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Protein

Putative purine nucleoside phosphorylase

Gene

SPAC1805.16c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).By similarity

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49PhosphateBy similarity1
Binding sitei81PhosphateBy similarity1
Binding sitei135Phosphate; via amide nitrogenBy similarity1
Binding sitei220Purine nucleosideBy similarity1
Binding sitei239PhosphateBy similarity1
Binding sitei262Purine nucleosideBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-74217. Purine salvage.
R-SPO-74259. Purine catabolism.
UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative purine nucleoside phosphorylase (EC:2.4.2.1)
Short name:
PNP
Alternative name(s):
Inosine phosphorylase
Inosine-guanosine phosphorylase
Gene namesi
ORF Names:SPAC1805.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1805.16c.
PomBaseiSPAC1805.16c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003162211 – 315Putative purine nucleoside phosphorylaseAdd BLAST315

Proteomic databases

MaxQBiQ9UTG1.
PRIDEiQ9UTG1.

Interactioni

Protein-protein interaction databases

BioGridi278897. 11 interactors.
MINTiMINT-4710355.

Structurei

3D structure databases

ProteinModelPortaliQ9UTG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 105Phosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.Curated

Phylogenomic databases

HOGENOMiHOG000045183.
InParanoidiQ9UTG1.
KOiK03783.
OMAiMENGYTY.
OrthoDBiEOG092C4NS7.
PhylomeDBiQ9UTG1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 2 hits.
PTHR11904:SF9. PTHR11904:SF9. 2 hits.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATSFLHQA KQQPHHTEPY IKALEAREYI IEQVPEELSK PKVAIICGSG
60 70 80 90 100
LGTLASGLSA PVYEVPYEDI PHFHVSHVPG HASKLYFAFL GEKRVPTMIL
110 120 130 140 150
AGRYHSYEGY PIEATTFPVR LMKVMGVEVM VVTNAAGGLN QGFKVGDLMI
160 170 180 190 200
LKDHINFPGL AGMNPLRGPN AHEFGVRFPP LSDAYDLELR KLVYDAAKAH
210 220 230 240 250
KVSRTIHEGC YAFVSGPCFE TRAESRMLAL MGADCVGMST VPEVVVARHC
260 270 280 290 300
GIRVLAISLV TNNVVVEESP SAKDLVEVDS NVMSKGAANH LEVLEVGIAA
310
AADVRTMVET IVNFI
Length:315
Mass (Da):34,239
Last modified:May 1, 2000 - v1
Checksum:i9B7DC695C71D7BC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB55857.1.
PIRiT37901.
RefSeqiNP_593927.1. NM_001019356.2.

Genome annotation databases

EnsemblFungiiSPAC1805.16c.1; SPAC1805.16c.1:pep; SPAC1805.16c.
GeneIDi2542435.
KEGGispo:SPAC1805.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB55857.1.
PIRiT37901.
RefSeqiNP_593927.1. NM_001019356.2.

3D structure databases

ProteinModelPortaliQ9UTG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278897. 11 interactors.
MINTiMINT-4710355.

Proteomic databases

MaxQBiQ9UTG1.
PRIDEiQ9UTG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1805.16c.1; SPAC1805.16c.1:pep; SPAC1805.16c.
GeneIDi2542435.
KEGGispo:SPAC1805.16c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1805.16c.
PomBaseiSPAC1805.16c.

Phylogenomic databases

HOGENOMiHOG000045183.
InParanoidiQ9UTG1.
KOiK03783.
OMAiMENGYTY.
OrthoDBiEOG092C4NS7.
PhylomeDBiQ9UTG1.

Enzyme and pathway databases

UniPathwayiUPA00606.
ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-74217. Purine salvage.
R-SPO-74259. Purine catabolism.

Miscellaneous databases

PROiQ9UTG1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 2 hits.
PTHR11904:SF9. PTHR11904:SF9. 2 hits.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPNPH_SCHPO
AccessioniPrimary (citable) accession number: Q9UTG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.