SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9USM5

- UBP1_SCHPO

UniProt

Q9USM5 - UBP1_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable ubiquitin carboxyl-terminal hydrolase 1
Gene
ubp1, SPCC16A11.12c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei288 – 2881Nucleophile By similarity
Active sitei806 – 8061Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. protein deubiquitination Source: PomBase
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A55.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 1
Ubiquitin thioesterase 1
Ubiquitin-specific-processing protease 1
Gene namesi
Name:ubp1
ORF Names:SPCC16A11.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC16A11.12c.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 849849Probable ubiquitin carboxyl-terminal hydrolase 1
PRO_0000080602Add
BLAST

Proteomic databases

MaxQBiQ9USM5.

Interactioni

Protein-protein interaction databases

STRINGi4896.SPCC16A11.12c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9USM5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 120101DUSP
Add
BLAST
Domaini279 – 848570USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 DUSP domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5560.
KOiK11870.
OMAiTAIGFND.
OrthoDBiEOG7R2BSX.
PhylomeDBiQ9USM5.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF06337. DUSP. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
PROSITEiPS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USM5-1 [UniParc]FASTAAdd to Basket

« Hide

MASTATQNAS TRYSQIWIDQ PASLPFQDSI NLIKEDKEKW KKEKTAFLID    50
YDWFEGYVDF IYGEGDNPGP ITQWRLLDEK NELKHSLEES IDYSIVSASL 100
WHMLVEWFGL EGLAIERKVL LVGLAAEQKP FVDIYPINFT LHVLFDPING 150
ENTSYSPLYQ IDEPYHSDEP YAFSFSRSDT LRSLYKQVME AFQISDGTSF 200
RLWYLNKSNL SSRFVSLSEF NDQPAIALLS EYAVCMTIFE IDIADGSLLL 250
EFQHPNGEWL SDSITKEQNL TINKEIGLCG LYNLGNSCYM NSALQCMIHT 300
HELTKYFLSD SYEKDINYNN PLGMMGKVAL SYASLLKMIH HTADMHSVSP 350
SSFKFIIGEF NTYFSGYRQQ DSQEFIAFFL DGLHEDLNRI QIKPYFERPD 400
LFDEHPLHVQ RVANQCWDIH TKRNDSIIVQ LFQGMYKSTL ECSICYQKST 450
AFDPFMYLTL PLPTSAKWRH KVVYVPPFGT QSPVELYLEL LMESTVIQMK 500
FQATEKLQKM GLECGELTAC DIYRGKVYKV LKNKDKISKK IHKWDHVVLY 550
GSTANGLTIP IVHGCKRPAM PGSYQSNDVF GFPLQLNVRS RNVLTNDLVK 600
EIVELYRVYA GIDVAIGTLQ LGLKRMESKA GKWECIKEIE VKRFEIVEEE 650
EIVIDDKTVI MCLWNDQQYE KLFYNCEWIF EKIQFHMESI TLEDCLLEFS 700
KPEQLDLQDS WYCPGCKAFR PATKRLEIWR LPKILVIHLN RFSGHGGDLR 750
RRRKRRDLVV YPVFDLNLKQ FLSPFIKDHE WLSSQKSMLY DLYAVDNHHG 800
FMSNGHYTAY ARDASSQTFF KFDDTAICEI DPEDIVTSSA YVLFYRAKN 849
Length:849
Mass (Da):98,656
Last modified:May 1, 2000 - v1
Checksum:iC8118042229BA9CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB53084.1.
PIRiT41085.
RefSeqiNP_587999.1. NM_001022990.2.

Genome annotation databases

EnsemblFungiiSPCC16A11.12c.1; SPCC16A11.12c.1:pep; SPCC16A11.12c.
GeneIDi2539228.
KEGGispo:SPCC16A11.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB53084.1 .
PIRi T41085.
RefSeqi NP_587999.1. NM_001022990.2.

3D structure databases

ProteinModelPortali Q9USM5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 4896.SPCC16A11.12c-1.

Protein family/group databases

MEROPSi C19.A55.

Proteomic databases

MaxQBi Q9USM5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC16A11.12c.1 ; SPCC16A11.12c.1:pep ; SPCC16A11.12c .
GeneIDi 2539228.
KEGGi spo:SPCC16A11.12c.

Organism-specific databases

PomBasei SPCC16A11.12c.

Phylogenomic databases

eggNOGi COG5560.
KOi K11870.
OMAi TAIGFND.
OrthoDBi EOG7R2BSX.
PhylomeDBi Q9USM5.

Miscellaneous databases

NextBioi 20800398.

Family and domain databases

Gene3Di 3.30.2230.10. 1 hit.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF06337. DUSP. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00695. DUSP. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 1 hit.
PROSITEi PS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiUBP1_SCHPO
AccessioniPrimary (citable) accession number: Q9USM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi