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Protein

Translation initiation factor eIF-2B subunit alpha

Gene

tif221

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: PomBase
  • translation initiation factor activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit alpha
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit alpha
Gene namesi
Name:tif221
ORF Names:SPCC11E10.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.07c.
PomBaseiSPCC11E10.07c. tif221.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • eukaryotic translation initiation factor 2B complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560591 – 341Translation initiation factor eIF-2B subunit alphaAdd BLAST341

Proteomic databases

MaxQBiQ9USP0.
PRIDEiQ9USP0.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Protein-protein interaction databases

BioGridi275726. 18 interactors.
DIPiDIP-61958N.
IntActiQ9USP0. 1 interactor.
MINTiMINT-4708334.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 29Combined sources11
Helixi35 – 46Combined sources12
Helixi55 – 58Combined sources4
Turni59 – 62Combined sources4
Helixi63 – 72Combined sources10
Beta strandi73 – 75Combined sources3
Helixi77 – 94Combined sources18
Turni95 – 97Combined sources3
Helixi101 – 109Combined sources9
Turni110 – 114Combined sources5
Helixi115 – 129Combined sources15
Helixi130 – 132Combined sources3
Beta strandi137 – 143Combined sources7
Helixi146 – 157Combined sources12
Beta strandi162 – 167Combined sources6
Turni170 – 173Combined sources4
Helixi174 – 184Combined sources11
Beta strandi189 – 192Combined sources4
Helixi198 – 203Combined sources6
Beta strandi205 – 210Combined sources6
Beta strandi212 – 214Combined sources3
Beta strandi220 – 223Combined sources4
Helixi226 – 235Combined sources10
Beta strandi240 – 243Combined sources4
Helixi246 – 248Combined sources3
Helixi299 – 302Combined sources4
Beta strandi307 – 311Combined sources5
Helixi313 – 315Combined sources3
Beta strandi317 – 321Combined sources5
Beta strandi324 – 326Combined sources3
Beta strandi328 – 330Combined sources3
Helixi331 – 339Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99A/B1-341[»]
ProteinModelPortaliQ9USP0.
SMRiQ9USP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000175731.
InParanoidiQ9USP0.
KOiK03239.
OMAiTHKFVRK.
OrthoDBiEOG092C2Z6R.
PhylomeDBiQ9USP0.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVESDSSGIV RHSQGEFDIV QVYKKFLQDD PEITMPVAAI EALVQLLSRS
60 70 80 90 100
QAKTISEFMD ILQNGSNTLK EGVQNNISLS AGCDIFQRFV TRSLHDVGDF
110 120 130 140 150
EQCKRHLVEN GKLFIQRARA CRQRIAHLGY PLIRDGSVIL THGFSRGVAA
160 170 180 190 200
VLLAAAKRHV RFKVFVTESR PSGSGCLMTR TLKNACIPTC MVLDSAVSFT
210 220 230 240 250
MNRVDLVLVG AEGVVENGGL INQIGTFQLA VFAKHAHKPF YAVAESHKFV
260 270 280 290 300
RMFPLSQYDI PFSRPILEFD DPSPETVHPE PEPIPTPSDA IHNELIMNEE
310 320 330 340
QIRNNPTLDV TPPEFVSGLI TDLGIIDSKS GVSEELIKLY L
Length:341
Mass (Da):37,773
Last modified:May 1, 2000 - v1
Checksum:i6FAACEBEBD50995A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB57849.1.
PIRiT40858.
RefSeqiNP_588203.1. NM_001023193.2.

Genome annotation databases

EnsemblFungiiSPCC11E10.07c.1; SPCC11E10.07c.1:pep; SPCC11E10.07c.
GeneIDi2539154.
KEGGispo:SPCC11E10.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB57849.1.
PIRiT40858.
RefSeqiNP_588203.1. NM_001023193.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99A/B1-341[»]
ProteinModelPortaliQ9USP0.
SMRiQ9USP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275726. 18 interactors.
DIPiDIP-61958N.
IntActiQ9USP0. 1 interactor.
MINTiMINT-4708334.

Proteomic databases

MaxQBiQ9USP0.
PRIDEiQ9USP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC11E10.07c.1; SPCC11E10.07c.1:pep; SPCC11E10.07c.
GeneIDi2539154.
KEGGispo:SPCC11E10.07c.

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.07c.
PomBaseiSPCC11E10.07c. tif221.

Phylogenomic databases

HOGENOMiHOG000175731.
InParanoidiQ9USP0.
KOiK03239.
OMAiTHKFVRK.
OrthoDBiEOG092C2Z6R.
PhylomeDBiQ9USP0.

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Miscellaneous databases

PROiQ9USP0.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BA_SCHPO
AccessioniPrimary (citable) accession number: Q9USP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.