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Protein

Golgi apyrase

Gene

ynd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Required for Golgi glycosylation and cell wall integrity. Involved in N-mannosylation of proteins in Golgi.By similarity1 Publication

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.1 Publication

Cofactori

Ca2+1 Publication, Mg2+1 Publication, Mn2+1 PublicationNote: Divalent metal cations. Ca2+, Mg2+ or Mn2+.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei145Proton acceptorBy similarity1

GO - Molecular functioni

  • adenosine-diphosphatase activity Source: PomBase
  • ATPase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • cytidine diphosphatase activity Source: PomBase
  • GTPase activity Source: PomBase
  • guanosine-diphosphatase activity Source: PomBase
  • nucleoside-triphosphate diphosphatase activity Source: PomBase
  • uridine-diphosphatase activity Source: PomBase

GO - Biological processi

  • ADP catabolic process Source: PomBase
  • CDP catabolic process Source: PomBase
  • GDP catabolic process Source: PomBase
  • protein glycosylation Source: UniProtKB-UniPathway
  • UDP catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-8850843. Phosphate bond hydrolysis by NTPDase proteins.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apyrase1 Publication (EC:3.6.1.5)
Alternative name(s):
ATP-diphosphataseBy similarity
ATP-diphosphohydrolaseBy similarity
Adenosine diphosphataseBy similarity
Short name:
ADPaseBy similarity
Golgi nucleoside diphosphataseBy similarity
Gene namesi
Name:ynd1Imported
ORF Names:SPCC11E10.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.05c.
PomBaseiSPCC11E10.05c. ynd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 470LumenalSequence analysisBy similarityAdd BLAST470
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 572CytoplasmicSequence analysisBy similarityAdd BLAST81

GO - Cellular componenti

  • Golgi apparatus Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472821 – 572Golgi apyraseAdd BLAST572

Proteomic databases

MaxQBiQ9USP2.
PRIDEiQ9USP2.

Interactioni

Protein-protein interaction databases

BioGridi275324. 11 interactors.
MINTiMINT-4708352.

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246725.
InParanoidiQ9USP2.
KOiK14642.
OMAiYQRQLWG.
OrthoDBiEOG092C1F34.
PhylomeDBiQ9USP2.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKYGIFID AGSSGSRLLI YSWDYDTDSS LSDKVKKLPL IETGIGDGGK
60 70 80 90 100
WSLKVQPGIS SFANNPKHVG KKHLKELLDF AAHAIPKDVH KETPVFLSAT
110 120 130 140 150
AGMRLLGVDA QNKILSHACR YIKKNYDFDI PNCSNSIRVI DGKAEGMYGW
160 170 180 190 200
LATNYLLKTL EEKDTSTVGF LDMGGASVQI AFELPPSQLK NYKDSISTVH
210 220 230 240 250
IGLQNGQQLE YPLFVTTWLG FGANEAYRRY LGLLIESENG KVGNTLSDPC
260 270 280 290 300
SLRGRTYDID GIEFAGTGDL KQCLKLTYNL LNKDKPCSMD PCNFDGISIP
310 320 330 340 350
PVDFANTEFV GVSEFWYTTN DVFDMGGSYH FPNFYKKVDE YCGTEWETML
360 370 380 390 400
SRLYNKELTP STDENKLEKL CFKASWALNV LHEGFDVPKS NTSSNDAKDG
410 420 430 440 450
LSVIPAYHSP FTSLEKIERT EVSWTLGQVL LYASNQQLLA KPEYANYYMD
460 470 480 490 500
PYGKLIASPS KHWMRLFPNK LFFILSFIFC LFFLFSLVLF GYDPKRRQRF
510 520 530 540 550
KKFLLRLQRR KAPYIMSANG SYEDIADFSD DLEMSSPSKW HGPPIRTTSS
560 570
HVLADRLSFT ASRERTPRSP FP
Length:572
Mass (Da):64,680
Last modified:May 1, 2000 - v1
Checksum:i8E039FBFA0D3B482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB57847.1.
PIRiT40856.
RefSeqiNP_588201.1. NM_001023191.2.

Genome annotation databases

EnsemblFungiiSPCC11E10.05c.1; SPCC11E10.05c.1:pep; SPCC11E10.05c.
GeneIDi2538741.
KEGGispo:SPCC11E10.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB57847.1.
PIRiT40856.
RefSeqiNP_588201.1. NM_001023191.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275324. 11 interactors.
MINTiMINT-4708352.

Proteomic databases

MaxQBiQ9USP2.
PRIDEiQ9USP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC11E10.05c.1; SPCC11E10.05c.1:pep; SPCC11E10.05c.
GeneIDi2538741.
KEGGispo:SPCC11E10.05c.

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.05c.
PomBaseiSPCC11E10.05c. ynd1.

Phylogenomic databases

HOGENOMiHOG000246725.
InParanoidiQ9USP2.
KOiK14642.
OMAiYQRQLWG.
OrthoDBiEOG092C1F34.
PhylomeDBiQ9USP2.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-SPO-8850843. Phosphate bond hydrolysis by NTPDase proteins.

Miscellaneous databases

PROiQ9USP2.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYND1_SCHPO
AccessioniPrimary (citable) accession number: Q9USP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.