UniProtKB - Q9UT36 (GLO21_SCHPO)
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Protein
Probable hydroxyacylglutathione hydrolase C824.07
Gene
SPAC824.07
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.By similarity
Catalytic activityi
S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
: methylglyoxal degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes (R)-lactate from methylglyoxal.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Lactoylglutathione lyase (glo1)
- Probable hydroxyacylglutathione hydrolase C13B11.03c (SPCC13B11.03c), Probable hydroxyacylglutathione hydrolase C824.07 (SPAC824.07)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 63 | Zinc 1; via tele nitrogenBy similarity | 1 | |
Metal bindingi | 65 | Zinc 1; via pros nitrogenBy similarity | 1 | |
Metal bindingi | 67 | Zinc 2By similarity | 1 | |
Metal bindingi | 68 | Zinc 2; via tele nitrogenBy similarity | 1 | |
Metal bindingi | 118 | Zinc 1; via tele nitrogenBy similarity | 1 | |
Metal bindingi | 139 | Zinc 1By similarity | 1 | |
Metal bindingi | 139 | Zinc 2By similarity | 1 | |
Binding sitei | 148 | SubstrateBy similarity | 1 | |
Metal bindingi | 178 | Zinc 2; via tele nitrogenBy similarity | 1 |
GO - Molecular functioni
- hydroxyacylglutathione hydrolase activity Source: PomBase
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cellular detoxification Source: PomBase
- methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione Source: PomBase
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SPO-70268. Pyruvate metabolism. |
UniPathwayi | UPA00619; UER00676. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable hydroxyacylglutathione hydrolase C824.07 (EC:3.1.2.6)Alternative name(s): Glyoxalase II Short name: Glx II |
Gene namesi | ORF Names:SPAC824.07 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPAC824.07. |
PomBasei | SPAC824.07. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337689 | 1 – 256 | Probable hydroxyacylglutathione hydrolase C824.07Add BLAST | 256 |
Proteomic databases
MaxQBi | Q9UT36. |
PaxDbi | Q9UT36. |
PRIDEi | Q9UT36. |
PTM databases
iPTMneti | Q9UT36. |
Interactioni
Protein-protein interaction databases
BioGridi | 278908. 1 interactor. |
STRINGi | 4896.SPAC824.07.1. |
Structurei
3D structure databases
ProteinModelPortali | Q9UT36. |
SMRi | Q9UT36. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 178 – 180 | Substrate bindingBy similarity | 3 | |
Regioni | 250 – 253 | Substrate bindingBy similarity | 4 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | HOG000058041. |
InParanoidi | Q9UT36. |
KOi | K01069. |
OMAi | NYIWLLQ. |
OrthoDBi | EOG092C4YMK. |
PhylomeDBi | Q9UT36. |
Family and domain databases
CDDi | cd07723. hydroxyacylglutathione_hydrola. 1 hit. |
Gene3Di | 3.60.15.10. 1 hit. |
InterProi | View protein in InterPro IPR035680. Clx_II_MBL. IPR032282. HAGH_C. IPR001279. Metallo-B-lactamas. IPR036866. RibonucZ/Hydroxyglut_hydro. |
Pfami | View protein in Pfam PF16123. HAGH_C. 1 hit. PF00753. Lactamase_B. 1 hit. |
SMARTi | View protein in SMART SM00849. Lactamase_B. 1 hit. |
SUPFAMi | SSF56281. SSF56281. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9UT36-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFHITPIWM WKGTGNNYAY LLTCDKTKIT AIVDPAEPES VIPVIKEKTA
60 70 80 90 100
KKEIDLQYIL TTHHHYDHAG GNEDILSYFP SLKVYGGKNA SGVTYTPKDK
110 120 130 140 150
EIFKVGEVQV EALHTPCHTQ DSICYYVSSP SKRAVFTGDT LFTSGCGRFF
160 170 180 190 200
EGDAKQMDYA LNHVLAALPD DTVTYPGHEY TKSNAKFSST IFSTPELTKL
210 220 230 240 250
VDFCKNHEST TGHFTIGDEK KFNPFMCLGL ESVQKAVGSS DPITVMKKLR
DMKNAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA. Translation: CAB57337.1. |
PIRi | T39108. |
RefSeqi | NP_593446.1. NM_001018879.2. |
Genome annotation databases
EnsemblFungii | SPAC824.07.1; SPAC824.07.1:pep; SPAC824.07. |
GeneIDi | 2542447. |
KEGGi | spo:SPAC824.07. |
Similar proteinsi
Entry informationi
Entry namei | GLO21_SCHPO | |
Accessioni | Q9UT36Primary (citable) accession number: Q9UT36 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 28, 2018 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |