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Q9UTG1

- PNPH_SCHPO

UniProt

Q9UTG1 - PNPH_SCHPO

Protein

Putative purine nucleoside phosphorylase

Gene

SPAC1805.16c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine By similarity.By similarity

    Catalytic activityi

    Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. purine-nucleoside phosphorylase activity Source: PomBase

    GO - Biological processi

    1. NAD biosynthesis via nicotinamide riboside salvage pathway Source: PomBase
    2. purine nucleoside catabolic process Source: PomBase

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_206933. Purine salvage.
    REACT_223903. Purine catabolism.
    UniPathwayiUPA00606.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative purine nucleoside phosphorylase (EC:2.4.2.1)
    Short name:
    PNP
    Alternative name(s):
    Inosine phosphorylase
    Inosine-guanosine phosphorylase
    Gene namesi
    ORF Names:SPAC1805.16c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1805.16c.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Putative purine nucleoside phosphorylasePRO_0000316221Add
    BLAST

    Proteomic databases

    MaxQBiQ9UTG1.

    Interactioni

    Protein-protein interaction databases

    BioGridi278897. 10 interactions.
    MINTiMINT-4710355.
    STRINGi4896.SPAC1805.16c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UTG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000045183.
    KOiK03783.
    OMAiDHINMLP.
    OrthoDBiEOG72C59D.
    PhylomeDBiQ9UTG1.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    InterProiIPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
    IPR011268. Purine_phosphorylase.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PTHR11904:SF9. PTHR11904:SF9. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000477. PurNPase. 1 hit.
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01700. PNPH. 1 hit.
    TIGR01697. PNPH-PUNA-XAPA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UTG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTATSFLHQA KQQPHHTEPY IKALEAREYI IEQVPEELSK PKVAIICGSG    50
    LGTLASGLSA PVYEVPYEDI PHFHVSHVPG HASKLYFAFL GEKRVPTMIL 100
    AGRYHSYEGY PIEATTFPVR LMKVMGVEVM VVTNAAGGLN QGFKVGDLMI 150
    LKDHINFPGL AGMNPLRGPN AHEFGVRFPP LSDAYDLELR KLVYDAAKAH 200
    KVSRTIHEGC YAFVSGPCFE TRAESRMLAL MGADCVGMST VPEVVVARHC 250
    GIRVLAISLV TNNVVVEESP SAKDLVEVDS NVMSKGAANH LEVLEVGIAA 300
    AADVRTMVET IVNFI 315
    Length:315
    Mass (Da):34,239
    Last modified:May 1, 2000 - v1
    Checksum:i9B7DC695C71D7BC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB55857.1.
    PIRiT37901.
    RefSeqiNP_593927.1. NM_001019356.2.

    Genome annotation databases

    EnsemblFungiiSPAC1805.16c.1; SPAC1805.16c.1:pep; SPAC1805.16c.
    GeneIDi2542435.
    KEGGispo:SPAC1805.16c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB55857.1 .
    PIRi T37901.
    RefSeqi NP_593927.1. NM_001019356.2.

    3D structure databases

    ProteinModelPortali Q9UTG1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278897. 10 interactions.
    MINTi MINT-4710355.
    STRINGi 4896.SPAC1805.16c-1.

    Proteomic databases

    MaxQBi Q9UTG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1805.16c.1 ; SPAC1805.16c.1:pep ; SPAC1805.16c .
    GeneIDi 2542435.
    KEGGi spo:SPAC1805.16c.

    Organism-specific databases

    PomBasei SPAC1805.16c.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000045183.
    KOi K03783.
    OMAi DHINMLP.
    OrthoDBi EOG72C59D.
    PhylomeDBi Q9UTG1.

    Enzyme and pathway databases

    UniPathwayi UPA00606 .
    Reactomei REACT_206933. Purine salvage.
    REACT_223903. Purine catabolism.

    Miscellaneous databases

    NextBioi 20803492.
    PROi Q9UTG1.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    InterProi IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
    IPR011268. Purine_phosphorylase.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    PTHR11904:SF9. PTHR11904:SF9. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000477. PurNPase. 1 hit.
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01700. PNPH. 1 hit.
    TIGR01697. PNPH-PUNA-XAPA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPNPH_SCHPO
    AccessioniPrimary (citable) accession number: Q9UTG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3