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Protein

Protein N-terminal and lysine N-methyltransferase efm7

Gene

nnt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei106S-adenosyl-L-methionineUniRule annotation1
Binding sitei137S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei162S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-terminal and lysine N-methyltransferase efm7UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Elongation factor methyltransferase 7UniRule annotation
Gene namesi
Name:nnt1By similarity
Synonyms:efm7UniRule annotation
ORF Names:SPAC8F11.09cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC8F11.09c
PomBaseiSPAC8F11.09c nnt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968991 – 255Protein N-terminal and lysine N-methyltransferase efm7Add BLAST255

Proteomic databases

MaxQBiQ9UT28
PaxDbiQ9UT28
PRIDEiQ9UT28

PTM databases

iPTMnetiQ9UT28

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC8F11.09c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UT28
SMRiQ9UT28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 86S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000199189
InParanoidiQ9UT28
KOiK17878
OMAiFYTHHRP
OrthoDBiEOG092C4ME2
PhylomeDBiQ9UT28

Family and domain databases

HAMAPiMF_03223 Methyltr_EFM7, 1 hit
InterProiView protein in InterPro
IPR025784 EFM7
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51560 SAM_MT_NNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UT28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNDFEGFG IFEEPEGFRP STPPPKEVLH TRVIVPNGPE EIKLRLVGSH
60 70 80 90 100
SLWAHYLWNS GIELANYIDK NPDTVRAKKV LELGAGAGLP SIVSAFDGAK
110 120 130 140 150
FVVSTDYPDP ALIDNLEHNV KQYAEIASKI SAVGYLWGSN IKEVMSNAGF
160 170 180 190 200
KDNEVFDILL LSDLVFNHTE HSKLIKSCKM AIEGNPNAVV YVFFTHHRPH
210 220 230 240 250
LAKKDMIFFD IAQSEGFQIE KILEEKRTPM FEEDPGAPEI RATVHGYKMT

IPIPV
Length:255
Mass (Da):28,490
Last modified:May 1, 2000 - v1
Checksum:i8E16DB39F6173EA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB52170.1
PIRiT39184
RefSeqiNP_593958.1, NM_001019385.2

Genome annotation databases

EnsemblFungiiSPAC8F11.09c.1; SPAC8F11.09c.1:pep; SPAC8F11.09c
GeneIDi2543599
KEGGispo:SPAC8F11.09c

Similar proteinsi

Entry informationi

Entry nameiEFM7_SCHPO
AccessioniPrimary (citable) accession number: Q9UT28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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