Reviewed, UniProtKB/Swiss-Prot Q9UTA4 (POPI_SCHPO)

Names and origin

Protein names

Recommended name:
    Ribonucleases P/MRP protein subunit pop1
    EC=3.1.26.5

Gene names

Name:	pop1
ORF Names:	SPAC25B8.16

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	698 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP complexes By similarity.
Subcellular location	Nucleus › nucleolus. Ref.2 Ref.3
Sequence similarities	Belongs to the POP1 family.

Ontologies

Keywords
Biological process	rRNA processing tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW tRNA 5'-leader removal Inferred from electronic annotation. Source: InterPro
Cellular component	nucleolus Ref.3 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 698	698	Ribonucleases P/MRP protein subunit pop1		PRO_0000337990

Sequences

	Sequence		Length	Mass (Da)
	Q9UTA4-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 987A6BD0BA2C2427	FASTA	698	79,931
	10 20 30 40 50 60 MKRSTGGTQP KGLNVKRSKL ADARFIEVES PALSNGAVDL KKFIESRSFE ITALQDAMKR 70 80 90 100 110 120 SKESSAQRAF QALPRCLRRR AASHNIKRIP KGLRDRALYE MQLSSSSTLP IAPSRQRLKR 130 140 150 160 170 180 FIKRLRRKLA KSGETKAIDS TGSLVTDNST DDSRIPSLAA VKLIRGKFAG RQLRKVWLPT 190 200 210 220 230 240 HLWVCKRAHM INAWGYAIPE KPTEKSYRPT HRAAFRKDAI AFDMSYEPLF CISGPYEALK 250 260 270 280 290 300 EKFGNSFANG LPPVFLNSSR SFTSYLVKSD IHELICPCFL QWNNPTEDDK KQIPVKNPTE 310 320 330 340 350 360 CVQLVIRLHP SAFLQAWNYL SGIAVLDDRI AMHDWRLDLA SFDIHGPDSN IMLHKVFDDV 370 380 390 400 410 420 ELDEAGKVWQ SISNYSSACL PMGASISVKA LVNTRCDKNL SEKGEKSLLD SAENSLPASA 430 440 450 460 470 480 NQYSTHFRYW ERQEIPSFAV FENKNRHTHE KKSSEKEVIP VYITYRKEWN GLTVILPWDY 490 500 510 520 530 540 AKFVWRKMMY QKGIRFGGLE NLHQIAFEKR MPFFPIDYPD TISGQLCEEE RKKRNEDSWK 550 560 570 580 590 600 RRPPAKRVNY QKFGDNFSEI GNPFCCDWVY LNEMVKASRD EDKTLQLVRV QVQLVQRGSL 610 620 630 640 650 660 QDRARIYCLS DDELSKWKTI IYKENLTAEN LLYPKCPNET AIIGFVTTGN FNLNAGKPSG 670 680 690 IANVLAKTIK NEKSGYCIIR NVGCSVPRLA QWKFNQSH

References

[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library." Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y. Genes Cells 5:169-190(2000) [PubMed: 10759889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-61, SUBCELLULAR LOCATION. Strain: ATCC 38364 / 968.
[3]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB61782.1. AB027831 Genomic DNA. Translation: BAA87135.1. Different initiation.
PIR	T50203.
RefSeq	NP_594476.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2541548.
GenomeReviews	Gene locus pop1 in contig CU329670_GR.
KEGG	spo:SPAC25B8.16.
NMPDR	fig|4896.1.peg.4446.
Organism-specific databases
GeneDB_Spombe	SPAC25B8.16.
Phylogenomic databases
OMA	WNAKRSH.
Gene expression databases
ArrayExpress	Q9UTA4.
Family and domain databases
InterPro	IPR012590. POPLD. IPR009723. RNase_P/MRP_POP1. [Graphical view]
Pfam	PF06978. POP1. 1 hit. PF08170. POPLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POPI_SCHPO

Accession

Primary (citable) accession number: Q9UTA4
Secondary accession number(s): Q9UU39

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)