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Q9USY4 (ABP2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ARS-binding protein 2
Gene names
Name:abp2
ORF Names:SPBC1861.02
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds, preferentially, to the Maundrell ARS consensus sequence within ARS3002. Ref.1

Subcellular location

Nucleus Ref.1.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processDNA-dependent DNA replication initiation

Inferred by curator. Source: GeneDB_Spombe

   Cellular componentnuclear replication fork

Inferred by curator. Source: GeneDB_Spombe

spindle pole body

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionDNA replication origin binding

Inferred from direct assay. Source: GeneDB_Spombe

protein binding

Inferred from physical interaction. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527ARS-binding protein 2
PRO_0000064430

Amino acid modifications

Modified residue2971Phosphoserine Ref.3
Modified residue2981Phosphoserine Ref.3
Modified residue3021Phosphoserine Ref.3

Experimental info

Mutagenesis3311R → A: 40-fold decrease in DNA-binding. Ref.1
Mutagenesis3321G → A: Loss of DNA-binding. Ref.1
Mutagenesis3331R → A: Loss of DNA-binding. Ref.1
Sequence conflict2601A → P in AAC49930. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9USY4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 2860AE683999B9F4

FASTA52759,629
        10         20         30         40         50         60 
MNFYSLLPSR HDVSADNITE KFCQFCLCCN PWYAGADTRQ LANAFNMIPK SEGQKFEIWV 

        70         80         90        100        110        120 
LFLLVRQYHQ KIINSWSKLV GFLGVERKDE QSTQKIQQYV VRLKRWMSQT HVDAFFDYLL 

       130        140        150        160        170        180 
NKPNPYYLEI PETQPQVRCN VNVTDDLVIK SLRAGLMSHP DVNSSSISTM RTSTSPSNWI 

       190        200        210        220        230        240 
HSASASLDDN THNLGSFVTN PHADSQECPT PQSLLMRASH HMSERGSQQA HQTTPQNHSL 

       250        260        270        280        290        300 
PHPPNMFEPP DEDHQLPSAA NNSHNHDHAF QTAEAVGVAD SIDPDWHQWP DDLRDVSSPK 

       310        320        330        340        350        360 
ESDGLNDSWS RQTNQVETEN VENEAGVPRK RGRPPGARNK IKRLRSEPSV SLTLSISWYE 

       370        380        390        400        410        420 
RFEKLMHAQN TMLRSAFSHV ARLPMETVSQ LLSHYTETIS QYLPPSETSP IPKTPNFKFI 

       430        440        450        460        470        480 
SSTLLALVSS HSEILEASTD RLIWTVHQGP LTATICHAFN LEKAPSMHSL AEAQMIPDVP 

       490        500        510        520 
ISHSNSMEPL DTVSSLKLEI AKLNAALKEK NLELENLKRK IMNAVFD

« Hide

References

« Hide 'large scale' references
[1]"Isolation, characterization, and molecular cloning of a protein (Abp2) that binds to a Schizosaccharomyces pombe origin of replication (ars3002)."
Sanchez J.P., Murakami Y., Huberman J.A., Hurwitz J.
Mol. Cell. Biol. 18:1670-1681(1998) [PubMed: 9488484] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 154-171; 302-308; 312-328; 377-384 AND 419-431, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-331; GLY-332 AND ARG-333.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297; SER-298 AND SER-302, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U73044 mRNA. Translation: AAC49930.1.
CU329671 Genomic DNA. Translation: CAB52738.1.
PIRT39741.
RefSeqNP_596719.1. NM_001022644.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9USY4. 1 interaction.
STRINGQ9USY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1861.02.1; SPBC1861.02.1:pep; SPBC1861.02.
GeneID2539827.
GenomeReviewsGene locus abp2 in contig CU329671_GR.
KEGGspo:SPBC1861.02.
NMPDRfig|4896.1.peg.2585.

Organism-specific databases

GeneDB_SpombeSPBC1861.02.

Phylogenomic databases

eggNOGfuNOG10178.
GeneTreeEFGT00050000002621.
OrthoDBEOG4NS6KP.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004704-MONOMER.

Gene expression databases

ArrayExpressQ9USY4.

Family and domain databases

InterProIPR018562. ARS_binding_2.
[Graphical view]
PfamPF09441. Abp2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameABP2_SCHPO
AccessionPrimary (citable) accession number: Q9USY4
Secondary accession number(s): P78967
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: November 16, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents