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Protein

NAD-dependent protein deacetylase hst2

Gene

hst2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.By similarity

Catalytic activityi

NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.PROSITE-ProRule annotation

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381Proton acceptorPROSITE-ProRule annotation
Metal bindingi146 – 1461ZincPROSITE-ProRule annotation
Metal bindingi149 – 1491ZincPROSITE-ProRule annotation
Metal bindingi170 – 1701ZincPROSITE-ProRule annotation
Metal bindingi173 – 1731ZincPROSITE-ProRule annotation
Binding sitei255 – 2551NAD; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 5521NADBy similarityAdd
BLAST
Nucleotide bindingi118 – 1214NADBy similarity
Nucleotide bindingi210 – 2123NADBy similarity
Nucleotide bindingi235 – 2373NADBy similarity

GO - Molecular functioni

  • NAD+ binding Source: InterPro
  • NAD-dependent histone deacetylase activity Source: PomBase
  • protein deacetylase activity Source: PomBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at centromere outer repeat region Source: PomBase
  • chromatin silencing at rDNA Source: PomBase
  • histone H3-K9 deacetylation Source: PomBase
  • protein deacetylation Source: PomBase
  • regulation of nucleosome density Source: PomBase
  • regulation of transport by negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent protein deacetylase hst2 (EC:3.5.1.-)
Alternative name(s):
Homologous to sir2 protein 2
Regulatory protein SIR2 homolog 2
Gene namesi
Name:hst2
ORF Names:SPCC132.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC132.02.
PomBaseiSPCC132.02. hst2.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric outer repeat region Source: GOC
  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mating-type region heterochromatin Source: PomBase
  • nuclear chromatin Source: PomBase
  • nuclear pericentric heterochromatin Source: PomBase
  • nuclear rDNA heterochromatin Source: PomBase
  • nuclear subtelomeric heterochromatin Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332NAD-dependent protein deacetylase hst2PRO_0000316618Add
BLAST

Proteomic databases

MaxQBiQ9USN7.

Interactioni

Protein-protein interaction databases

BioGridi275448. 32 interactions.
MINTiMINT-4708315.

Structurei

3D structure databases

ProteinModelPortaliQ9USN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 271256Deacetylase sirtuin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sirtuin family. Class I subfamily.Curated
Contains 1 deacetylase sirtuin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000085952.
InParanoidiQ9USN7.
KOiK11121.
OMAiHCPRVLI.
OrthoDBiEOG092C1NXT.
PhylomeDBiQ9USN7.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR017328. Sirtuin_class_I.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
PIRSFiPIRSF037938. SIR2_euk. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKNTVKHVD SSKHLEKVAS LIKEGKVKKI CVMVGAGIST AAGIPDFRSP
60 70 80 90 100
ETGIYNNLQR FNLPYAEAVF DLSYFRKNPR PFYELAHELM PEKYRPTYTH
110 120 130 140 150
YFIRLLHDKR LLQKCYTQNI DTLERLAGVP DKALIEAHGS FQYSRCIECY
160 170 180 190 200
EMAETEYVRA CIMQKQVPKC NSCKGLIKPM IVFYGEGLPM RFFEHMEKDT
210 220 230 240 250
KVCDMALVIG TSLLVHPFAD LPEIVPNKCQ RVLINREPAG DFGERKKDIM
260 270 280 290 300
ILGDCDSQVR ALCKLLGWSD ELEKLIDTSV ETLTEEISLL SVDSTIEKNA
310 320 330
SEQKKDDNSV NPFTKIEEKK KDEVTLLVSD DE
Length:332
Mass (Da):37,916
Last modified:May 1, 2000 - v1
Checksum:i936A08D240C8BCFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB58129.1.
PIRiT40929.
RefSeqiNP_588147.1. NM_001023136.2.

Genome annotation databases

EnsemblFungiiSPCC132.02.1; SPCC132.02.1:pep; SPCC132.02.
GeneIDi2538868.
KEGGispo:SPCC132.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB58129.1.
PIRiT40929.
RefSeqiNP_588147.1. NM_001023136.2.

3D structure databases

ProteinModelPortaliQ9USN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275448. 32 interactions.
MINTiMINT-4708315.

Proteomic databases

MaxQBiQ9USN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC132.02.1; SPCC132.02.1:pep; SPCC132.02.
GeneIDi2538868.
KEGGispo:SPCC132.02.

Organism-specific databases

EuPathDBiFungiDB:SPCC132.02.
PomBaseiSPCC132.02. hst2.

Phylogenomic databases

HOGENOMiHOG000085952.
InParanoidiQ9USN7.
KOiK11121.
OMAiHCPRVLI.
OrthoDBiEOG092C1NXT.
PhylomeDBiQ9USN7.

Miscellaneous databases

PROiQ9USN7.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR017328. Sirtuin_class_I.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
PIRSFiPIRSF037938. SIR2_euk. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHST2_SCHPO
AccessioniPrimary (citable) accession number: Q9USN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.