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Q9USM5

- UBP1_SCHPO

UniProt

Q9USM5 - UBP1_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 1

Gene

ubp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei288 – 2881NucleophilePROSITE-ProRule annotation
    Active sitei806 – 8061Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A55.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 1
    Ubiquitin thioesterase 1
    Ubiquitin-specific-processing protease 1
    Gene namesi
    Name:ubp1
    ORF Names:SPCC16A11.12c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC16A11.12c.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 849849Probable ubiquitin carboxyl-terminal hydrolase 1PRO_0000080602Add
    BLAST

    Proteomic databases

    MaxQBiQ9USM5.

    Interactioni

    Protein-protein interaction databases

    STRINGi4896.SPCC16A11.12c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9USM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 120101DUSPPROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 848570USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 DUSP domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    KOiK11870.
    OMAiTAIGFND.
    OrthoDBiEOG7R2BSX.
    PhylomeDBiQ9USM5.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    PROSITEiPS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9USM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTATQNAS TRYSQIWIDQ PASLPFQDSI NLIKEDKEKW KKEKTAFLID    50
    YDWFEGYVDF IYGEGDNPGP ITQWRLLDEK NELKHSLEES IDYSIVSASL 100
    WHMLVEWFGL EGLAIERKVL LVGLAAEQKP FVDIYPINFT LHVLFDPING 150
    ENTSYSPLYQ IDEPYHSDEP YAFSFSRSDT LRSLYKQVME AFQISDGTSF 200
    RLWYLNKSNL SSRFVSLSEF NDQPAIALLS EYAVCMTIFE IDIADGSLLL 250
    EFQHPNGEWL SDSITKEQNL TINKEIGLCG LYNLGNSCYM NSALQCMIHT 300
    HELTKYFLSD SYEKDINYNN PLGMMGKVAL SYASLLKMIH HTADMHSVSP 350
    SSFKFIIGEF NTYFSGYRQQ DSQEFIAFFL DGLHEDLNRI QIKPYFERPD 400
    LFDEHPLHVQ RVANQCWDIH TKRNDSIIVQ LFQGMYKSTL ECSICYQKST 450
    AFDPFMYLTL PLPTSAKWRH KVVYVPPFGT QSPVELYLEL LMESTVIQMK 500
    FQATEKLQKM GLECGELTAC DIYRGKVYKV LKNKDKISKK IHKWDHVVLY 550
    GSTANGLTIP IVHGCKRPAM PGSYQSNDVF GFPLQLNVRS RNVLTNDLVK 600
    EIVELYRVYA GIDVAIGTLQ LGLKRMESKA GKWECIKEIE VKRFEIVEEE 650
    EIVIDDKTVI MCLWNDQQYE KLFYNCEWIF EKIQFHMESI TLEDCLLEFS 700
    KPEQLDLQDS WYCPGCKAFR PATKRLEIWR LPKILVIHLN RFSGHGGDLR 750
    RRRKRRDLVV YPVFDLNLKQ FLSPFIKDHE WLSSQKSMLY DLYAVDNHHG 800
    FMSNGHYTAY ARDASSQTFF KFDDTAICEI DPEDIVTSSA YVLFYRAKN 849
    Length:849
    Mass (Da):98,656
    Last modified:May 1, 2000 - v1
    Checksum:iC8118042229BA9CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB53084.1.
    PIRiT41085.
    RefSeqiNP_587999.1. NM_001022990.2.

    Genome annotation databases

    EnsemblFungiiSPCC16A11.12c.1; SPCC16A11.12c.1:pep; SPCC16A11.12c.
    GeneIDi2539228.
    KEGGispo:SPCC16A11.12c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB53084.1 .
    PIRi T41085.
    RefSeqi NP_587999.1. NM_001022990.2.

    3D structure databases

    ProteinModelPortali Q9USM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4896.SPCC16A11.12c-1.

    Protein family/group databases

    MEROPSi C19.A55.

    Proteomic databases

    MaxQBi Q9USM5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC16A11.12c.1 ; SPCC16A11.12c.1:pep ; SPCC16A11.12c .
    GeneIDi 2539228.
    KEGGi spo:SPCC16A11.12c.

    Organism-specific databases

    PomBasei SPCC16A11.12c.

    Phylogenomic databases

    eggNOGi COG5560.
    KOi K11870.
    OMAi TAIGFND.
    OrthoDBi EOG7R2BSX.
    PhylomeDBi Q9USM5.

    Miscellaneous databases

    NextBioi 20800398.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    PROSITEi PS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiUBP1_SCHPO
    AccessioniPrimary (citable) accession number: Q9USM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3