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Protein

Probable translation initiation factor eIF-2B subunit beta

Gene

tif222

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: PomBase
  • translation initiation factor activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor eIF-2B subunit beta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit beta
Gene namesi
Name:tif222
ORF Names:SPAC343.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC343.14c.
PomBaseiSPAC343.14c. tif222.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • eukaryotic translation initiation factor 2B complex Source: PomBase
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173231 – 393Probable translation initiation factor eIF-2B subunit betaAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106Phosphoserine1 Publication1
Modified residuei108Phosphoserine1 Publication1
Modified residuei112Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UT76.
PRIDEiQ9UT76.

PTM databases

iPTMnetiQ9UT76.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Protein-protein interaction databases

BioGridi279470. 7 interactors.
DIPiDIP-61959N.
MINTiMINT-4709788.

Structurei

Secondary structure

1393
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Helixi11 – 21Combined sources11
Helixi28 – 45Combined sources18
Helixi51 – 68Combined sources18
Helixi73 – 96Combined sources24
Helixi141 – 144Combined sources4
Helixi170 – 184Combined sources15
Helixi187 – 191Combined sources5
Helixi192 – 197Combined sources6
Beta strandi204 – 209Combined sources6
Helixi212 – 222Combined sources11
Beta strandi228 – 232Combined sources5
Turni235 – 237Combined sources3
Helixi239 – 251Combined sources13
Beta strandi255 – 259Combined sources5
Helixi261 – 263Combined sources3
Helixi264 – 267Combined sources4
Helixi268 – 270Combined sources3
Beta strandi273 – 276Combined sources4
Beta strandi279 – 281Combined sources3
Beta strandi287 – 290Combined sources4
Helixi293 – 302Combined sources10
Beta strandi307 – 310Combined sources4
Helixi313 – 315Combined sources3
Helixi324 – 327Combined sources4
Helixi333 – 335Combined sources3
Helixi342 – 346Combined sources5
Beta strandi347 – 350Combined sources4
Beta strandi355 – 358Combined sources4
Helixi360 – 362Combined sources3
Beta strandi365 – 368Combined sources4
Beta strandi371 – 373Combined sources3
Helixi375 – 377Combined sources3
Helixi378 – 385Combined sources8
Helixi388 – 391Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99C/D1-393[»]
ProteinModelPortaliQ9UT76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000208487.
InParanoidiQ9UT76.
KOiK03754.
OMAiFVSPHEV.
OrthoDBiEOG092C3UWH.
PhylomeDBiQ9UT76.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UT76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTINVEHTY PAVSSLIADL KSRKVQGPFA VAVETALVMR QVISQTRWST
60 70 80 90 100
VDQLIDTVRA VGSTLVKAQP TEFSCGNIIR RILRLIREEY QELLKTADEN
110 120 130 140 150
EKLIVSSSNS SSPSQKRDIP SNEKLVQSHE PVSVQMYSSM LNLLGRPTLE
160 170 180 190 200
SPTHSKTVGD SRVTGGMDMR AVIISGIQDV IDELDKINTD IEVQSMDHLH
210 220 230 240 250
SNEIILTQGC SKTVEAFLRF AAKKRKFSVI VAEGFPNNQK GSHAMAKRLA
260 270 280 290 300
QAGIDTTVIS DATIFAIMSR VNKVILGTHA ILGNGGLVTY SGAQLVAQAA
310 320 330 340 350
RHHATPVVVC SGIYKLSPVY PYDLESIIQL SSPDKIMSFN EGDLISRAEI
360 370 380 390
LNPYYDYIPP DLVDLFITNL GGYPPSYLYR IMNDTYDASD TIL
Length:393
Mass (Da):43,221
Last modified:May 1, 2000 - v1
Checksum:i19F324EF0135628B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52277.1.
PIRiT38663.
RefSeqiNP_593435.1. NM_001018868.2.

Genome annotation databases

EnsemblFungiiSPAC343.14c.1; SPAC343.14c.1:pep; SPAC343.14c.
GeneIDi2543035.
KEGGispo:SPAC343.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52277.1.
PIRiT38663.
RefSeqiNP_593435.1. NM_001018868.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99C/D1-393[»]
ProteinModelPortaliQ9UT76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279470. 7 interactors.
DIPiDIP-61959N.
MINTiMINT-4709788.

PTM databases

iPTMnetiQ9UT76.

Proteomic databases

MaxQBiQ9UT76.
PRIDEiQ9UT76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC343.14c.1; SPAC343.14c.1:pep; SPAC343.14c.
GeneIDi2543035.
KEGGispo:SPAC343.14c.

Organism-specific databases

EuPathDBiFungiDB:SPAC343.14c.
PomBaseiSPAC343.14c. tif222.

Phylogenomic databases

HOGENOMiHOG000208487.
InParanoidiQ9UT76.
KOiK03754.
OMAiFVSPHEV.
OrthoDBiEOG092C3UWH.
PhylomeDBiQ9UT76.

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Miscellaneous databases

PROiQ9UT76.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BB_SCHPO
AccessioniPrimary (citable) accession number: Q9UT76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.