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Q9USU8

- NGG1_SCHPO

UniProt

Q9USU8 - NGG1_SCHPO

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Protein

Chromatin-remodeling complexes subunit ngg1

Gene
ngg1, ada3, kap1, SPBC28F2.10c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription regulator. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of a subset of genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.

GO - Biological processi

  1. chromatin remodeling Source: PomBase
  2. histone acetylation Source: PomBase
  3. regulation of transcription from RNA polymerase II promoter Source: PomBase
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin-remodeling complexes subunit ngg1
Alternative name(s):
Kinesin-associated protein 1
Gene namesi
Name:ngg1
Synonyms:ada3, kap1
ORF Names:SPBC28F2.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC28F2.10c.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nuclear chromatin Source: PomBase
  2. nucleus Source: PomBase
  3. SAGA complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Chromatin-remodeling complexes subunit ngg1PRO_0000353803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201Phosphoserine1 Publication
Modified residuei144 – 1441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9USU8.

Interactioni

Subunit structurei

Component of the SAGA complex, the SALSA complex, the ADA complex and the SLIK complex which is probably a subcomplex of SAGA.

Protein-protein interaction databases

BioGridi276964. 331 interactions.
IntActiQ9USU8. 2 interactions.
MINTiMINT-8210494.
STRINGi4896.SPBC28F2.10c-1.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili417 – 47660 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the NGG1 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG265778.
KOiK11315.
OrthoDBiEOG7N63WV.
PhylomeDBiQ9USU8.

Family and domain databases

InterProiIPR019340. Histone_AcTrfase_su3.
[Graphical view]
PfamiPF10198. Ada3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USU8-1 [UniParc]FASTAAdd to Basket

« Hide

MSSEQQNEAD SKPAVIPQCF KIENQYETFS RLSETSTPGV VPSVSTLWRL    50
LFELQKMIEC EPSCVEYFRQ RKEELESHVD SEIETSKDES SVNKVEEKVE 100
EFKEDNVEQE IKQKRSLSES PQESMLEKVS KKPKVSEAHN EEISPENVET 150
IENELDLPVK GKDEQTTGLV YKNANDLLTG SLLSFIVDDS FSYEQKKKLL 200
CVDSFPTSDV RSLVAGTPAT DDFSHNKPNN QISISTFYSS LDPYFRAFND 250
DDIAFLKKGF DVSSSYNIPP LGERYYDLTP EDEMTNLCAN SIYQNLQTSA 300
QGSLEAFNEA DTVSEEVRCG PLTERLMASL IPCYTQNDEE QKPSIAVGEF 350
AETDSGSEKS KIGTSIDGIE SGNNEYTEQP DIQESSLSIC EDRLRYTLKQ 400
LGILYDGDVD WSKRQDDEIS ATLRSLNARL KVVSDENEKM RNALLQMLPE 450
EMAFQEFQNV MDDLDKQIEQ AYVKRNRSLK VKKKRIVTDK IGSSATSGSF 500
PVIKSLMDKR SMWLEKLQPL FQDKLTQHLG SPTSIFNDLS DHTTSNYSTS 550
V 551
Length:551
Mass (Da):62,407
Last modified:May 1, 2000 - v1
Checksum:iF037D741B0A78403
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF351206 mRNA. Translation: AAK17897.1.
CU329671 Genomic DNA. Translation: CAB57939.1.
PIRiT40053.
RefSeqiNP_595671.1. NM_001021566.2.

Genome annotation databases

EnsemblFungiiSPBC28F2.10c.1; SPBC28F2.10c.1:pep; SPBC28F2.10c.
GeneIDi2540436.
KEGGispo:SPBC28F2.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF351206 mRNA. Translation: AAK17897.1 .
CU329671 Genomic DNA. Translation: CAB57939.1 .
PIRi T40053.
RefSeqi NP_595671.1. NM_001021566.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276964. 331 interactions.
IntActi Q9USU8. 2 interactions.
MINTi MINT-8210494.
STRINGi 4896.SPBC28F2.10c-1.

Proteomic databases

MaxQBi Q9USU8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC28F2.10c.1 ; SPBC28F2.10c.1:pep ; SPBC28F2.10c .
GeneIDi 2540436.
KEGGi spo:SPBC28F2.10c.

Organism-specific databases

PomBasei SPBC28F2.10c.

Phylogenomic databases

eggNOGi NOG265778.
KOi K11315.
OrthoDBi EOG7N63WV.
PhylomeDBi Q9USU8.

Miscellaneous databases

NextBioi 20801563.
PROi Q9USU8.

Family and domain databases

InterProi IPR019340. Histone_AcTrfase_su3.
[Graphical view ]
Pfami PF10198. Ada3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The studies of the kinesin-associated proteins in Schizosaccharomyces pombe."
    Jeong J.W., Kim H.B.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-144, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiNGG1_SCHPO
AccessioniPrimary (citable) accession number: Q9USU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3