Reviewed,
UniProtKB/Swiss-Prot Q9UTB2 (SYSM_SCHPO)
Last modified
February 9, 2010.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Seryl-tRNA synthetase, mitochondrial EC=6.1.1.11 Alternative name(s): Seryl-tRNA(Ser/Sec) synthetase Serine--tRNA ligase Short name=SerRS | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 454 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity. UniProtKB Q9N0F3 |
| Catalytic activity | ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). UniProtKB Q9N0F3 ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec). UniProtKB Q9N0F3 |
| Pathway | Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. UniProtKB Q9N0F3 |
| Subunit structure | Homodimer. The tRNA molecule probably binds across the dimer By similarity. UniProtKB Q9N0F3 |
| Subcellular location | |
| Domain | Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity. UniProtKB P0A8L1 |
| Sequence similarities | Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Mitochondrion |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | seryl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-tRNA ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 454 | 454 | Seryl-tRNA synthetase, mitochondrial | PRO_0000315879 | |||||
Regions | |||||||||
| Nucleotide binding | 292 – 294 | 3 | ATP By similarity UniProtKB Q9N0F3 | ||||||
| Nucleotide binding | 379 – 382 | 4 | ATP By similarity UniProtKB Q9N0F3 | ||||||
| Region | 262 – 264 | 3 | Serine binding By similarity UniProtKB Q9N0F3 | ||||||
Sites | |||||||||
| Binding site | 315 | 1 | Serine By similarity UniProtKB Q9N0F3 | ||||||
| Binding site | 413 | 1 | Serine By similarity UniProtKB Q9N0F3 | ||||||
Sequences
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References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329670 Genomic DNA. Translation: CAB61772.1. |
| PIR | T50193. |
| RefSeq | NP_594466.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1WLE based on UniProtKB Q9N0F3. |
| SMR | Q9UTB2. Positions 24-449, 117-450. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9UTB2. |
Genome annotation databases | |
| GeneID | 2541567. |
| GenomeReviews | Gene locus dia4 in contig CU329670_GR. |
| KEGG | spo:SPAC25B8.06c. |
| NMPDR | fig|4896.1.peg.4436. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC25B8.06c. |
Phylogenomic databases | |
| eggNOG | fuNOG06563. |
| HOGENOM | HBG629391. |
| OMA | PKFDFKP. |
| OrthoDB | EOG9R51JX. |
| PhylomeDB | Q9UTB2. |
Enzyme and pathway databases | |
| BRENDA | 6.1.1.11. 653. |
Gene expression databases | |
| ArrayExpress | Q9UTB2. |
Family and domain databases | |
| InterPro | IPR002314. aa-tRNA-synt_IIb_cons-dom. IPR006195. aa-tRNA-synth_II_cons-dom. IPR002317. Ser-tRNA-synth_IIa. IPR018156. Ser-tRNA-synth_IIa_C. IPR015866. Ser-tRNA-synth_IIa_N. IPR010978. tRNA_bd_arm. [Graphical view] |
| PANTHER | PTHR11778. tRNA-synt_ser. 1 hit. |
| Pfam | PF02403. Seryl_tRNA_N. 1 hit. PF00587. tRNA-synt_2b. 1 hit. [Graphical view] |
| PIRSF | PIRSF001529. Ser-tRNA-synth_IIa. 1 hit. |
| PRINTS | PR00981. TRNASYNTHSER. |
| TIGRFAMs | TIGR00414. serS. 1 hit. |
| PROSITE | PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SYSM_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q9UTB2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


