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Q9USL6

- YJK5_SCHPO

UniProt

Q9USL6 - YJK5_SCHPO

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Protein

Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c

Gene

SPCC18B5.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: PomBase

GO - Biological processi

  1. thiamine biosynthetic process Source: PomBase
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
ORF Names:SPCC18B5.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC18B5.05c.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05cPRO_0000343140Add
BLAST

Proteomic databases

MaxQBiQ9USL6.

Interactioni

Protein-protein interaction databases

BioGridi275587. 28 interactions.
MINTiMINT-4708190.
STRINGi4896.SPCC18B5.05c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9USL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.Curated

Phylogenomic databases

eggNOGiCOG0351.
InParanoidiQ9USL6.
OMAiRGVYGMG.
OrthoDBiEOG75MW5D.
PhylomeDBiQ9USL6.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9USL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEANQSHNAK TNHPTCLTIA GSDCSGAAGI QADLKVMTAH QVYGMSVLTA
60 70 80 90 100
LTCQNSHGIT GIYPLHPSLI QRQIDACLSD IQCRVVKIGM LPDPKSIPVI
110 120 130 140 150
SQALTKYKIT DVVMDSVIIS SMGNVMCETP TIPATIQHLF PHLLVYASNV
160 170 180 190 200
MEAFILVEKT LKKSPPPLKS FPDIQNLMSI IHRLGPKFVV LRGHHVAFDK
210 220 230 240 250
NMMITEKPDS KSWTADLIYD GKEFYIFEKP YNTTKSIHGE SCSLTAAIAS
260 270 280 290 300
NLACNIPPLQ AIHEALYSIE WAIQRVHKKS SDPYKSAQLF TALGHSSKFS
310 320
GSLISLKSEN YIPQADLTSV LLSHIPS
Length:327
Mass (Da):35,840
Last modified:May 1, 2000 - v1
Checksum:i60632515D4D9C050
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB52152.1.
PIRiT41198.
RefSeqiNP_587935.1. NM_001022926.2.

Genome annotation databases

EnsemblFungiiSPCC18B5.05c.1; SPCC18B5.05c.1:pep; SPCC18B5.05c.
GeneIDi2539014.
KEGGispo:SPCC18B5.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB52152.1 .
PIRi T41198.
RefSeqi NP_587935.1. NM_001022926.2.

3D structure databases

ProteinModelPortali Q9USL6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275587. 28 interactions.
MINTi MINT-4708190.
STRINGi 4896.SPCC18B5.05c-1.

Proteomic databases

MaxQBi Q9USL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC18B5.05c.1 ; SPCC18B5.05c.1:pep ; SPCC18B5.05c .
GeneIDi 2539014.
KEGGi spo:SPCC18B5.05c.

Organism-specific databases

PomBasei SPCC18B5.05c.

Phylogenomic databases

eggNOGi COG0351.
InParanoidi Q9USL6.
OMAi RGVYGMG.
OrthoDBi EOG75MW5D.
PhylomeDBi Q9USL6.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .

Miscellaneous databases

NextBioi 20800188.
PROi Q9USL6.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYJK5_SCHPO
AccessioniPrimary (citable) accession number: Q9USL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3