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Q9USL6

- YJK5_SCHPO

UniProt

Q9USL6 - YJK5_SCHPO

Protein

Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c

Gene

SPCC18B5.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

    Catalytic activityi

    ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
    ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
    3. phosphomethylpyrimidine kinase activity Source: PomBase

    GO - Biological processi

    1. thiamine biosynthetic process Source: PomBase
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00060; UER00137.
    UPA00060; UER00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c (EC:2.7.1.49, EC:2.7.4.7)
    Alternative name(s):
    Hydroxymethylpyrimidine kinase
    Short name:
    HMP kinase
    Hydroxymethylpyrimidine phosphate kinase
    Short name:
    HMP-P kinase
    Short name:
    HMP-phosphate kinase
    Short name:
    HMPP kinase
    Gene namesi
    ORF Names:SPCC18B5.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC18B5.05c.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05cPRO_0000343140Add
    BLAST

    Proteomic databases

    MaxQBiQ9USL6.

    Interactioni

    Protein-protein interaction databases

    BioGridi275587. 27 interactions.
    MINTiMINT-4708190.
    STRINGi4896.SPCC18B5.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9USL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ThiD family.Curated

    Phylogenomic databases

    eggNOGiCOG0351.
    OMAiRGVYGMG.
    OrthoDBiEOG75MW5D.
    PhylomeDBiQ9USL6.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9USL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEANQSHNAK TNHPTCLTIA GSDCSGAAGI QADLKVMTAH QVYGMSVLTA    50
    LTCQNSHGIT GIYPLHPSLI QRQIDACLSD IQCRVVKIGM LPDPKSIPVI 100
    SQALTKYKIT DVVMDSVIIS SMGNVMCETP TIPATIQHLF PHLLVYASNV 150
    MEAFILVEKT LKKSPPPLKS FPDIQNLMSI IHRLGPKFVV LRGHHVAFDK 200
    NMMITEKPDS KSWTADLIYD GKEFYIFEKP YNTTKSIHGE SCSLTAAIAS 250
    NLACNIPPLQ AIHEALYSIE WAIQRVHKKS SDPYKSAQLF TALGHSSKFS 300
    GSLISLKSEN YIPQADLTSV LLSHIPS 327
    Length:327
    Mass (Da):35,840
    Last modified:May 1, 2000 - v1
    Checksum:i60632515D4D9C050
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB52152.1.
    PIRiT41198.
    RefSeqiNP_587935.1. NM_001022926.2.

    Genome annotation databases

    EnsemblFungiiSPCC18B5.05c.1; SPCC18B5.05c.1:pep; SPCC18B5.05c.
    GeneIDi2539014.
    KEGGispo:SPCC18B5.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB52152.1 .
    PIRi T41198.
    RefSeqi NP_587935.1. NM_001022926.2.

    3D structure databases

    ProteinModelPortali Q9USL6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275587. 27 interactions.
    MINTi MINT-4708190.
    STRINGi 4896.SPCC18B5.05c-1.

    Proteomic databases

    MaxQBi Q9USL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC18B5.05c.1 ; SPCC18B5.05c.1:pep ; SPCC18B5.05c .
    GeneIDi 2539014.
    KEGGi spo:SPCC18B5.05c.

    Organism-specific databases

    PomBasei SPCC18B5.05c.

    Phylogenomic databases

    eggNOGi COG0351.
    OMAi RGVYGMG.
    OrthoDBi EOG75MW5D.
    PhylomeDBi Q9USL6.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00137 .
    UPA00060 ; UER00138 .

    Miscellaneous databases

    NextBioi 20800188.
    PROi Q9USL6.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYJK5_SCHPO
    AccessioniPrimary (citable) accession number: Q9USL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3