Reviewed, UniProtKB/Swiss-Prot Q9USJ6 (FMNR_SCHPO)

Names and origin

Protein names

Recommended name:
    NAD(P)H-dependent FMN reductase C4B3.06c
      Short name=FMN reductase C4B3.06c
    EC=1.5.1.29
Alternative name(s):
    Azoreductase C4B3.06c

Gene names

ORF Names:

SPCC4B3.06c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has several reductase activities that are NAD(P)H-dependent and involve FMN as a cofactor. May be involved in ferric iron assimilation By similarity.
Catalytic activity	FMNH(2) + NAD(P)(+) = FMN + NAD(P)H.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. Nucleus.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	FMN Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Ref.2 Inferred from direct assay. Source: GeneDB_SPombe nucleus Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	NAD(P)H-dependent FMN reductase C4B3.06c		PRO_0000315910
Regions
	Region	96 – 99	4	FMN binding By similarity
Sites
	Binding site	22	1	FMN By similarity
	Binding site	126	1	FMN By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9USJ6-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D9552E192A940C98	FASTA	200	22,125
	10 20 30 40 50 60 MTLPEKLLKI TPKILVIMGS VRSKRLCPTI ATWVGEMGKR ETNFDYEKVD LTDWPLSMSD 70 80 90 100 110 120 EPGLPIMGID VYTQEHTKAW GSKIAGADGF VFVTPQYNGG YPAILKNALD HLYHEWNGKP 130 140 150 160 170 180 LLIVSYGGHG GGDCASQLKH VAGFLKMRVA PTMPALTLPR DKIVQGVVDP AVEFTKHLGE 190 200 LKKAFGEFSQ LFESNPERKP

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329672 Genomic DNA. Translation: CAB60680.1.
PIR	T50442.
RefSeq	NP_588084.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2538718.
KEGG	spo:SPCC4B3.06c.
NMPDR	fig|4896.1.peg.422.
Organism-specific databases
GeneDB_Spombe	SPCC4B3.06c.
Gene expression databases
ArrayExpress	Q9USJ6.
Family and domain databases
InterPro	IPR005025. FMN_red. [Graphical view]
Pfam	PF03358. FMN_red. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

FMNR_SCHPO

Accession

Primary (citable) accession number: Q9USJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2000
Last modified:	July 22, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)