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Protein

Probable ubiquitin carboxyl-terminal hydrolase 1

Gene

ubp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei288NucleophilePROSITE-ProRule annotation1
Active sitei806Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.A55

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 1
Ubiquitin thioesterase 1
Ubiquitin-specific-processing protease 1
Gene namesi
Name:ubp1
ORF Names:SPCC16A11.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16A11.12c
PomBaseiSPCC16A11.12c ubp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806021 – 849Probable ubiquitin carboxyl-terminal hydrolase 1Add BLAST849

Proteomic databases

MaxQBiQ9USM5
PaxDbiQ9USM5
PRIDEiQ9USM5

Interactioni

Protein-protein interaction databases

BioGridi2757981 interactor.
STRINGi4896.SPCC16A11.12c.1

Structurei

3D structure databases

ProteinModelPortaliQ9USM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 120DUSPPROSITE-ProRule annotationAdd BLAST101
Domaini279 – 848USPAdd BLAST570

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

InParanoidiQ9USM5
KOiK11835
OrthoDBiEOG092C5R71
PhylomeDBiQ9USM5

Family and domain databases

InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR028134 USP4
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR43913 PTHR43913, 2 hits
PfamiView protein in Pfam
PF06337 DUSP, 1 hit
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9USM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTATQNAS TRYSQIWIDQ PASLPFQDSI NLIKEDKEKW KKEKTAFLID
60 70 80 90 100
YDWFEGYVDF IYGEGDNPGP ITQWRLLDEK NELKHSLEES IDYSIVSASL
110 120 130 140 150
WHMLVEWFGL EGLAIERKVL LVGLAAEQKP FVDIYPINFT LHVLFDPING
160 170 180 190 200
ENTSYSPLYQ IDEPYHSDEP YAFSFSRSDT LRSLYKQVME AFQISDGTSF
210 220 230 240 250
RLWYLNKSNL SSRFVSLSEF NDQPAIALLS EYAVCMTIFE IDIADGSLLL
260 270 280 290 300
EFQHPNGEWL SDSITKEQNL TINKEIGLCG LYNLGNSCYM NSALQCMIHT
310 320 330 340 350
HELTKYFLSD SYEKDINYNN PLGMMGKVAL SYASLLKMIH HTADMHSVSP
360 370 380 390 400
SSFKFIIGEF NTYFSGYRQQ DSQEFIAFFL DGLHEDLNRI QIKPYFERPD
410 420 430 440 450
LFDEHPLHVQ RVANQCWDIH TKRNDSIIVQ LFQGMYKSTL ECSICYQKST
460 470 480 490 500
AFDPFMYLTL PLPTSAKWRH KVVYVPPFGT QSPVELYLEL LMESTVIQMK
510 520 530 540 550
FQATEKLQKM GLECGELTAC DIYRGKVYKV LKNKDKISKK IHKWDHVVLY
560 570 580 590 600
GSTANGLTIP IVHGCKRPAM PGSYQSNDVF GFPLQLNVRS RNVLTNDLVK
610 620 630 640 650
EIVELYRVYA GIDVAIGTLQ LGLKRMESKA GKWECIKEIE VKRFEIVEEE
660 670 680 690 700
EIVIDDKTVI MCLWNDQQYE KLFYNCEWIF EKIQFHMESI TLEDCLLEFS
710 720 730 740 750
KPEQLDLQDS WYCPGCKAFR PATKRLEIWR LPKILVIHLN RFSGHGGDLR
760 770 780 790 800
RRRKRRDLVV YPVFDLNLKQ FLSPFIKDHE WLSSQKSMLY DLYAVDNHHG
810 820 830 840
FMSNGHYTAY ARDASSQTFF KFDDTAICEI DPEDIVTSSA YVLFYRAKN
Length:849
Mass (Da):98,656
Last modified:May 1, 2000 - v1
Checksum:iC8118042229BA9CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB53084.1
PIRiT41085
RefSeqiNP_587999.1, NM_001022990.2

Genome annotation databases

EnsemblFungiiSPCC16A11.12c.1; SPCC16A11.12c.1:pep; SPCC16A11.12c
GeneIDi2539228
KEGGispo:SPCC16A11.12c

Entry informationi

Entry nameiUBP1_SCHPO
AccessioniPrimary (citable) accession number: Q9USM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome