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Q9USL6 (YJK5_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
ORF Names:SPCC18B5.05c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c
PRO_0000343140

Sites

Binding site541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9USL6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 60632515D4D9C050

FASTA32735,840
        10         20         30         40         50         60 
MEANQSHNAK TNHPTCLTIA GSDCSGAAGI QADLKVMTAH QVYGMSVLTA LTCQNSHGIT 

        70         80         90        100        110        120 
GIYPLHPSLI QRQIDACLSD IQCRVVKIGM LPDPKSIPVI SQALTKYKIT DVVMDSVIIS 

       130        140        150        160        170        180 
SMGNVMCETP TIPATIQHLF PHLLVYASNV MEAFILVEKT LKKSPPPLKS FPDIQNLMSI 

       190        200        210        220        230        240 
IHRLGPKFVV LRGHHVAFDK NMMITEKPDS KSWTADLIYD GKEFYIFEKP YNTTKSIHGE 

       250        260        270        280        290        300 
SCSLTAAIAS NLACNIPPLQ AIHEALYSIE WAIQRVHKKS SDPYKSAQLF TALGHSSKFS 

       310        320 
GSLISLKSEN YIPQADLTSV LLSHIPS 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAB52152.1.
PIRT41198.
RefSeqNP_587935.1. NM_001022926.2.

3D structure databases

ProteinModelPortalQ9USL6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275587. 27 interactions.
MINTMINT-4708190.
STRING4896.SPCC18B5.05c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC18B5.05c.1; SPCC18B5.05c.1:pep; SPCC18B5.05c.
GeneID2539014.
KEGGspo:SPCC18B5.05c.

Organism-specific databases

PomBaseSPCC18B5.05c.

Phylogenomic databases

eggNOGCOG0351.
OMARGVYGMG.
OrthoDBEOG75MW5D.
PhylomeDBQ9USL6.

Enzyme and pathway databases

UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

InterProIPR013749. HMP-P_kinase-1.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800188.
PROQ9USL6.

Entry information

Entry nameYJK5_SCHPO
AccessionPrimary (citable) accession number: Q9USL6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways