATAVYGQ VASPELHSLS RRNWKKPPPF PSTNASYAPV
60 70 80 90 100
IRSCDSSEIM VNSLPRGELP DLENDFIEKR LSNANEALTT FLQSKNTTAD
110 120 130 140 150
LDLSSIVGDN GPRLGIAVSG GGWRSMLFGG GALAALDSRS NETTLGGLLQ
160 170 180 190 200
SAHYITGADG GSWLLSSLAV NEFRTIQNIS KSIWYTRLGI FFIEETHFGD
210 220 230 240 250
LKNYYTNVVD EVNQKAAAGF NVSLTDYWGR AIARHFVGQL RGGPNLTYSS
260 270 280 290 300
VQNASWFQTA EYPYPLIVTQ GLTGGLPDGS NGTATNSSIY EISPYYLTSF
310 320 330 340 350
DNNVRSYTPT QYLGTNYSNG TAVDGKCVTQ FDNVGFLVGT SSTRYNEALI
360 370 380 390 400
DVSLRQSRMS RRLGFTLRHM RINGSSVSFY PNPYTDATDI AGNATAVSED
410 420 430 440 450
IVDTPYLDLF DGGYDGQNIP IWPLLQPERK LDVVFAFDSS GDTSNFWPNG
460 470 480 490 500
SSLVATYERV TQRASDAVYD VEDFVHVPTP ETFVNLGLNA NPTFFGCDGR
510 520 530 540 550
NTTRGDVPVD HNTPPLVVYM PNTPWTMKSN LVDHRYRIAN SEIQALIQNG
560 570 580 590 600
FVATTQDNST DFASCLACAV VQRSLERRNQ STSAACQQCF SQYCWNGTVD
610 620 630 640
NTPVDDDSKN PTYNPAVKTS SASGVHANIL LSFFVLLATL LVTA
Length:644
Mass (Da):70,570
Last modified:May 1, 2000 - v1
Checksum:iEB42D2427EA804D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB57433.1.
AB027917 Genomic DNA. Translation: BAA87221.1.
PIRiT37800.
RefSeqiNP_594024.1. NM_001019449.2.

Genome annotation databases

EnsemblFungiiSPAC1786.02.1; SPAC1786.02.1:pep; SPAC1786.02.
GeneIDi2542164.
KEGGispo:SPAC1786.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB57433.1 .
AB027917 Genomic DNA. Translation: BAA87221.1 .
PIRi T37800.
RefSeqi NP_594024.1. NM_001019449.2.

3D structure databases

ProteinModelPortali Q9UTH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278640. 3 interactions.
MINTi MINT-4710476.
STRINGi 4896.SPAC1786.02-1.

Proteomic databases

MaxQBi Q9UTH5.
PaxDbi Q9UTH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1786.02.1 ; SPAC1786.02.1:pep ; SPAC1786.02 .
GeneIDi 2542164.
KEGGi spo:SPAC1786.02.

Organism-specific databases

PomBasei SPAC1786.02.

Phylogenomic databases

eggNOGi NOG290086.
HOGENOMi HOG000189547.
InParanoidi Q9UTH5.
KOi K13333.
OMAi VHANILL.
OrthoDBi EOG7N37NC.
PhylomeDBi Q9UTH5.

Miscellaneous databases

NextBioi 20803236.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-102.
    Strain: ATCC 38364 / 968.

Entry informationi

Entry nameiPLB6_SCHPO
AccessioniPrimary (citable) accession number: Q9UTH5
Secondary accession number(s): Q9UTZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3