Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited

Gene

aro4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).By similarity

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited (aro4), Putative phospho-2-dehydro-3-deoxyheptonate aldolase (SPAC24H6.10c)
  2. Pentafunctional AROM polypeptide (aro1)
  3. Pentafunctional AROM polypeptide (aro1)
  4. Pentafunctional AROM polypeptide (aro1)
  5. Pentafunctional AROM polypeptide (aro1)
  6. Pentafunctional AROM polypeptide (aro1)
  7. Chorismate synthase (SPCC1223.14)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Stress response

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited (EC:2.5.1.54)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase
Gene namesi
Name:aro4
ORF Names:SPAP8A3.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAP8A3.07c.
PomBaseiSPAP8A3.07c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrion Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147631 – 372Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibitedAdd BLAST372

Proteomic databases

MaxQBiQ9UT09.
PRIDEiQ9UT09.

Interactioni

Protein-protein interaction databases

BioGridi279051. 100 interactors.
MINTiMINT-4709291.

Structurei

3D structure databases

ProteinModelPortaliQ9UT09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000220501.
InParanoidiQ9UT09.
KOiK01626.
OMAiSWETTDA.
OrthoDBiEOG092C2RSR.
PhylomeDBiQ9UT09.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UT09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPVFLPSGE TYDQEHLDDN RVLGYNPLVP AALVQQEIPV SETSRKVITD
60 70 80 90 100
SRKEIQAILN KQDDRIIVVV GPCSIHDPKL AMDYAKLLKP KADELQDALC
110 120 130 140 150
VVMRCYLEKP RTTIGWKGLV NDPNLDGSFA INKGIRMARQ MYCDVTNFGI
160 170 180 190 200
PLASEMLDNI SPQFFADLLS FGAIGARTTE SQLHRELASA LSFPVGFKNG
210 220 230 240 250
TDGTVGVAID AIGATAHPHT MLGVTKQGLA AITMTRGNKD TFIILRGGKK
260 270 280 290 300
GPNYDAEHVA AVRKDLEKAN LPPRIMIDCS HGNSSKNHLN QPKVSKSIAE
310 320 330 340 350
QIRNGDSSIV GVMIESHINE GRQDAPIRPG VKDTLKYGVS ITDACVSWEQ
360 370
TAPMLDDLAE AVRARRQNQK SN
Length:372
Mass (Da):40,638
Last modified:May 1, 2000 - v1
Checksum:i0A14A740F8572A1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB55174.1.
PIRiT39244.
RefSeqiNP_594946.1. NM_001020377.2.

Genome annotation databases

EnsemblFungiiSPAP8A3.07c.1; SPAP8A3.07c.1:pep; SPAP8A3.07c.
GeneIDi2542597.
KEGGispo:SPAP8A3.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB55174.1.
PIRiT39244.
RefSeqiNP_594946.1. NM_001020377.2.

3D structure databases

ProteinModelPortaliQ9UT09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279051. 100 interactors.
MINTiMINT-4709291.

Proteomic databases

MaxQBiQ9UT09.
PRIDEiQ9UT09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAP8A3.07c.1; SPAP8A3.07c.1:pep; SPAP8A3.07c.
GeneIDi2542597.
KEGGispo:SPAP8A3.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAP8A3.07c.
PomBaseiSPAP8A3.07c.

Phylogenomic databases

HOGENOMiHOG000220501.
InParanoidiQ9UT09.
KOiK01626.
OMAiSWETTDA.
OrthoDBiEOG092C2RSR.
PhylomeDBiQ9UT09.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084.

Miscellaneous databases

PROiQ9UT09.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAROG_SCHPO
AccessioniPrimary (citable) accession number: Q9UT09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.