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Protein

Centromere protein 3

Gene

cnp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. Binds to the central core and inner repeats of the centromere.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi333 – 34513A.T hookAdd
BLAST

GO - Molecular functioni

  • centromeric DNA binding Source: PomBase

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • protein localization to kinetochore involved in kinetochore assembly Source: PomBase
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein 3
Alternative name(s):
CENP-C homolog
Gene namesi
Name:cnp3
ORF Names:SPBC1861.01c, SPBC56F2.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1861.01c.
PomBaseiSPBC1861.01c. cnp3.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: PomBase
  • condensed chromosome, centromeric region Source: PomBase
  • condensed nuclear chromosome kinetochore Source: PomBase
  • nucleolus Source: PomBase
  • nucleoplasm Source: UniProtKB-SubCell
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Centromere protein 3PRO_0000116879Add
BLAST

Proteomic databases

MaxQBiQ9USR9.

Interactioni

Protein-protein interaction databases

BioGridi276178. 3 interactions.
IntActiQ9USR9. 1 interaction.
MINTiMINT-4708618.

Structurei

3D structure databases

ProteinModelPortaliQ9USR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 A.T hook DNA-binding domain.Curated

Phylogenomic databases

InParanoidiQ9USR9.
KOiK11497.
OMAiYYSIANE.
OrthoDBiEOG7647D5.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR028386. CENP-C/Mif2/cnp3.
IPR025974. Mif2/CENP-C_cupin.
IPR028929. Mif2/cnp3_N.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR16684. PTHR16684. 1 hit.
PfamiPF11699. CENP-C_C. 1 hit.
PF15624. Mif2_N. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9USR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNETSAIP ARQRENQFFE IGVVGRKTGF TVPRDVKKGD DGFEDMDAYF
60 70 80 90 100
LSDGSIHLDE DNGDIEQDMP PVTRLQPTSP MAVNAASDEA SHASSSDSSD
110 120 130 140 150
KNPDIPSSPL LMNSRALRAS RGSSGPLIVP IDHSAFQAED EGTADKTKVD
160 170 180 190 200
GNKLSIQPRK ANRIVDFSRI KASPDRKKFE PRRSTELPSK IPSSTPKDDN
210 220 230 240 250
VQESPAFPDE NITALQKNVA NFTSIKDSGG RDNLYIQTIS KPRRSYVQNN
260 270 280 290 300
KSEQTIKPSK QNKQKEEKKT ISQGNKPNSR DEDSELSIDV PLSMLNRSLA
310 320 330 340 350
NNSQKNKKRT PNKPLQESSI NSVKEGESNP VVKRKRGRPR KNKLEIGNSV
360 370 380 390 400
QTSEATQVKG AKKPAIRNAK KMSNEKDDSL NSQSDSASGE FIKTIARNNL
410 420 430 440 450
QEIKQVERED TLVGVRRSKR TRIAPLAFWK NERVVYELHR DENRIPALPE
460 470 480 490 500
VKQIIRVDDP SPSIRQGRKK RHAKRSGVEI KSNLEAKSND VEEYDAFYKD
510 520 530 540 550
EINCEVLSWN EQNPKASEER VVGYSLPSVN LQQISNQQLK FASLFKEEPS
560 570 580 590 600
FAAGVVEMPA GAEKPVKPSK HNIMSFCILQ GKIEVTVNAT TFRMKKDGVF
610 620 630 640
IVPRGNYYSI KNIGKEAVRL YYTHATDTLE NKRRGIGDFP NER
Length:643
Mass (Da):72,052
Last modified:March 29, 2004 - v2
Checksum:i44DAD8EE46C54A4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB54977.1.
PIRiT39740.
T40544.
RefSeqiXP_001713151.1. XM_001713099.2.

Genome annotation databases

EnsemblFungiiSPBC1861.01c.1; SPBC1861.01c.1:pep; SPBC1861.01c.
GeneIDi2539620.
KEGGispo:SPBC1861.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB54977.1.
PIRiT39740.
T40544.
RefSeqiXP_001713151.1. XM_001713099.2.

3D structure databases

ProteinModelPortaliQ9USR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276178. 3 interactions.
IntActiQ9USR9. 1 interaction.
MINTiMINT-4708618.

Proteomic databases

MaxQBiQ9USR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1861.01c.1; SPBC1861.01c.1:pep; SPBC1861.01c.
GeneIDi2539620.
KEGGispo:SPBC1861.01c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1861.01c.
PomBaseiSPBC1861.01c. cnp3.

Phylogenomic databases

InParanoidiQ9USR9.
KOiK11497.
OMAiYYSIANE.
OrthoDBiEOG7647D5.

Miscellaneous databases

NextBioi20800777.
PROiQ9USR9.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR028386. CENP-C/Mif2/cnp3.
IPR025974. Mif2/CENP-C_cupin.
IPR028929. Mif2/cnp3_N.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR16684. PTHR16684. 1 hit.
PfamiPF11699. CENP-C_C. 1 hit.
PF15624. Mif2_N. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparison of Dam tagging and chromatin immunoprecipitation as tools for the identification of the binding sites for S. pombe CENP-C."
    Holland S., Ioannou D., Haines S., Brown W.R.
    Chromosome Res. 13:73-83(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCENPC_SCHPO
AccessioniPrimary (citable) accession number: Q9USR9
Secondary accession number(s): Q9USY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: May 11, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.