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Q9UT61

- MAN1_SCHPO

UniProt

Q9UT61 - MAN1_SCHPO

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Protein
Alpha-mannosidase
Gene
ams1, mns2, SPAC513.05
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Degrades free oligosaccharides in the vacuole By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi290 – 2901Zinc By similarity
Metal bindingi292 – 2921Zinc By similarity
Active sitei402 – 4021Nucleophile By similarity
Metal bindingi402 – 4021Zinc By similarity
Metal bindingi615 – 6151Zinc By similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: PomBase
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
  2. oligosaccharide catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase (EC:3.2.1.24)
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Gene namesi
Name:ams1
Synonyms:mns2
ORF Names:SPAC513.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC513.05.

Subcellular locationi

Cytoplasm. Vacuole By similarity 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. fungal-type vacuole membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10771077Alpha-mannosidase
PRO_0000363389Add
BLAST

Proteomic databases

MaxQBiQ9UT61.

Interactioni

Protein-protein interaction databases

MINTiMINT-4709700.
STRINGi4896.SPAC513.05-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UT61.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0383.
HOGENOMiHOG000048425.
KOiK01191.
OMAiCHMAPSE.
OrthoDBiEOG79SF5G.
PhylomeDBiQ9UT61.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UT61-1 [UniParc]FASTAAdd to Basket

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MTLFPVLNNT PVGKQVDSIY ESRLDQFLSE GQYRDFNLPS VYDHARIDNP     50
SGDVNNDLSK GFVDLKVYRV PDLSRPSFNE VVGHKKFDET ASKGDTFGPS 100
WATFWFEVHI RLPKSWAKYE QVIFQWNCDN EGLVYSQDGV PLQAFSGSER 150
TDFILPDSWK TTEDTFYIEM ACNGMFGTGA GSQIAPPDPN RYFTLTKADL 200
VAPNLPAMAL AYDFLLMQQC VKQLPSNCWQ KYKARQICND IMNTFHPNDL 250
STINECRNLA KAFLGNDIDS EAVFEKNNDK ANVFAIGHCH IDTAWLWPFA 300
ETRRKIVRSW ATQMNIMDRY PEYQFVCSQA LQYLWLKEDH PDVFEKLKEY 350
VNQNKFIPIG GSWVEHDTNI PNGESLIRQF LLGQHFFEKE FGVRCRTFWL 400
PDTFGYSSQI PQICRLCGMD RFLTQKLSWN NINSFPTSTF NWVALDGSQV 450
ICHMPPANTY TADTNVNDVL HSIDQHKNLV NDQAGLLVFG IGDGGGGPTP 500
EMLEKLRRCK GIANTVGYLP NVKLGNTVDE FFDGILKRTN AGQTLPSWNG 550
ELYFEFHRGT YTTQAELKKL MRKVEIALHD AEYVSTLASI FSKDYSYPKE 600
SLQDLWRDTL LCQFHDVLPG SCIEMVYKDA IPIMSKVLKN TEALLWQAIE 650
QLGFKKASSS DNKEQLCLLN TLPWNVRGVI TETEENKLVY FESCDGKGIL 700
TAAHTSLKHP AAAYQKDDNF ILVNDHLRVT IAPNGLILSL FDLHKEREIL 750
DLKSGKNHAG ANQYVLFEDT PLSWQAWDTE VFSLEKYEVL DKGKVSIKES 800
GPLRASVVVD IPISELSHMK ATISLEGYND CSEFTGVNFT CEVDWHESCK 850
FLKVEFPVDI HSEFASYETQ FGITKRPTHY NTSWDVAKFE VCHQKFADYS 900
DFTYGVSVLN DCKYGFSTHG NLMRLSLLRS PKQPDAHADM GKHTIRYAVY 950
PHSKPLDSST VRAAHKFNSN FRLLTRASDT ANLDIFDAFQ LVGEPNVILS 1000
HIKMAEKGKS IILRVYESLG GKSRARLVIK SLTVASVTKC NGLEEDLEEL 1050
CTLKSNDYYE VPIELRAFEI ATFKVNL 1077
Length:1,077
Mass (Da):122,438
Last modified:May 1, 2000 - v1
Checksum:i8774DDF4A2194A46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB58728.1.
PIRiT38900.
RefSeqiNP_593979.1. NM_001019405.2.

Genome annotation databases

EnsemblFungiiSPAC513.05.1; SPAC513.05.1:pep; SPAC513.05.
GeneIDi2543485.
KEGGispo:SPAC513.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB58728.1 .
PIRi T38900.
RefSeqi NP_593979.1. NM_001019405.2.

3D structure databases

ProteinModelPortali Q9UT61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4709700.
STRINGi 4896.SPAC513.05-1.

Protein family/group databases

CAZyi GH38. Glycoside Hydrolase Family 38.

Proteomic databases

MaxQBi Q9UT61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC513.05.1 ; SPAC513.05.1:pep ; SPAC513.05 .
GeneIDi 2543485.
KEGGi spo:SPAC513.05.

Organism-specific databases

PomBasei SPAC513.05.

Phylogenomic databases

eggNOGi COG0383.
HOGENOMi HOG000048425.
KOi K01191.
OMAi CHMAPSE.
OrthoDBi EOG79SF5G.
PhylomeDBi Q9UT61.

Miscellaneous databases

NextBioi 20804497.
PROi Q9UT61.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAN1_SCHPO
AccessioniPrimary (citable) accession number: Q9UT61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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