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Protein

Guanosine-diphosphatase

Gene

gdp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.1 Publication

Catalytic activityi

GDP + H2O = GMP + phosphate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei256Proton acceptorBy similarity1

GO - Molecular functioni

  • guanosine-diphosphatase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW
  • uridine-diphosphatase activity Source: PomBase

GO - Biological processi

  • protein N-linked glycosylation Source: PomBase

Keywordsi

Molecular functionHydrolase
LigandCalcium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-8850843 Phosphate bond hydrolysis by NTPDase proteins
UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-diphosphatase (EC:3.6.1.42)
Short name:
GDPase
Gene namesi
Name:gdp1
ORF Names:SPAC824.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC824.08
PomBaseiSPAC824.08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini34 – 556LumenalSequence analysisAdd BLAST523

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099181 – 556Guanosine-diphosphataseAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UT35
PaxDbiQ9UT35
PRIDEiQ9UT35

Interactioni

Protein-protein interaction databases

BioGridi278325, 21 interactors
STRINGi4896.SPAC824.08.1

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000206583
InParanoidiQ9UT35
KOiK01526
OMAiTPRGYLT
OrthoDBiEOG092C1F34
PhylomeDBiQ9UT35

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UT35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTMKSIAR RKALLIALSI FAVTFILWNG FPGSSNRPLP SSNDEFHYED
60 70 80 90 100
IELPSGYRSE GEVVDLLNPK DELEEPLFSE EPLFPVTTSI PTKTAVSKPK
110 120 130 140 150
IAPTSAAKDV TFSSSIDSDD CSVAYDNSKP VRQYVLMIDA GSTGSRVHVY
160 170 180 190 200
QFNNCNPSPK LEEEFFKMIE PGLSSFAGDP EGAAASLDPL LDYAMENVPE
210 220 230 240 250
EYRRCSPIAV KATAGLRLTG ESEAKAILKS VRQHLENDYP FPIVKDGVSI
260 270 280 290 300
LEGSMEGIYA WITINYLLGT LGGKATHSTV AVMDLGGAST QLVFEPRFAS
310 320 330 340 350
DGESLVDGDH KYVLDYNGEQ YELYQHSHLG YGLKEARKLI HKFVLNNAEA
360 370 380 390 400
LKESLELLGD STSIIHPCLH LNASLTHPDS KSEASEVVFV GPSLAHLSLQ
410 420 430 440 450
CRGIAEKALY KDKNCPVRPC SFNGVHQPKF TETFTDSPIY LISYFYDRMI
460 470 480 490 500
SLGMPSTFTI EDMKYLANSV CSGPTYWQDA FSLTDALKEL KEEPEWCLDL
510 520 530 540 550
NYMISLLSVG YEIPNNRQLH TAKKIDNKEL GWCLGASLSM LSEQNNGWNC

NVKEEI
Length:556
Mass (Da):61,589
Last modified:May 1, 2000 - v1
Checksum:i1D811E3D6A6BBB85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465240 Genomic DNA Translation: AAL69974.1
CU329670 Genomic DNA Translation: CAB57338.1
PIRiT39109
RefSeqiNP_593447.1, NM_001018880.2

Genome annotation databases

EnsemblFungiiSPAC824.08.1; SPAC824.08.1:pep; SPAC824.08
GeneIDi2541834
KEGGispo:SPAC824.08

Similar proteinsi

Entry informationi

Entry nameiGDA1_SCHPO
AccessioniPrimary (citable) accession number: Q9UT35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health