Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translation initiation factor eIF-2B subunit alpha

Gene

tif221

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: PomBase
  • translation initiation factor activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit alpha
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit alpha
Gene namesi
Name:tif221
ORF Names:SPCC11E10.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.07c.
PomBaseiSPCC11E10.07c. tif221.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • eukaryotic translation initiation factor 2B complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Translation initiation factor eIF-2B subunit alphaPRO_0000156059Add
BLAST

Proteomic databases

MaxQBiQ9USP0.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Protein-protein interaction databases

BioGridi275726. 18 interactions.
IntActiQ9USP0. 1 interaction.
MINTiMINT-4708334.

Structurei

Secondary structure

1
341
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 2911Combined sources
Helixi35 – 4612Combined sources
Helixi55 – 584Combined sources
Turni59 – 624Combined sources
Helixi63 – 7210Combined sources
Beta strandi73 – 753Combined sources
Helixi77 – 9418Combined sources
Turni95 – 973Combined sources
Helixi101 – 1099Combined sources
Turni110 – 1145Combined sources
Helixi115 – 12915Combined sources
Helixi130 – 1323Combined sources
Beta strandi137 – 1437Combined sources
Helixi146 – 15712Combined sources
Beta strandi162 – 1676Combined sources
Turni170 – 1734Combined sources
Helixi174 – 18411Combined sources
Beta strandi189 – 1924Combined sources
Helixi198 – 2036Combined sources
Beta strandi205 – 2106Combined sources
Beta strandi212 – 2143Combined sources
Beta strandi220 – 2234Combined sources
Helixi226 – 23510Combined sources
Beta strandi240 – 2434Combined sources
Helixi246 – 2483Combined sources
Helixi299 – 3024Combined sources
Beta strandi307 – 3115Combined sources
Helixi313 – 3153Combined sources
Beta strandi317 – 3215Combined sources
Beta strandi324 – 3263Combined sources
Beta strandi328 – 3303Combined sources
Helixi331 – 3399Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99A/B1-341[»]
ProteinModelPortaliQ9USP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000175731.
InParanoidiQ9USP0.
KOiK03239.
OMAiTHKFVRK.
OrthoDBiEOG092C2Z6R.
PhylomeDBiQ9USP0.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVESDSSGIV RHSQGEFDIV QVYKKFLQDD PEITMPVAAI EALVQLLSRS
60 70 80 90 100
QAKTISEFMD ILQNGSNTLK EGVQNNISLS AGCDIFQRFV TRSLHDVGDF
110 120 130 140 150
EQCKRHLVEN GKLFIQRARA CRQRIAHLGY PLIRDGSVIL THGFSRGVAA
160 170 180 190 200
VLLAAAKRHV RFKVFVTESR PSGSGCLMTR TLKNACIPTC MVLDSAVSFT
210 220 230 240 250
MNRVDLVLVG AEGVVENGGL INQIGTFQLA VFAKHAHKPF YAVAESHKFV
260 270 280 290 300
RMFPLSQYDI PFSRPILEFD DPSPETVHPE PEPIPTPSDA IHNELIMNEE
310 320 330 340
QIRNNPTLDV TPPEFVSGLI TDLGIIDSKS GVSEELIKLY L
Length:341
Mass (Da):37,773
Last modified:May 1, 2000 - v1
Checksum:i6FAACEBEBD50995A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB57849.1.
PIRiT40858.
RefSeqiNP_588203.1. NM_001023193.2.

Genome annotation databases

EnsemblFungiiSPCC11E10.07c.1; SPCC11E10.07c.1:pep; SPCC11E10.07c.
GeneIDi2539154.
KEGGispo:SPCC11E10.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB57849.1.
PIRiT40858.
RefSeqiNP_588203.1. NM_001023193.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99A/B1-341[»]
ProteinModelPortaliQ9USP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275726. 18 interactions.
IntActiQ9USP0. 1 interaction.
MINTiMINT-4708334.

Proteomic databases

MaxQBiQ9USP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC11E10.07c.1; SPCC11E10.07c.1:pep; SPCC11E10.07c.
GeneIDi2539154.
KEGGispo:SPCC11E10.07c.

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.07c.
PomBaseiSPCC11E10.07c. tif221.

Phylogenomic databases

HOGENOMiHOG000175731.
InParanoidiQ9USP0.
KOiK03239.
OMAiTHKFVRK.
OrthoDBiEOG092C2Z6R.
PhylomeDBiQ9USP0.

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Miscellaneous databases

PROiQ9USP0.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BA_SCHPO
AccessioniPrimary (citable) accession number: Q9USP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.