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Q9UT45

- ENG1_SCHPO

UniProt

Q9UT45 - ENG1_SCHPO

Protein

Endo-1,3(4)-beta-glucanase 1

Gene

eng1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Has a role in cell separation where it is required for the degradation of the primary septum after completion of cytokinesis.1 Publication

    Catalytic activityi

    Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

    GO - Molecular functioni

    1. glucan endo-1,3-beta-D-glucosidase activity Source: PomBase
    2. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
    3. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
    4. polysaccharide binding Source: PomBase

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. extracellular polysaccharide metabolic process Source: PomBase
    3. mitotic cytokinetic cell separation Source: PomBase
    4. oligosaccharide catabolic process Source: PomBase
    5. primary cell septum disassembly Source: PomBase

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division

    Protein family/group databases

    CAZyiCBM52. Carbohydrate-Binding Module Family 52.
    GH81. Glycoside Hydrolase Family 81.
    mycoCLAPiLAM81A_SCHPO.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endo-1,3(4)-beta-glucanase 1 (EC:3.2.1.6)
    Short name:
    Endo-1,3-beta-glucanase 1
    Short name:
    Endo-1,4-beta-glucanase 1
    Alternative name(s):
    Laminarinase-1
    Gene namesi
    Name:eng1
    ORF Names:SPAC821.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC821.09.

    Subcellular locationi

    Cell septum 2 Publications
    Note: Localized in a ring-like structure around the septum.

    GO - Cellular componenti

    1. cell septum surface Source: PomBase
    2. cell surface Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 1016996Endo-1,3(4)-beta-glucanase 1PRO_0000012132Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9UT45.

    Interactioni

    Protein-protein interaction databases

    BioGridi279801. 17 interactions.
    STRINGi4896.SPAC821.09-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UT45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi752 – 956205Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 81 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5498.
    OMAiIHMLPLM.
    OrthoDBiEOG7MSMXB.
    PhylomeDBiQ9UT45.

    Family and domain databases

    InterProiIPR018909. CBM_septum.
    IPR005200. Glyco_hydro_81.
    [Graphical view]
    PfamiPF10645. Carb_bind. 3 hits.
    PF03639. Glyco_hydro_81. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UT45-1 [UniParc]FASTAAdd to Basket

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    MSSYLRSFIF GLLTISLAQC SPILKDTKDT KFSTGSNISL KKRDTNVFDS     50
    VVDTINPASY FGTVSHPVTP AGVSTDSLSS PIETNKFFDN NLLGSRTNFM 100
    YADPFRYWWQ SSDTMGGICI AHTDDNQRVM DTDDTIPSYY YEPIGICSLG 150
    FGASGITSNT DPIVDEIDQM SARFTFSWDS SSMQLTLTEG MAVTTAVYTN 200
    AIPQIFSSTL YINDFVEVPG TSAVQKYRVT MSDNHVWLIY IYGDSLTLTE 250
    STSQMLVGSN TFNGYIQIAK IPLGDGTAEA LYDTYAGVYI TGISISGYVE 300
    DAVGYYSFDF TTAGDTSVEP LFFLLPHQVD TAVSGTKVTS IVLASLVSGD 350
    MNAAAGNSIT FAEAIPQDIG FLPWSPTGGQ IGYSEEALEI IAEVAGTELG 400
    EDFSANSNLN SMYYSGKVLA KYAMLCVTIN DILGDETSSE QCIQKLEAAF 450
    ARFVDNQQIY PLTYDNTWKG VVSVAGLSGD SLADFGNSYY NDHHFHYGYF 500
    VFTAAVIGHI DPDWINTGNN KEWVNFLVRD VANPSSNDPY FPKHRMIDIY 550
    HGHGWASGLF ESNDGKDEES TSEDYNFFFG MKLWGQVIGD SDMEDRANII 600
    LGIERNALNK YMLYADGNVQ PTSMQPNYVA GITFMNKITH TTYFGTNIEY 650
    IQGIHMLPIT PISAFIRGPS FVLAEWNALL ASVIDYVDSG WRSLLYANLA 700
    IAEPEESYEY FSSSDFNTDY LDDGASRAWY LAYAAGLWAN DAVYYPVSSS 750
    STTTTSTSTG SVTTTSTTAT ASCTLPISYT STPTTTSISG TCNGATFDAS 800
    LYVCDGTVLC PIVNGVSYQN CNGACYNPSQ YGCDNGALGP VQSSSTTSSI 850
    TPTPTTTSSI TPTPTTTSTT TTAQSTGMQL CGSNYYDASS YYCDNDQLCP 900
    IIDGVDYLSC NGACYNPSQY VCSDGSLSPN TVTTTKATTT FTPTPTTTTT 950
    PTPTTTSATS TNVIAQCGSA WYDSQSYICY GNILCPIING SPLLACGNAC 1000
    YDSSIYGCSN GALVAA 1016
    Length:1,016
    Mass (Da):109,743
    Last modified:May 1, 2000 - v1
    Checksum:i9240CA34D35786FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB57443.1.
    AB027918 Genomic DNA. Translation: BAA87222.1. Sequence problems.
    PIRiT41720.
    RefSeqiNP_593162.1. NM_001018560.2.

    Genome annotation databases

    EnsemblFungiiSPAC821.09.1; SPAC821.09.1:pep; SPAC821.09.
    GeneIDi2543379.
    KEGGispo:SPAC821.09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB57443.1 .
    AB027918 Genomic DNA. Translation: BAA87222.1 . Sequence problems.
    PIRi T41720.
    RefSeqi NP_593162.1. NM_001018560.2.

    3D structure databases

    ProteinModelPortali Q9UT45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279801. 17 interactions.
    STRINGi 4896.SPAC821.09-1.

    Protein family/group databases

    CAZyi CBM52. Carbohydrate-Binding Module Family 52.
    GH81. Glycoside Hydrolase Family 81.
    mycoCLAPi LAM81A_SCHPO.

    Proteomic databases

    MaxQBi Q9UT45.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC821.09.1 ; SPAC821.09.1:pep ; SPAC821.09 .
    GeneIDi 2543379.
    KEGGi spo:SPAC821.09.

    Organism-specific databases

    PomBasei SPAC821.09.

    Phylogenomic databases

    eggNOGi COG5498.
    OMAi IHMLPLM.
    OrthoDBi EOG7MSMXB.
    PhylomeDBi Q9UT45.

    Miscellaneous databases

    NextBioi 20804394.

    Family and domain databases

    InterProi IPR018909. CBM_septum.
    IPR005200. Glyco_hydro_81.
    [Graphical view ]
    Pfami PF10645. Carb_bind. 3 hits.
    PF03639. Glyco_hydro_81. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-168, SUBCELLULAR LOCATION.
      Strain: ATCC 38364 / 968.
    3. "The endo-beta-1,3-glucanase eng1p is required for dissolution of the primary septum during cell separation in Schizosaccharomyces pombe."
      Martin-Cuadrado A.B., Duenas E., Sipiczki M., de Aldana C.R.V., del Rey F.
      J. Cell Sci. 116:1689-1698(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiENG1_SCHPO
    AccessioniPrimary (citable) accession number: Q9UT45
    Secondary accession number(s): Q9UTZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3