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Q9USP2

- YND1_SCHPO

UniProt

Q9USP2 - YND1_SCHPO

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Protein

Golgi apyrase

Gene

ynd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Required for Golgi glycosylation and cell wall integrity. Involved in N-mannosylation of proteins in Golgi.By similarity1 Publication

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.1 Publication

Cofactori

Divalent metal cations. Ca2+, Mg2+ or Mn2+.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451Proton acceptorBy similarity

GO - Molecular functioni

  1. adenosine-diphosphatase activity Source: PomBase
  2. ATPase activity Source: PomBase
  3. ATP binding Source: UniProtKB-KW
  4. cytidine diphosphatase activity Source: PomBase
  5. GTPase activity Source: PomBase
  6. guanosine-diphosphatase activity Source: PomBase
  7. nucleoside-triphosphate diphosphatase activity Source: PomBase
  8. uridine-diphosphatase activity Source: PomBase

GO - Biological processi

  1. ADP catabolic process Source: PomBase
  2. ATP catabolic process Source: PomBase
  3. CDP catabolic process Source: PomBase
  4. GDP catabolic process Source: PomBase
  5. GTP catabolic process Source: PomBase
  6. protein glycosylation Source: UniProtKB-UniPathway
  7. UDP catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apyrase1 Publication (EC:3.6.1.5)
Alternative name(s):
ATP-diphosphataseBy similarity
ATP-diphosphohydrolaseBy similarity
Adenosine diphosphataseBy similarity
Short name:
ADPaseBy similarity
Golgi nucleoside diphosphataseBy similarity
Gene namesi
Name:ynd1Imported
ORF Names:SPCC11E10.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC11E10.05c.

Subcellular locationi

Golgi apparatus 2 Publications. Membrane Sequence Analysis; Single-pass membrane protein Sequence Analysis

GO - Cellular componenti

  1. Golgi apparatus Source: PomBase
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Golgi apyrasePRO_0000347282Add
BLAST

Proteomic databases

MaxQBiQ9USP2.

Interactioni

Protein-protein interaction databases

BioGridi275324. 11 interactions.
MINTiMINT-4708352.
STRINGi4896.SPCC11E10.05c-1.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 470470LumenalBy similaritySequence AnalysisAdd
BLAST
Topological domaini492 – 57281CytoplasmicBy similaritySequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei471 – 49121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
HOGENOMiHOG000246725.
InParanoidiQ9USP2.
OMAiLVCAKEH.
OrthoDBiEOG7QK0PD.
PhylomeDBiQ9USP2.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRKYGIFID AGSSGSRLLI YSWDYDTDSS LSDKVKKLPL IETGIGDGGK
60 70 80 90 100
WSLKVQPGIS SFANNPKHVG KKHLKELLDF AAHAIPKDVH KETPVFLSAT
110 120 130 140 150
AGMRLLGVDA QNKILSHACR YIKKNYDFDI PNCSNSIRVI DGKAEGMYGW
160 170 180 190 200
LATNYLLKTL EEKDTSTVGF LDMGGASVQI AFELPPSQLK NYKDSISTVH
210 220 230 240 250
IGLQNGQQLE YPLFVTTWLG FGANEAYRRY LGLLIESENG KVGNTLSDPC
260 270 280 290 300
SLRGRTYDID GIEFAGTGDL KQCLKLTYNL LNKDKPCSMD PCNFDGISIP
310 320 330 340 350
PVDFANTEFV GVSEFWYTTN DVFDMGGSYH FPNFYKKVDE YCGTEWETML
360 370 380 390 400
SRLYNKELTP STDENKLEKL CFKASWALNV LHEGFDVPKS NTSSNDAKDG
410 420 430 440 450
LSVIPAYHSP FTSLEKIERT EVSWTLGQVL LYASNQQLLA KPEYANYYMD
460 470 480 490 500
PYGKLIASPS KHWMRLFPNK LFFILSFIFC LFFLFSLVLF GYDPKRRQRF
510 520 530 540 550
KKFLLRLQRR KAPYIMSANG SYEDIADFSD DLEMSSPSKW HGPPIRTTSS
560 570
HVLADRLSFT ASRERTPRSP FP
Length:572
Mass (Da):64,680
Last modified:May 1, 2000 - v1
Checksum:i8E039FBFA0D3B482
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB57847.1.
PIRiT40856.
RefSeqiNP_588201.1. NM_001023191.2.

Genome annotation databases

EnsemblFungiiSPCC11E10.05c.1; SPCC11E10.05c.1:pep; SPCC11E10.05c.
GeneIDi2538741.
KEGGispo:SPCC11E10.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB57847.1 .
PIRi T40856.
RefSeqi NP_588201.1. NM_001023191.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275324. 11 interactions.
MINTi MINT-4708352.
STRINGi 4896.SPCC11E10.05c-1.

Proteomic databases

MaxQBi Q9USP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC11E10.05c.1 ; SPCC11E10.05c.1:pep ; SPCC11E10.05c .
GeneIDi 2538741.
KEGGi spo:SPCC11E10.05c.

Organism-specific databases

PomBasei SPCC11E10.05c.

Phylogenomic databases

eggNOGi COG5371.
HOGENOMi HOG000246725.
InParanoidi Q9USP2.
OMAi LVCAKEH.
OrthoDBi EOG7QK0PD.
PhylomeDBi Q9USP2.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 20799925.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 1 hit.
[Graphical view ]
PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Nucleoside diphosphatase and glycosyltransferase activities can localize to different subcellular compartments in Schizosaccharomyces pombe."
    D'Alessio C., Trombetta E.S., Parodi A.J.
    J. Biol. Chem. 278:22379-22387(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME ACTIVITY, COFACTOR, SUBCELLULAR LOCATION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYND1_SCHPO
AccessioniPrimary (citable) accession number: Q9USP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3