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Protein

Chromatin-remodeling complexes subunit ngg1

Gene

ngg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription regulator. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of a subset of genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin-remodeling complexes subunit ngg1
Alternative name(s):
Kinesin-associated protein 1
Gene namesi
Name:ngg1
Synonyms:ada3, kap1
ORF Names:SPBC28F2.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC28F2.10c
PomBaseiSPBC28F2.10c ngg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003538031 – 551Chromatin-remodeling complexes subunit ngg1Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120Phosphoserine1 Publication1
Modified residuei144Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9USU8
PaxDbiQ9USU8
PRIDEiQ9USU8

PTM databases

iPTMnetiQ9USU8

Interactioni

Subunit structurei

Component of the SAGA complex, the SALSA complex, the ADA complex and the SLIK complex which is probably a subcomplex of SAGA.

Protein-protein interaction databases

BioGridi276964, 335 interactors
IntActiQ9USU8, 2 interactors
MINTiQ9USU8
STRINGi4896.SPBC28F2.10c.1

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili417 – 476Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the NGG1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ9USU8
KOiK11315
OrthoDBiEOG092C1FFK
PhylomeDBiQ9USU8

Family and domain databases

InterProiView protein in InterPro
IPR019340 Histone_AcTrfase_su3
PANTHERiPTHR13556 PTHR13556, 1 hit
PfamiView protein in Pfam
PF10198 Ada3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9USU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEQQNEAD SKPAVIPQCF KIENQYETFS RLSETSTPGV VPSVSTLWRL
60 70 80 90 100
LFELQKMIEC EPSCVEYFRQ RKEELESHVD SEIETSKDES SVNKVEEKVE
110 120 130 140 150
EFKEDNVEQE IKQKRSLSES PQESMLEKVS KKPKVSEAHN EEISPENVET
160 170 180 190 200
IENELDLPVK GKDEQTTGLV YKNANDLLTG SLLSFIVDDS FSYEQKKKLL
210 220 230 240 250
CVDSFPTSDV RSLVAGTPAT DDFSHNKPNN QISISTFYSS LDPYFRAFND
260 270 280 290 300
DDIAFLKKGF DVSSSYNIPP LGERYYDLTP EDEMTNLCAN SIYQNLQTSA
310 320 330 340 350
QGSLEAFNEA DTVSEEVRCG PLTERLMASL IPCYTQNDEE QKPSIAVGEF
360 370 380 390 400
AETDSGSEKS KIGTSIDGIE SGNNEYTEQP DIQESSLSIC EDRLRYTLKQ
410 420 430 440 450
LGILYDGDVD WSKRQDDEIS ATLRSLNARL KVVSDENEKM RNALLQMLPE
460 470 480 490 500
EMAFQEFQNV MDDLDKQIEQ AYVKRNRSLK VKKKRIVTDK IGSSATSGSF
510 520 530 540 550
PVIKSLMDKR SMWLEKLQPL FQDKLTQHLG SPTSIFNDLS DHTTSNYSTS

V
Length:551
Mass (Da):62,407
Last modified:May 1, 2000 - v1
Checksum:iF037D741B0A78403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351206 mRNA Translation: AAK17897.1
CU329671 Genomic DNA Translation: CAB57939.1
PIRiT40053
RefSeqiNP_595671.1, NM_001021566.2

Genome annotation databases

EnsemblFungiiSPBC28F2.10c.1; SPBC28F2.10c.1:pep; SPBC28F2.10c
GeneIDi2540436
KEGGispo:SPBC28F2.10c

Entry informationi

Entry nameiNGG1_SCHPO
AccessioniPrimary (citable) accession number: Q9USU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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