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Protein

Probable proteasome subunit alpha type-5

Gene

pup2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-6798695 Neutrophil degranulation
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.975

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-5 (EC:3.4.25.1)
Gene namesi
Name:pup2
ORF Names:SPAC323.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC323.02c
PomBaseiSPAC323.02c pup2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241281 – 247Probable proteasome subunit alpha type-5Add BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UT97
PaxDbiQ9UT97
PRIDEiQ9UT97

PTM databases

iPTMnetiQ9UT97

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi279634, 6 interactors
IntActiQ9UT97, 3 interactors
MINTiQ9UT97
STRINGi4896.SPAC323.02c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UT97
SMRiQ9UT97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091085
InParanoidiQ9UT97
KOiK02729
OMAiFQVEYAR
OrthoDBiEOG092C47D8
PhylomeDBiQ9UT97

Family and domain databases

CDDicd03753 proteasome_alpha_type_5, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR033812 Proteasome_alpha_type_5
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UT97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGV KTKDAVVLGV
60 70 80 90 100
EKRLTSPLME SHSVEKLFEI DSHIGCAISG LTADARTIIE HARVQTQNHR
110 120 130 140 150
FTYDEPQGIE STTQSICDLA LRFGEGEDGE ERIMSRPFGV ALLIAGIDEH
160 170 180 190 200
GPQLYHSEPS GTYFRYEAKA IGSGSEPAKS ELVKEFHKDM TLEEAEVLIL
210 220 230 240
KVLRQVMEEK LDSKNVQLAK VTAEGGFHIY NDEEMADAVA REQQRMD
Length:247
Mass (Da):27,573
Last modified:May 1, 2000 - v1
Checksum:i713E1AB3A3ADE658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB53405.1
PIRiT38639
RefSeqiNP_594372.1, NM_001019793.2

Genome annotation databases

EnsemblFungiiSPAC323.02c.1; SPAC323.02c.1:pep; SPAC323.02c
GeneIDi2543205
KEGGispo:SPAC323.02c

Similar proteinsi

Entry informationi

Entry nameiPSA5_SCHPO
AccessioniPrimary (citable) accession number: Q9UT97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health