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Q9UT49

- CID13_SCHPO

UniProt

Q9UT49 - CID13_SCHPO

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Protein

Poly(A) RNA polymerase cid13

Gene

cid13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Polymerase that creates the 3' poly(A) tail of suc22 mRNA.1 Publication

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101Magnesium or manganese; catalyticBy similarity
Metal bindingi112 – 1121Magnesium or manganese; catalyticBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. mRNA 3'-UTR binding Source: PomBase
  4. polynucleotide adenylyltransferase activity Source: PomBase

GO - Biological processi

  1. biological regulation Source: PomBase
  2. mRNA polyadenylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase cid13 (EC:2.7.7.19)
Short name:
PAP
Alternative name(s):
Caffeine-induced death protein 13
Polynucleotide adenylyltransferase cid13
Gene namesi
Name:cid13
ORF Names:SPAC821.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC821.04c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Poly(A) RNA polymerase cid13PRO_0000120313Add
BLAST

Proteomic databases

MaxQBiQ9UT49.
PRIDEiQ9UT49.

Interactioni

Subunit structurei

Interacts with pab1.1 Publication

Protein-protein interaction databases

BioGridi279633. 13 interactions.
IntActiQ9UT49. 6 interactions.
MINTiMINT-4709602.
STRINGi4896.SPAC821.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UT49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini275 – 33056PAP-associatedAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi551 – 5566Poly-Ser

Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated
Contains 1 PAP-associated domain.Curated

Phylogenomic databases

eggNOGiCOG5260.
InParanoidiQ9UT49.
OrthoDBiEOG75XGVD.
PhylomeDBiQ9UT49.

Family and domain databases

InterProiIPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UT49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNANCVGGC KFETRSFQYR RRIPYSLGAD PLPPVHPLSL KNLVDIDTDL
60 70 80 90 100
ISSQLYELYD SIILNDSGLE RRYAFVQKLE QILKKEFPYK NIKTSLFGST
110 120 130 140 150
QSLLASNASD IDLCIITDPP QCAPTTCEVS AAFARNGLKK VVCISTAKVP
160 170 180 190 200
IVKVWDSELQ LSCDCNINKT ISTLNTRLMR SYVLCDPRVR PLIVMIKYWA
210 220 230 240 250
KRRCLNDAAE GGTLTSYTIS CMVINFLQKR DPPILPSLQM LPHLQDSSTM
260 270 280 290 300
TDGLDVSFFD DPDLVHGFGD KNEESLGILF VEFFRFFGYL FDYEHFVLSI
310 320 330 340 350
RHGTFLSKRA KGWQFQLNNF LCVEEPFHTS RNLANTADEI TMKGIQLEFR
360 370 380 390 400
RVFRLLAYNC NVDDACSQFT FPSLTDTSFM DDYVNELQLE IVPGFSHGRD
410 420 430 440 450
SSDTSCTESP PEPSHFAWAF DPYNATASPY YNQNINSSID YSSIYSNDVP
460 470 480 490 500
AIPPNVPYTF VDPYTYACYI NNNSYLPPSY MDFYTWYNSP YPKSSHHFDE
510 520 530 540 550
RHGGDRHEKN LSNSRRYSRN KFHKKKQSSG PFQYYPDAFS FTPTDNNSPP
560 570
SNSSSSEVVS PVSLHSEPVL STVQAFKS
Length:578
Mass (Da):65,771
Last modified:May 1, 2000 - v1
Checksum:iA572D21E13552351
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB57438.1.
PIRiT41715.
RefSeqiNP_593157.1. NM_001018555.2.

Genome annotation databases

EnsemblFungiiSPAC821.04c.1; SPAC821.04c.1:pep; SPAC821.04c.
GeneIDi2543204.
KEGGispo:SPAC821.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB57438.1 .
PIRi T41715.
RefSeqi NP_593157.1. NM_001018555.2.

3D structure databases

ProteinModelPortali Q9UT49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279633. 13 interactions.
IntActi Q9UT49. 6 interactions.
MINTi MINT-4709602.
STRINGi 4896.SPAC821.04c-1.

Proteomic databases

MaxQBi Q9UT49.
PRIDEi Q9UT49.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC821.04c.1 ; SPAC821.04c.1:pep ; SPAC821.04c .
GeneIDi 2543204.
KEGGi spo:SPAC821.04c.

Organism-specific databases

PomBasei SPAC821.04c.

Phylogenomic databases

eggNOGi COG5260.
InParanoidi Q9UT49.
OrthoDBi EOG75XGVD.
PhylomeDBi Q9UT49.

Miscellaneous databases

NextBioi 20804227.

Family and domain databases

InterProi IPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view ]
Pfami PF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA."
    Saitoh S., Chabes A., McDonald W.H., Thelander L., Yates J.R. III, Russell P.
    Cell 109:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PAB1, SUBCELLULAR LOCATION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCID13_SCHPO
AccessioniPrimary (citable) accession number: Q9UT49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3