Q9USS6 (PPA4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable acid phosphatase SPBC4.06
EC=3.1.3.2

Gene names

ORF Names:

SPBC4.06

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate. UniProtKB Q9NPH0
Subcellular location	Mitochondrion Ref.2.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Probable acid phosphatase SPBC4.06		PRO_0000311719
Sites
	Active site	35	1	Nucleophile By similarity UniProtKB Q9NPH0
	Active site	330	1	Proton donor By similarity UniProtKB P15309

Sequences

	Sequence		Length	Mass (Da)
	Q9USS6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 113D45882EA0DFA9	FASTA	462	51,976
	10 20 30 40 50 60 MSQMSSASVK FPDSVPGVDY PKQLQLKYLQ VIFRHGERAP VKERLGSAGI PKDWKLCNNA 70 80 90 100 110 120 RRFFAQIKGE KEWSVLGFER KVESPVDTSL AAPTSDNSPS GVCIHGELTD FGRVTTRTLG 130 140 150 160 170 180 EYLRERYVKQ LKFLPDELNN YADVYMRATP MVRALESLEH VFSGLYPESK RKMGLPVIFT 190 200 210 220 230 240 RNWSDENLLP NENNCPRLVQ LYEEFAERAA KLYDPLLAGR ASEMMSQFMN GQPVRVVSSH 250 260 270 280 290 300 PRLSGLLDTI NAAIGSHVDF NPNLRDEQWL RDAETAVVEE WFGGYKVSKL MRQLGAGSLL 310 320 330 340 350 360 NDLSMRMENF VVAEKNGSPY HRLALYGAHD VTIAAILASL DAFDYRWPPF TSHLEMELFE 370 380 390 400 410 420 DTSSKSDSQN QSGDNKTTDL KLFSDESTDA SNSAIVAASN SARDMSDWYV RITYNSTPVV 430 440 450 460 MGACRGQGYK GNDTICPLSI FKDTVRALKP VEYHTMCKPV KK

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAB58405.1.
PIR	T40420.
RefSeq	NP_595479.1. NM_001021390.1.
3D structure databases
HSSP	HSSP built from PDB template 1ND5 based on UniProtKB P15309.
ProteinModelPortal	Q9USS6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9USS6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBC4.06.1; SPBC4.06.1:pep; SPBC4.06.
GeneID	2540652.
KEGG	spo:SPBC4.06.
NMPDR	fig|4896.1.peg.1345.
Organism-specific databases
GeneDB_Spombe	SPBC4.06.
Phylogenomic databases
eggNOG	fuNOG09478.
GeneTree	EFGT00050000005754.
OMA	SGCHDTT.
OrthoDB	EOG4V9Z02.
Gene expression databases
ArrayExpress	Q9USS6.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. [Graphical view]
KO	K01078.
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPA4_SCHPO

Accession

Primary (citable) accession number: Q9USS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program