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Protein

Thioredoxin-like protein 1

Gene

txl1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Has a role in cellular detoxification of alkyl hydroperoxide.2 Publications

GO - Molecular functioni

  • protein disulfide oxidoreductase activity Source: PomBase
  • thioredoxin-disulfide reductase activity Source: PomBase

GO - Biological processi

  • cell redox homeostasis Source: PomBase
  • cellular oxidant detoxification Source: GOC
  • glycerol ether metabolic process Source: InterPro
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide Source: PomBase
  • protein denaturation involved in proteasomal ubiquitin-dependent protein catabolic process Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
Thioredoxin homolog 3
Gene namesi
Name:txl1
Synonyms:trx3
ORF Names:SPBC577.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC577.08c.
PomBaseiSPBC577.08c. txl1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nuclear periphery Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Thioredoxin-like protein 1PRO_0000372631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 34Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9USR1.

Interactioni

Protein-protein interaction databases

BioGridi277543. 16 interactions.
MINTiMINT-4708542.

Structurei

3D structure databases

ProteinModelPortaliQ9USR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10481ThioredoxinPROSITE-ProRule annotationAdd
BLAST
Domaini118 – 290173PITHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PITH domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000189802.
InParanoidiQ9USR1.
OMAiMSVRVIN.
OrthoDBiEOG71CFZN.
PhylomeDBiQ9USR1.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 2 hits.
PfamiPF06201. PITH. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIEIRSYQ HWISTIPKSG YLAVDCYADW CGPCKAISPL FSQLASKYAS
60 70 80 90 100
PKFVFAKVNV DEQRQIASGL GVKAMPTFVF FENGKQIDML TGANPQALKE
110 120 130 140 150
KVALISSKAT GTGALASSSS APVKGFASLQ GCIENPQLEC LNQQDDHDLK
160 170 180 190 200
SAFNSNPSSF LESDVDEQLM IYIPFLEVVK VHSIAITPVK GETSSAPKTI
210 220 230 240 250
KLYINQPNNL SFEDAESFTP TQVIEDIVYE QDDQPTIIPL RFVKFQRVNS
260 270 280 290
LVIFIYSNVG EEETTKISRL ELFGEPVGDS SKGKLQKVEA
Length:290
Mass (Da):31,889
Last modified:May 1, 2000 - v1
Checksum:i02C661616AEC2F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ386686 Genomic DNA. Translation: ABD47124.1.
CU329671 Genomic DNA. Translation: CAB54816.1.
PIRiT40552.
RefSeqiNP_595306.1. NM_001021213.2.

Genome annotation databases

EnsemblFungiiSPBC577.08c.1; SPBC577.08c.1:pep; SPBC577.08c.
GeneIDi2541028.
KEGGispo:SPBC577.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ386686 Genomic DNA. Translation: ABD47124.1.
CU329671 Genomic DNA. Translation: CAB54816.1.
PIRiT40552.
RefSeqiNP_595306.1. NM_001021213.2.

3D structure databases

ProteinModelPortaliQ9USR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277543. 16 interactions.
MINTiMINT-4708542.

Proteomic databases

MaxQBiQ9USR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC577.08c.1; SPBC577.08c.1:pep; SPBC577.08c.
GeneIDi2541028.
KEGGispo:SPBC577.08c.

Organism-specific databases

EuPathDBiFungiDB:SPBC577.08c.
PomBaseiSPBC577.08c. txl1.

Phylogenomic databases

HOGENOMiHOG000189802.
InParanoidiQ9USR1.
OMAiMSVRVIN.
OrthoDBiEOG71CFZN.
PhylomeDBiQ9USR1.

Miscellaneous databases

PROiQ9USR1.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 2 hits.
PfamiPF06201. PITH. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cellular functions and transcriptional regulation of a third thioredoxin from Schizosaccharomyces pombe."
    Kim S.-J., Jung E.-M., Jung H.-J., Song Y.S., Park E.-H., Lim C.-J.
    Can. J. Microbiol. 53:775-783(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. "The txl1+ gene from Schizosaccharomyces pombe encodes a new thioredoxin-like 1 protein that participates in the antioxidant defence against tert-butyl hydroperoxide."
    Jimenez A., Mateos L., Pedrajas J.R., Miranda-Vizuete A., Revuelta J.L.
    Yeast 24:481-490(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTXL1_SCHPO
AccessioniPrimary (citable) accession number: Q9USR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.