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Protein

Isoleucine--tRNA ligase, mitochondrial

Gene

ism1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei628ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoleucine--tRNA ligase, mitochondrial (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
Name:ism1
ORF Names:SPCC18B5.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC18B5.08c
PomBaseiSPCC18B5.08c ism1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003396541 – 973Isoleucine--tRNA ligase, mitochondrialAdd BLAST973

Proteomic databases

MaxQBiQ9USL3
PaxDbiQ9USL3
PRIDEiQ9USL3

Interactioni

Protein-protein interaction databases

STRINGi4896.SPCC18B5.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ9USL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi87 – 97"HIGH" regionBy similarityAdd BLAST11
Motifi625 – 629"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246402
InParanoidiQ9USL3
KOiK01870
OMAiHLGTAWN
OrthoDBiEOG092C0SBX
PhylomeDBiQ9USL3

Family and domain databases

CDDicd07960 Anticodon_Ia_Ile_BEm, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_02002 Ile_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR033708 Anticodon_Ile_BEm
IPR002301 Ile-tRNA-ligase
IPR023585 Ile-tRNA-ligase_type1
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00984 TRNASYNTHILE
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00392 ileS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9USL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSYISSLP KGHNHICCKQ AGRFLSSQAD LKKYSESLCL PKTSFPIKPN
60 70 80 90 100
VKGNNEKYFK SITSDLYEWQ KENLNKEDSF VLLDGPPFAN GRLHIGHALN
110 120 130 140 150
KILKDIINRW QLLKGRSVHY VPGWDCHGLP IESKAIKANA ERKSSLEIRK
160 170 180 190 200
IAKDFANSAV QEQLMMFQRM AVMGDWPSRY ITMSDKFEIA ELKVFLSLLQ
210 220 230 240 250
KDLIFRQNKP VYWSSSSRSA LAESEIEYDD NHVSTSIYFT FPVNSFSIDG
260 270 280 290 300
CEYNNVKALV WTTTPWTIPS NLALSYHPEI NYGLYQHNNS IYLMSDNLVP
310 320 330 340 350
NLDFMQGAKR LASCPSDIIS SFTYENPLLP KQSFPFLQSN YVTNDIGTGI
360 370 380 390 400
VHVAPGHGME DYLLGLENNL RPFSPLDDYG RYTKEALDGS LEGLEVLGDG
410 420 430 440 450
GKKVISIMKN QNMIVKVSPY KHRYPYDWRT HKPLILRATP QWFISLENER
460 470 480 490 500
KTAIKALDSV KMIPPNSRAR LLGFLNGRPE WCISRQRAWG LPIPVLYEKG
510 520 530 540 550
TKIPLLTVKS VSYIIEKMEV EGVDSWFNDT ENNGHAQWVH PDYRNKEYIR
560 570 580 590 600
GTETLDVWFD SGTSWTTIAP RKNKPLIDLC LEGSDQHRGW FQSLLLTYTA
610 620 630 640 650
YQSKPEAPFS TLFTHGFIFD ERGQKQSKSL GNVTDPEDVI NGKLLKGKKL
660 670 680 690 700
PYGVDLLRLW VASCDSTNDT NLGPNILTQV GESLKKWRLT SRFCLGNLHD
710 720 730 740 750
WNTSSSVDVG ELRGIDKLAL VQLDKFQTEI RELYESYSIN KVVHHLNYFM
760 770 780 790 800
NSFLSSTYFD AVKDRLYADL PNSVSRRSVQ TVLYHSLLTL IWAISPITPL
810 820 830 840 850
LAQEIWQSLP DSYLNSSYQT PFHAGETHLI SSLRSKVDLL DRKFLIKEYL
860 870 880 890 900
VLQQLKYSIN LLITAARENL TIKNSLEAYV VIKSKSQSLL SFLKNYSSDL
910 920 930 940 950
PFLFNTSKVF INEIPENLKL ASVTQPEVQL DYGVANISLF FSNQQKCLRC
960 970
WMHTAHEDGL CDRCESVLAQ LKR
Length:973
Mass (Da):111,255
Last modified:May 1, 2000 - v1
Checksum:i7061018D18A6C43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB52155.1
PIRiT41201
RefSeqiNP_587938.1, NM_001022929.2

Genome annotation databases

EnsemblFungiiSPCC18B5.08c.1; SPCC18B5.08c.1:pep; SPCC18B5.08c
GeneIDi2539323
KEGGispo:SPCC18B5.08c

Similar proteinsi

Entry informationi

Entry nameiSYIM_SCHPO
AccessioniPrimary (citable) accession number: Q9USL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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