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Q9USZ0 (WDR6_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized WD repeat-containing protein C1306.02
Gene names
ORF Names:SPBC1306.02, SPBC4.08
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a role in the regulation of the retromer complex and in the recycling from endosomes of plasma membrane proteins. May be involved in the methylation of the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)) by SPAC4F10.03c By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

Belongs to the WD repeat WDR6 family.

Contains 15 WD repeats.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytic recycling

Inferred from sequence orthology. Source: PomBase

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytosol

Inferred from direct assay Ref.2. Source: PomBase

endosome

Inferred from sequence orthology. Source: PomBase

nucleus

Inferred from direct assay Ref.2. Source: PomBase

protein complex

Non-traceable author statement. Source: PomBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 984984Uncharacterized WD repeat-containing protein C1306.02
PRO_0000316567

Regions

Repeat14 – 5239WD 1
Repeat142 – 18342WD 2
Repeat192 – 23140WD 3
Repeat235 – 27541WD 4
Repeat278 – 31841WD 5
Repeat326 – 36439WD 6
Repeat366 – 40742WD 7
Repeat461 – 50242WD 8
Repeat507 – 54943WD 9
Repeat650 – 68940WD 10
Repeat695 – 73339WD 11
Repeat752 – 79746WD 12
Repeat806 – 84540WD 13
Repeat854 – 89946WD 14
Repeat910 – 94940WD 15

Sequences

Sequence LengthMass (Da)Tools
Q9USZ0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: FA9854A13B1E82A6

FASTA984110,977
        10         20         30         40         50         60 
MLVEGDKGVL EPVNFVGPVT SLALIHNDKF LCCAQGPCLR IYDVSESRHE SDLIKSILLP 

        70         80         90        100        110        120 
FHNRIHGMLP CKQGLFVWGG TYFAVVDVET SQVYYDRISD WIFNAAELGE ENKFCVVTSK 

       130        140        150        160        170        180 
NQVHLLSLSK GSWEVTNTIS CEKTPLLFCA TVQISGNEIY IASASAFQQI YVWKFNYNNP 

       190        200        210        220        230        240 
PSCVSIDTYL VGHEGACFDL KFSSDGRYLC SVSEDRTLRL WSIESSPFLI ATGFGHSARV 

       250        260        270        280        290        300 
WRCVFLPNKE IATVSEDLTL RLWTWNDKTL TNTYTYTGHR GKHIWSLVVS SANPIIYTGG 

       310        320        330        340        350        360 
NDGSVRSWDY KTRIQESCIS VSSLFTSKTL LASFCFVKCQ KLLCLAKNGE MSIIDNKGKK 

       370        380        390        400        410        420 
AIPALTTTSD MSIIRSWKNS FFVAAASNKG TIYVFSYQNT NLLKAIDLHR GKIQQLLTYQ 

       430        440        450        460        470        480 
VKERYFLLSK SFVGKNQFRV YLQEFDFEAD KVNLISTIEL ELPATFDPTS LTVDEEYSNF 

       490        500        510        520        530        540 
LIGSRTGSLA LYNIGESNYL SVWRRIHEFD AISSIHIKSS KRDYLLIQTV GRDGYVNLFS 

       550        560        570        580        590        600 
IPRVEKSAVP QELCSKKCCD GILSGGLCKK LKNGKENQWV WGFHASNFFL RDETNETNVF 

       610        620        630        640        650        660 
FIDCGGSHRP WAFSMEMDIQ SFASYRANQL YIYSTALNLL QRNSVLQNGL HGREIRAMDF 

       670        680        690        700        710        720 
NPSGDLLLSG SEDTKVTLLE FQSNGNIIPL NSVKFHNSGI QSLTWFSDDI LFSTGGLEEL 

       730        740        750        760        770        780 
NVYRLIQKPE AYLKRIVHEK LCKPNKSNKT YDGDLRITDI SVVKATHLGE RVLWINTVQS 

       790        800        810        820        830        840 
DSTIKAFTYN VDTKQLNCIK SWKYKTVCLV FAEAVIFGSH LLLVVASTDG NVAIWNTFWR 

       850        860        870        880        890        900 
DPQIEPLIIW IKTVHQFCVK SLNISRDQDV LTISTGGDDG AISRSILLLE QISENSVVVN 

       910        920        930        940        950        960 
SLHNYFFAEA HASSVTGVLS ITKELLLSVS IDQRILLWKV EGDSLKPILE RYTHVADVGG 

       970        980 
MIRNNDFLII YGIGCEVFRL GSLR

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAB62092.1.
PIRT50309.
RefSeqNP_595473.1. NM_001021384.2.

3D structure databases

ProteinModelPortalQ9USZ0.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPBC1306.02-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1306.02.1; SPBC1306.02.1:pep; SPBC1306.02.
GeneID2539918.
KEGGspo:SPBC1306.02.

Organism-specific databases

PomBaseSPBC1306.02.

Phylogenomic databases

eggNOGCOG2319.
OMACGGGHRC.
OrthoDBEOG4PK5H3.

Family and domain databases

Gene3D2.130.10.10. 4 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 4 hits.
[Graphical view]
SMARTSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 3 hits.
PROSITEPS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801061.

Entry information

Entry nameWDR6_SCHPO
AccessionPrimary (citable) accession number: Q9USZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents