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Q9USU8

- NGG1_SCHPO

UniProt

Q9USU8 - NGG1_SCHPO

Protein

Chromatin-remodeling complexes subunit ngg1

Gene

ngg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Transcription regulator. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of a subset of genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.

    GO - Biological processi

    1. chromatin remodeling Source: PomBase
    2. histone acetylation Source: PomBase
    3. regulation of transcription from RNA polymerase II promoter Source: PomBase
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromatin-remodeling complexes subunit ngg1
    Alternative name(s):
    Kinesin-associated protein 1
    Gene namesi
    Name:ngg1
    Synonyms:ada3, kap1
    ORF Names:SPBC28F2.10c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC28F2.10c.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nuclear chromatin Source: PomBase
    2. nucleus Source: PomBase
    3. SAGA complex Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Chromatin-remodeling complexes subunit ngg1PRO_0000353803Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei120 – 1201Phosphoserine1 Publication
    Modified residuei144 – 1441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9USU8.

    Interactioni

    Subunit structurei

    Component of the SAGA complex, the SALSA complex, the ADA complex and the SLIK complex which is probably a subcomplex of SAGA.

    Protein-protein interaction databases

    BioGridi276964. 331 interactions.
    IntActiQ9USU8. 2 interactions.
    MINTiMINT-8210494.
    STRINGi4896.SPBC28F2.10c-1.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili417 – 47660Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NGG1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG265778.
    KOiK11315.
    OrthoDBiEOG7N63WV.
    PhylomeDBiQ9USU8.

    Family and domain databases

    InterProiIPR019340. Histone_AcTrfase_su3.
    [Graphical view]
    PfamiPF10198. Ada3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9USU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEQQNEAD SKPAVIPQCF KIENQYETFS RLSETSTPGV VPSVSTLWRL    50
    LFELQKMIEC EPSCVEYFRQ RKEELESHVD SEIETSKDES SVNKVEEKVE 100
    EFKEDNVEQE IKQKRSLSES PQESMLEKVS KKPKVSEAHN EEISPENVET 150
    IENELDLPVK GKDEQTTGLV YKNANDLLTG SLLSFIVDDS FSYEQKKKLL 200
    CVDSFPTSDV RSLVAGTPAT DDFSHNKPNN QISISTFYSS LDPYFRAFND 250
    DDIAFLKKGF DVSSSYNIPP LGERYYDLTP EDEMTNLCAN SIYQNLQTSA 300
    QGSLEAFNEA DTVSEEVRCG PLTERLMASL IPCYTQNDEE QKPSIAVGEF 350
    AETDSGSEKS KIGTSIDGIE SGNNEYTEQP DIQESSLSIC EDRLRYTLKQ 400
    LGILYDGDVD WSKRQDDEIS ATLRSLNARL KVVSDENEKM RNALLQMLPE 450
    EMAFQEFQNV MDDLDKQIEQ AYVKRNRSLK VKKKRIVTDK IGSSATSGSF 500
    PVIKSLMDKR SMWLEKLQPL FQDKLTQHLG SPTSIFNDLS DHTTSNYSTS 550
    V 551
    Length:551
    Mass (Da):62,407
    Last modified:May 1, 2000 - v1
    Checksum:iF037D741B0A78403
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF351206 mRNA. Translation: AAK17897.1.
    CU329671 Genomic DNA. Translation: CAB57939.1.
    PIRiT40053.
    RefSeqiNP_595671.1. NM_001021566.2.

    Genome annotation databases

    EnsemblFungiiSPBC28F2.10c.1; SPBC28F2.10c.1:pep; SPBC28F2.10c.
    GeneIDi2540436.
    KEGGispo:SPBC28F2.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF351206 mRNA. Translation: AAK17897.1 .
    CU329671 Genomic DNA. Translation: CAB57939.1 .
    PIRi T40053.
    RefSeqi NP_595671.1. NM_001021566.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276964. 331 interactions.
    IntActi Q9USU8. 2 interactions.
    MINTi MINT-8210494.
    STRINGi 4896.SPBC28F2.10c-1.

    Proteomic databases

    MaxQBi Q9USU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC28F2.10c.1 ; SPBC28F2.10c.1:pep ; SPBC28F2.10c .
    GeneIDi 2540436.
    KEGGi spo:SPBC28F2.10c.

    Organism-specific databases

    PomBasei SPBC28F2.10c.

    Phylogenomic databases

    eggNOGi NOG265778.
    KOi K11315.
    OrthoDBi EOG7N63WV.
    PhylomeDBi Q9USU8.

    Miscellaneous databases

    NextBioi 20801563.
    PROi Q9USU8.

    Family and domain databases

    InterProi IPR019340. Histone_AcTrfase_su3.
    [Graphical view ]
    Pfami PF10198. Ada3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The studies of the kinesin-associated proteins in Schizosaccharomyces pombe."
      Jeong J.W., Kim H.B.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-144, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiNGG1_SCHPO
    AccessioniPrimary (citable) accession number: Q9USU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3