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Protein

Beta-1,3-galactosyltransferase pvg3

Gene

pvg3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell wall biogenesis. Has a role in the addition of Gal-beta1,3 moeities to galactomannans and their subsequent pyruvylation. Has a role in meiosis.2 Publications

Catalytic activityi

UDP-alpha-D-galactose + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein] = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-[protein].

GO - Molecular functioni

  • galactosylxylosylprotein 3-beta-galactosyltransferase activity Source: UniProtKB-EC
  • pyruvyltransferase activity Source: PomBase

GO - Biological processi

  • 4,6-pyruvylated galactose residue biosynthetic process Source: PomBase
  • cell wall organization Source: UniProtKB-KW
  • meiotic cell cycle Source: UniProtKB-KW
  • protein glycosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation, Meiosis

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase pvg3 (EC:2.4.1.134)
Alternative name(s):
Meiotically up-regulated gene 49 protein
Pyruvylated Gal-beta-1,3-epitope synthesis protein 3
Short name:
PvGal synthesis protein 3
Gene namesi
Name:pvg3
Synonyms:mug49
ORF Names:SPBC1921.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1921.06c.
PomBaseiSPBC1921.06c. pvg3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini30 – 378349LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: PomBase
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Beta-1,3-galactosyltransferase pvg3PRO_0000076296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis
Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9USX0.

Interactioni

Protein-protein interaction databases

BioGridi277345. 2 interactions.
MINTiMINT-4708996.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9USX0.
OrthoDBiEOG7BKD41.
PhylomeDBiQ9USX0.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9USX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSNSKKKIF LYVLIAGVAT FSFAFLVLNR LQAEEHSLAY VENLFLDPFI
60 70 80 90 100
KQNESLAHAN DRPFKLYLGI FSQAKNVDRR NFLRTDYNEY IKEFAVNDTV
110 120 130 140 150
DVRFILGLPE NEQELATIRE EQRTYGDLAV LPIPENVDAG KSIVYFQTFL
160 170 180 190 200
EGYQPFPLFS ELADNLIMPS TQFHGSFIYN QSIKTYELPG MKEFQDLGEP
210 220 230 240 250
KHDYDFIVKA DDDSFLNLPR LFEMLKEHVG KSRFYFGRDC TRRELPTAVR
260 270 280 290 300
DFPYMCGFFY IVSPDMAYEV AKRRNIIIPF EDAQTGYSIY LSGNVKNAEF
310 320 330 340 350
SKCTLYDLIL PNEGFNYRQS YLRIDAIAVH KLKSIPLLST VSNWFKKMYE
360 370
HRANCSALIE TERLSCLQAT IPLPSLDV
Length:378
Mass (Da):43,834
Last modified:May 1, 2000 - v1
Checksum:i9E621E5866407CA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB58972.1.
PIRiT39790.
RefSeqiNP_595999.1. NM_001021907.2.

Genome annotation databases

EnsemblFungiiSPBC1921.06c.1; SPBC1921.06c.1:pep; SPBC1921.06c.
GeneIDi2540827.
KEGGispo:SPBC1921.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB58972.1.
PIRiT39790.
RefSeqiNP_595999.1. NM_001021907.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277345. 2 interactions.
MINTiMINT-4708996.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

MaxQBiQ9USX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1921.06c.1; SPBC1921.06c.1:pep; SPBC1921.06c.
GeneIDi2540827.
KEGGispo:SPBC1921.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1921.06c.
PomBaseiSPBC1921.06c. pvg3.

Phylogenomic databases

InParanoidiQ9USX0.
OrthoDBiEOG7BKD41.
PhylomeDBiQ9USX0.

Miscellaneous databases

NextBioi20801944.
PROiQ9USX0.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Five genes involved in biosynthesis of the pyruvylated Galbeta1,3-epitope in Schizosaccharomyces pombe N-linked glycans."
    Andreishcheva E.N., Kunkel J.P., Gemmill T.R., Trimble R.B.
    J. Biol. Chem. 279:35644-35655(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events."
    Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L., Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P., Smith G.R., Moreno S.
    Curr. Biol. 15:2056-2062(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MEIOSIS.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPVG3_SCHPO
AccessioniPrimary (citable) accession number: Q9USX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2000
Last modified: April 13, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.