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Protein

Probable proteasome subunit beta type-7

Gene

SPBC577.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.987

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-7 (EC:3.4.25.1)
Gene namesi
ORF Names:SPBC577.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC577.10
PomBaseiSPBC577.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480721 – 262Probable proteasome subunit beta type-7Add BLAST262

Proteomic databases

MaxQBiQ9USQ9
PaxDbiQ9USQ9
PRIDEiQ9USQ9

PTM databases

iPTMnetiQ9USQ9

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi277392, 2 interactors
STRINGi4896.SPBC577.10.1

Structurei

3D structure databases

ProteinModelPortaliQ9USQ9
SMRiQ9USQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000181719
InParanoidiQ9USQ9
KOiK02736
OMAiKECMKVL
OrthoDBiEOG092C410Y
PhylomeDBiQ9USQ9

Family and domain databases

CDDicd03760 proteasome_beta_type_4, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR016050 Proteasome_bsu_CS
IPR016295 Proteasome_endopept_cplx_B
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF5 PTHR11599:SF5, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF001213 Psome_endopept_beta, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9USQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLELTEVW GKPQKDIFFP SGSEVEESTD APIQRTVQPI VTGSSVLALK
60 70 80 90 100
FADGVMIAAD NLASYGSLAR FYDVERLTKV GDNTIVGAGG DISDYQQIQR
110 120 130 140 150
LLEKLEIKEG NYGDGYALQP SYIHEYLSKV LYARRNKLDP YWNQLIVAGV
160 170 180 190 200
DGENKEPYVA FADLRGTTYS APAIATGFAM HLALPMLRKA TDDDRWKTLS
210 220 230 240 250
KESARATIDE CMRVLFYRDA RSLNKFSVAT ITPEGIEFQT DQSVSSKWAF
260
AEKQYGYGTQ TV
Length:262
Mass (Da):29,220
Last modified:May 1, 2000 - v1
Checksum:iCD8715FE96467AC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB54818.1
PIRiT40554
RefSeqiNP_595308.1, NM_001021215.2

Genome annotation databases

EnsemblFungiiSPBC577.10.1; SPBC577.10.1:pep; SPBC577.10
GeneIDi2540875
KEGGispo:SPBC577.10

Similar proteinsi

Entry informationi

Entry nameiPSB7_SCHPO
AccessioniPrimary (citable) accession number: Q9USQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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