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Q9USU8 (NGG1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chromatin-remodeling complexes subunit ngg1
Alternative name(s):
Kinesin-associated protein 1
Gene names
Name:ngg1
Synonyms:ada3, kap1
ORF Names:SPBC28F2.10c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription regulator. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of a subset of genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.

Subunit structure

Component of the SAGA complex, the SALSA complex, the ADA complex and the SLIK complex which is probably a subcomplex of SAGA.

Subcellular location

Nucleus Ref.3.

Sequence similarities

Belongs to the NGG1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Chromatin-remodeling complexes subunit ngg1
PRO_0000353803

Regions

Coiled coil417 – 47660 Potential

Amino acid modifications

Modified residue1201Phosphoserine Ref.4
Modified residue1441Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9USU8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F037D741B0A78403

FASTA55162,407
        10         20         30         40         50         60 
MSSEQQNEAD SKPAVIPQCF KIENQYETFS RLSETSTPGV VPSVSTLWRL LFELQKMIEC 

        70         80         90        100        110        120 
EPSCVEYFRQ RKEELESHVD SEIETSKDES SVNKVEEKVE EFKEDNVEQE IKQKRSLSES 

       130        140        150        160        170        180 
PQESMLEKVS KKPKVSEAHN EEISPENVET IENELDLPVK GKDEQTTGLV YKNANDLLTG 

       190        200        210        220        230        240 
SLLSFIVDDS FSYEQKKKLL CVDSFPTSDV RSLVAGTPAT DDFSHNKPNN QISISTFYSS 

       250        260        270        280        290        300 
LDPYFRAFND DDIAFLKKGF DVSSSYNIPP LGERYYDLTP EDEMTNLCAN SIYQNLQTSA 

       310        320        330        340        350        360 
QGSLEAFNEA DTVSEEVRCG PLTERLMASL IPCYTQNDEE QKPSIAVGEF AETDSGSEKS 

       370        380        390        400        410        420 
KIGTSIDGIE SGNNEYTEQP DIQESSLSIC EDRLRYTLKQ LGILYDGDVD WSKRQDDEIS 

       430        440        450        460        470        480 
ATLRSLNARL KVVSDENEKM RNALLQMLPE EMAFQEFQNV MDDLDKQIEQ AYVKRNRSLK 

       490        500        510        520        530        540 
VKKKRIVTDK IGSSATSGSF PVIKSLMDKR SMWLEKLQPL FQDKLTQHLG SPTSIFNDLS 

       550 
DHTTSNYSTS V 

« Hide

References

« Hide 'large scale' references
[1]"The studies of the kinesin-associated proteins in Schizosaccharomyces pombe."
Jeong J.W., Kim H.B.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-144, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF351206 mRNA. Translation: AAK17897.1.
CU329671 Genomic DNA. Translation: CAB57939.1.
PIRT40053.
RefSeqNP_595671.1. NM_001021566.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276964. 331 interactions.
IntActQ9USU8. 2 interactions.
MINTMINT-8210494.
STRING4896.SPBC28F2.10c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC28F2.10c.1; SPBC28F2.10c.1:pep; SPBC28F2.10c.
GeneID2540436.
KEGGspo:SPBC28F2.10c.

Organism-specific databases

PomBaseSPBC28F2.10c.

Phylogenomic databases

eggNOGNOG265778.
KOK11315.
OrthoDBEOG7N63WV.
PhylomeDBQ9USU8.

Family and domain databases

InterProIPR019340. Histone_AcTrfase_su3.
[Graphical view]
PfamPF10198. Ada3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801563.
PROQ9USU8.

Entry information

Entry nameNGG1_SCHPO
AccessionPrimary (citable) accession number: Q9USU8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names