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Q9USP2

- YND1_SCHPO

UniProt

Q9USP2 - YND1_SCHPO

Protein

Golgi apyrase

Gene

ynd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Required for Golgi glycosylation and cell wall integrity. Involved in N-mannosylation of proteins in Golgi.By similarity1 Publication

    Catalytic activityi

    A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.1 Publication

    Cofactori

    Divalent metal cations. Ca2+, Mg2+ or Mn2+.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei145 – 1451Proton acceptorBy similarity

    GO - Molecular functioni

    1. adenosine-diphosphatase activity Source: PomBase
    2. ATPase activity Source: PomBase
    3. ATP binding Source: UniProtKB-KW
    4. cytidine diphosphatase activity Source: PomBase
    5. GTPase activity Source: PomBase
    6. guanosine-diphosphatase activity Source: PomBase
    7. nucleoside-triphosphate diphosphatase activity Source: PomBase
    8. uridine-diphosphatase activity Source: PomBase

    GO - Biological processi

    1. ADP catabolic process Source: PomBase
    2. ATP catabolic process Source: PomBase
    3. CDP catabolic process Source: PomBase
    4. GDP catabolic process Source: PomBase
    5. GTP catabolic process Source: PomBase
    6. protein glycosylation Source: UniProtKB-UniPathway
    7. UDP catabolic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi apyrase1 Publication (EC:3.6.1.5)
    Alternative name(s):
    ATP-diphosphataseBy similarity
    ATP-diphosphohydrolaseBy similarity
    Adenosine diphosphataseBy similarity
    Short name:
    ADPaseBy similarity
    Golgi nucleoside diphosphataseBy similarity
    Gene namesi
    Name:ynd1Imported
    ORF Names:SPCC11E10.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC11E10.05c.

    Subcellular locationi

    Golgi apparatus 2 Publications. Membrane Sequence Analysis; Single-pass membrane protein Sequence Analysis

    GO - Cellular componenti

    1. Golgi apparatus Source: PomBase
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Golgi apyrasePRO_0000347282Add
    BLAST

    Proteomic databases

    MaxQBiQ9USP2.

    Interactioni

    Protein-protein interaction databases

    BioGridi275324. 11 interactions.
    MINTiMINT-4708352.
    STRINGi4896.SPCC11E10.05c-1.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 470470LumenalBy similaritySequence AnalysisAdd
    BLAST
    Topological domaini492 – 57281CytoplasmicBy similaritySequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei471 – 49121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDA1/CD39 NTPase family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5371.
    HOGENOMiHOG000246725.
    OMAiLVCAKEH.
    OrthoDBiEOG7QK0PD.
    PhylomeDBiQ9USP2.

    Family and domain databases

    InterProiIPR000407. GDA1_CD39_NTPase.
    [Graphical view]
    PANTHERiPTHR11782. PTHR11782. 1 hit.
    PfamiPF01150. GDA1_CD39. 1 hit.
    [Graphical view]
    PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9USP2-1 [UniParc]FASTAAdd to Basket

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    MVRKYGIFID AGSSGSRLLI YSWDYDTDSS LSDKVKKLPL IETGIGDGGK    50
    WSLKVQPGIS SFANNPKHVG KKHLKELLDF AAHAIPKDVH KETPVFLSAT 100
    AGMRLLGVDA QNKILSHACR YIKKNYDFDI PNCSNSIRVI DGKAEGMYGW 150
    LATNYLLKTL EEKDTSTVGF LDMGGASVQI AFELPPSQLK NYKDSISTVH 200
    IGLQNGQQLE YPLFVTTWLG FGANEAYRRY LGLLIESENG KVGNTLSDPC 250
    SLRGRTYDID GIEFAGTGDL KQCLKLTYNL LNKDKPCSMD PCNFDGISIP 300
    PVDFANTEFV GVSEFWYTTN DVFDMGGSYH FPNFYKKVDE YCGTEWETML 350
    SRLYNKELTP STDENKLEKL CFKASWALNV LHEGFDVPKS NTSSNDAKDG 400
    LSVIPAYHSP FTSLEKIERT EVSWTLGQVL LYASNQQLLA KPEYANYYMD 450
    PYGKLIASPS KHWMRLFPNK LFFILSFIFC LFFLFSLVLF GYDPKRRQRF 500
    KKFLLRLQRR KAPYIMSANG SYEDIADFSD DLEMSSPSKW HGPPIRTTSS 550
    HVLADRLSFT ASRERTPRSP FP 572
    Length:572
    Mass (Da):64,680
    Last modified:May 1, 2000 - v1
    Checksum:i8E039FBFA0D3B482
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB57847.1.
    PIRiT40856.
    RefSeqiNP_588201.1. NM_001023191.2.

    Genome annotation databases

    EnsemblFungiiSPCC11E10.05c.1; SPCC11E10.05c.1:pep; SPCC11E10.05c.
    GeneIDi2538741.
    KEGGispo:SPCC11E10.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB57847.1 .
    PIRi T40856.
    RefSeqi NP_588201.1. NM_001023191.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275324. 11 interactions.
    MINTi MINT-4708352.
    STRINGi 4896.SPCC11E10.05c-1.

    Proteomic databases

    MaxQBi Q9USP2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC11E10.05c.1 ; SPCC11E10.05c.1:pep ; SPCC11E10.05c .
    GeneIDi 2538741.
    KEGGi spo:SPCC11E10.05c.

    Organism-specific databases

    PomBasei SPCC11E10.05c.

    Phylogenomic databases

    eggNOGi COG5371.
    HOGENOMi HOG000246725.
    OMAi LVCAKEH.
    OrthoDBi EOG7QK0PD.
    PhylomeDBi Q9USP2.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 20799925.

    Family and domain databases

    InterProi IPR000407. GDA1_CD39_NTPase.
    [Graphical view ]
    PANTHERi PTHR11782. PTHR11782. 1 hit.
    Pfami PF01150. GDA1_CD39. 1 hit.
    [Graphical view ]
    PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Nucleoside diphosphatase and glycosyltransferase activities can localize to different subcellular compartments in Schizosaccharomyces pombe."
      D'Alessio C., Trombetta E.S., Parodi A.J.
      J. Biol. Chem. 278:22379-22387(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME ACTIVITY, COFACTOR, SUBCELLULAR LOCATION.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYND1_SCHPO
    AccessioniPrimary (citable) accession number: Q9USP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3