Reviewed, UniProtKB/Swiss-Prot Q9UTB5 (PSD1_SCHPO)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase 1 beta chain
    2- Recommended name:
            Phosphatidylserine decarboxylase 1 alpha chain

Gene names

Name:	psd1
ORF Names:	SPAC25B8.03

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in the regulation of phospholipid biosynthesis and interorganelle trafficking of phosphatidylserine By similarity.
Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.
Subcellular location	Mitochondrion inner membrane By similarity.
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from genetic interaction. Source: GeneDB_SPombe regulation of cell morphogenesis Inferred from genetic interaction. Source: GeneDB_SPombe regulation of cytokinesis Inferred from genetic interaction. Source: GeneDB_SPombe
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear envelope Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	phosphatidylserine decarboxylase activity Inferred from genetic interaction. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 87	87	Mitochondrion Potential
	Chain	88 – 516	429	Phosphatidylserine decarboxylase proenzyme 1, mitochondrial		PRO_0000316032
	Chain	88 – 487	400	Phosphatidylserine decarboxylase 1 beta chain By similarity		PRO_0000316033
	Chain	488 – 516	29	Phosphatidylserine decarboxylase 1 alpha chain By similarity		PRO_0000316034
Sites
	Site	487 – 488	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	488	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UTB5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: FFE4579558985FB9	FASTA	516	58,464
	10 20 30 40 50 60 MRPRQRFRRF HPRWSKVNLR GFGGVGALKG VKALNGMNVR VSMRLKWISN RIHRIRRSRR 70 80 90 100 110 120 LGRLSISVRP NGSWQVYLLS SLPLRSLSRV WGQFNRAHLP TFLRTPGFKL YAWVFGCNLS 130 140 150 160 170 180 ELKDPDLTHY RNFQDFFCRE LRPETRPVDP VSPVVSPVDG RIVCQGVVDN NRIQHVKGLS 190 200 210 220 230 240 YSLEALLGGI SSSNPLVVNF EDEITPDLIQ KHEQFAEQHS ISLNSNNRYR KADASAAVVD 250 260 270 280 290 300 EHSDEEALLC AFTDHPHFYL NDSRNSLNYF CPFSAFEDIS NSVRSSCGKR LSPSSNFDLN 310 320 330 340 350 360 NLGGDDDLRS ESSSDFESAP ASILEHEPTN WDDWVQEADV TDIDSLPWHN IRPGNKLFYS 370 380 390 400 410 420 VIYLAPGDYH RFHSPADWVI ESRRHFSGEL FSVSPFLARR LHNLFVLNER VALLGRYEHG 430 440 450 460 470 480 FMSMIPVGAT NVGSIVINCD PTLSTNRLVL RKKSLGTFQE AVYKNASPVL DGMPVSRGEQ 490 500 510 VGGFQLGSTV VLVFEAPADF EFSTYQGQYV RVGEAL

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB61769.1.
PIR	T50190.
RefSeq	NP_594463.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UTB5.
Genome annotation databases
GeneID	2541447.
GenomeReviews	Gene locus psd1 in contig CU329670_GR.
KEGG	spo:SPAC25B8.03.
NMPDR	fig|4896.1.peg.4433.
Organism-specific databases
GeneDB_Spombe	SPAC25B8.03.
Phylogenomic databases
OMA	NERATRT.
Enzyme and pathway databases
BRENDA	4.1.1.65. 653.
Gene expression databases
ArrayExpress	Q9UTB5.
Family and domain databases
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD1_SCHPO

Accession

Primary (citable) accession number: Q9UTB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)