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Protein

tRNA:m(4)X modification enzyme TRM13

Gene

trm13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

tRNA methylase which 2'-O-methylates cytidine4 in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine4 in tRNA(His).By similarity

Catalytic activityi

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.
S-adenosyl-L-methionine + cytidine4 in tRNA(Pro) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Pro).
S-adenosyl-L-methionine + cytidine4 in tRNA(Gly)(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Gly)(GCC).
S-adenosyl-L-methionine + adenosine4 in tRNA(His) = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNA(His).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 4228CHHC U11-48K-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA:m(4)X modification enzyme TRM13 (EC:2.1.1.225)
Alternative name(s):
tRNA methylase 13
Gene namesi
Name:trm13
ORF Names:SPAC1805.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1805.03c.
PomBaseiSPAC1805.03c. trm13.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368tRNA:m(4)X modification enzyme TRM13PRO_0000339427Add
BLAST

Proteomic databases

MaxQBiQ9UTH1.

Interactioni

Protein-protein interaction databases

BioGridi278862. 41 interactions.
MINTiMINT-4710440.

Family & Domainsi

Sequence similaritiesi

Belongs to the TRM13 family.Curated
Contains 1 CHHC U11-48K-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 4228CHHC U11-48K-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ9UTH1.
KOiK15446.
OMAiATCGMRE.
OrthoDBiEOG092C2SYB.

Family and domain databases

InterProiIPR007871. Methyltransferase_TRM13.
IPR022776. TRM13/UPF0224_CHHC_Znf_dom.
[Graphical view]
PfamiPF05206. TRM13. 1 hit.
PF05253. zf-U11-48K. 1 hit.
[Graphical view]
PROSITEiPS51800. ZF_CHHC_U11_48K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UTH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIKKIFTQ EELKQIPCPY DHKHTIVRHR LEYHLKRCNA RPVERTDPYY
60 70 80 90 100
KKDINISTST DASESSSFEI VDLSKEELSK WICLFNRISD SLPTPQKKVL
110 120 130 140 150
FHPAMNARLE EGTKKKHAIQ QASLLGHMEK LHYFDNQGSI YYEFGAGRAE
160 170 180 190 200
LSRYVQHCSQ QENVYILIDR DSNRTKHDSR ILKDSIKNNW PEPKIIRCKI
210 220 230 240 250
DIKDLKLDFF ASEFRNSGKP VFAYSKHLCG AATDLTLNCL KSSPPNALVI
260 270 280 290 300
ALCCHHHCRW RTLSTFAREQ LSHWGISNPQ EFQILRQMTG WAVNSLREHM
310 320 330 340 350
HASGGADSHI SGLSHEERVK IGLKCKHIIN YMRKLECEKM GYESSLVYYV
360
GEETTLENVA LIAYKRIN
Length:368
Mass (Da):42,666
Last modified:June 13, 2012 - v2
Checksum:i6440DAEE8FA9B4E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB55844.2.
PIRiT37888.
RefSeqiNP_593914.2. NM_001019343.2.

Genome annotation databases

EnsemblFungiiSPAC1805.03c.1; SPAC1805.03c.1:pep; SPAC1805.03c.
GeneIDi2542398.
KEGGispo:SPAC1805.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB55844.2.
PIRiT37888.
RefSeqiNP_593914.2. NM_001019343.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278862. 41 interactions.
MINTiMINT-4710440.

Proteomic databases

MaxQBiQ9UTH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1805.03c.1; SPAC1805.03c.1:pep; SPAC1805.03c.
GeneIDi2542398.
KEGGispo:SPAC1805.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1805.03c.
PomBaseiSPAC1805.03c. trm13.

Phylogenomic databases

InParanoidiQ9UTH1.
KOiK15446.
OMAiATCGMRE.
OrthoDBiEOG092C2SYB.

Miscellaneous databases

PROiQ9UTH1.

Family and domain databases

InterProiIPR007871. Methyltransferase_TRM13.
IPR022776. TRM13/UPF0224_CHHC_Znf_dom.
[Graphical view]
PfamiPF05206. TRM13. 1 hit.
PF05253. zf-U11-48K. 1 hit.
[Graphical view]
PROSITEiPS51800. ZF_CHHC_U11_48K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM13_SCHPO
AccessioniPrimary (citable) accession number: Q9UTH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 13, 2012
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.