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Protein

Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c

Gene

SPCC18B5.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway: thiamine diphosphate biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 (SPBP8B7.18c), Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c (SPCC18B5.05c), Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1 (SPBP8B7.17c)
  3. Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 (SPBP8B7.18c), Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c (SPCC18B5.05c), Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1 (SPBP8B7.17c)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
ORF Names:SPCC18B5.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC18B5.05c.
PomBaseiSPCC18B5.05c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05cPRO_0000343140Add
BLAST

Proteomic databases

MaxQBiQ9USL6.

Interactioni

Protein-protein interaction databases

BioGridi275587. 28 interactions.
MINTiMINT-4708190.
STRINGi4896.SPCC18B5.05c.1.

Structurei

3D structure databases

ProteinModelPortaliQ9USL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.Curated

Phylogenomic databases

eggNOGiCOG0351.
InParanoidiQ9USL6.
KOiK00877.
OMAiRGVYGMG.
OrthoDBiEOG75MW5D.
PhylomeDBiQ9USL6.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9USL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANQSHNAK TNHPTCLTIA GSDCSGAAGI QADLKVMTAH QVYGMSVLTA
60 70 80 90 100
LTCQNSHGIT GIYPLHPSLI QRQIDACLSD IQCRVVKIGM LPDPKSIPVI
110 120 130 140 150
SQALTKYKIT DVVMDSVIIS SMGNVMCETP TIPATIQHLF PHLLVYASNV
160 170 180 190 200
MEAFILVEKT LKKSPPPLKS FPDIQNLMSI IHRLGPKFVV LRGHHVAFDK
210 220 230 240 250
NMMITEKPDS KSWTADLIYD GKEFYIFEKP YNTTKSIHGE SCSLTAAIAS
260 270 280 290 300
NLACNIPPLQ AIHEALYSIE WAIQRVHKKS SDPYKSAQLF TALGHSSKFS
310 320
GSLISLKSEN YIPQADLTSV LLSHIPS
Length:327
Mass (Da):35,840
Last modified:May 1, 2000 - v1
Checksum:i60632515D4D9C050
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB52152.1.
PIRiT41198.
RefSeqiNP_587935.1. NM_001022926.2.

Genome annotation databases

EnsemblFungiiSPCC18B5.05c.1; SPCC18B5.05c.1:pep; SPCC18B5.05c.
GeneIDi2539014.
KEGGispo:SPCC18B5.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB52152.1.
PIRiT41198.
RefSeqiNP_587935.1. NM_001022926.2.

3D structure databases

ProteinModelPortaliQ9USL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275587. 28 interactions.
MINTiMINT-4708190.
STRINGi4896.SPCC18B5.05c.1.

Proteomic databases

MaxQBiQ9USL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC18B5.05c.1; SPCC18B5.05c.1:pep; SPCC18B5.05c.
GeneIDi2539014.
KEGGispo:SPCC18B5.05c.

Organism-specific databases

EuPathDBiFungiDB:SPCC18B5.05c.
PomBaseiSPCC18B5.05c.

Phylogenomic databases

eggNOGiCOG0351.
InParanoidiQ9USL6.
KOiK00877.
OMAiRGVYGMG.
OrthoDBiEOG75MW5D.
PhylomeDBiQ9USL6.

Enzyme and pathway databases

UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Miscellaneous databases

NextBioi20800188.
PROiQ9USL6.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYJK5_SCHPO
AccessioniPrimary (citable) accession number: Q9USL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.