Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9UT09 (AROG_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
EC=2.5.1.54
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase
Gene names
Name:aro4
ORF Names:SPAP8A3.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity.

Catalytic activity

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

Belongs to the class-I DAHP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
PRO_0000314763

Sequences

Sequence LengthMass (Da)Tools
Q9UT09 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0A14A740F8572A1D

FASTA37240,638
        10         20         30         40         50         60 
MSPVFLPSGE TYDQEHLDDN RVLGYNPLVP AALVQQEIPV SETSRKVITD SRKEIQAILN 

        70         80         90        100        110        120 
KQDDRIIVVV GPCSIHDPKL AMDYAKLLKP KADELQDALC VVMRCYLEKP RTTIGWKGLV 

       130        140        150        160        170        180 
NDPNLDGSFA INKGIRMARQ MYCDVTNFGI PLASEMLDNI SPQFFADLLS FGAIGARTTE 

       190        200        210        220        230        240 
SQLHRELASA LSFPVGFKNG TDGTVGVAID AIGATAHPHT MLGVTKQGLA AITMTRGNKD 

       250        260        270        280        290        300 
TFIILRGGKK GPNYDAEHVA AVRKDLEKAN LPPRIMIDCS HGNSSKNHLN QPKVSKSIAE 

       310        320        330        340        350        360 
QIRNGDSSIV GVMIESHINE GRQDAPIRPG VKDTLKYGVS ITDACVSWEQ TAPMLDDLAE 

       370 
AVRARRQNQK SN

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAB55174.1.
PIRT39244.
RefSeqNP_594946.1. NM_001020377.1.

3D structure databases

HSSPHSSP built from PDB template 1OFP based on UniProtKB P32449.
ProteinModelPortalQ9UT09.
SMRQ9UT09. Positions 21-370.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9UT09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAP8A3.07c.1; SPAP8A3.07c.1:pep; SPAP8A3.07c.
GeneID2542597.
GenomeReviewsGene locus aro4 in contig CU329670_GR.
KEGGspo:SPAP8A3.07c.
NMPDRfig|4896.1.peg.4916.

Organism-specific databases

GeneDB_SpombeSPAP8A3.07c.

Phylogenomic databases

eggNOGfuNOG04423.
GeneTreeEFGT00050000003783.
HOGENOMHBG670536.
OMAITTTKGN.
OrthoDBEOG4ZGSMV.

Gene expression databases

ArrayExpressQ9UT09.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01626.
PANTHERPTHR21225. AroFGH. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsTIGR00034. AroFGH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROG_SCHPO
AccessionPrimary (citable) accession number: Q9UT09
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents