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Protein

NADH kinase pos5, mitochondrial

Gene

pos5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphorylates both NADH and NAD+, with a preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH (By similarity).By similarity

Catalytic activityi

ATP + NADH = ADP + NADPH.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NADH kinase pos5, mitochondrial (EC:2.7.1.86)
Gene namesi
Name:pos5
ORF Names:SPAC323.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC323.01c.
PomBaseiSPAC323.01c. pos5.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionSequence analysisAdd
BLAST
Chaini43 – 386344NADH kinase pos5, mitochondrialPRO_0000316603Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi279603. 1 interaction.
MINTiMINT-4709923.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000172029.
InParanoidiQ9UT98.
KOiK19386.
OMAiGLSMDGQ.
OrthoDBiEOG092C2DOX.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UT98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRAANGFRI SVRNTAVCLA PNFRQLKGFS IINLGSLQYF RYNSVYSKSI
60 70 80 90 100
RLVNTLENRI VPVYKECASP QSIGGKSNLK QLQWPKPPKN ILILKKRMDE
110 120 130 140 150
RVDHCFETLV QHLQQTYPDI CIITETDVAK KFSYLNLYTW TEISDLEQKV
160 170 180 190 200
DAIITVGGDG TILHAASLFA RSGMPPILSF SLGTLGFLLP FDFGSFQTAF
210 220 230 240 250
ADFYNSRSFV LMRMRLRVAM KTKLYNESIY AMNEMHIHRG LSPHMAVLKV
260 270 280 290 300
FVNDKFLTEA VADGLIISTP TGSTAYSLSS GGPIVHPSIN ALLLTPICPN
310 320 330 340 350
SLSFRPVLFP DTFKISIETS NKSRVRPQLS IDGRPLGLTD IGQRIDITSV
360 370 380
KDNAIPCIIR SHKEDDWVSD IVSLLRWNHP FHRKGW
Length:386
Mass (Da):43,500
Last modified:February 22, 2012 - v2
Checksum:iC15B8068C6935517
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB53404.2.
PIRiT38638.
RefSeqiNP_594371.2. NM_001019792.2.

Genome annotation databases

EnsemblFungiiSPAC323.01c.1; SPAC323.01c.1:pep; SPAC323.01c.
GeneIDi2543173.
KEGGispo:SPAC323.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB53404.2.
PIRiT38638.
RefSeqiNP_594371.2. NM_001019792.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279603. 1 interaction.
MINTiMINT-4709923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC323.01c.1; SPAC323.01c.1:pep; SPAC323.01c.
GeneIDi2543173.
KEGGispo:SPAC323.01c.

Organism-specific databases

EuPathDBiFungiDB:SPAC323.01c.
PomBaseiSPAC323.01c. pos5.

Phylogenomic databases

HOGENOMiHOG000172029.
InParanoidiQ9UT98.
KOiK19386.
OMAiGLSMDGQ.
OrthoDBiEOG092C2DOX.

Miscellaneous databases

PROiQ9UT98.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPOS5_SCHPO
AccessioniPrimary (citable) accession number: Q9UT98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 22, 2012
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.