Q9USJ6 (FMNR_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-dependent FMN reductase C4B3.06c
Short name=FMN reductase C4B3.06c
EC=1.5.1.39

Alternative name(s):
Azoreductase C4B3.06c
FMN reductase [NAD(P)H]

Gene names

ORF Names:

SPCC4B3.06c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has several reductase activities that are NAD(P)H-dependent and involve FMN as a cofactor. May be involved in ferric iron assimilation By similarity. UniProtKB Q07923
Catalytic activity	FMNH2 + NAD(P)+ = FMN + NAD(P)H. UniProtKB Q07923
Subunit structure	Homodimer By similarity. UniProtKB Q07923
Subcellular location	Cytoplasm. Nucleus Ref.2.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	FMN Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	FMN reductase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	NAD(P)H-dependent FMN reductase C4B3.06c		PRO_0000315910
Regions
	Region	96 – 99	4	FMN binding By similarity UniProtKB Q07923
Sites
	Binding site	22	1	FMN By similarity UniProtKB Q07923
	Binding site	126	1	FMN By similarity UniProtKB Q07923

Sequences

	Sequence		Length	Mass (Da)
	Q9USJ6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D9552E192A940C98	FASTA	200	22,125
	10 20 30 40 50 60 MTLPEKLLKI TPKILVIMGS VRSKRLCPTI ATWVGEMGKR ETNFDYEKVD LTDWPLSMSD 70 80 90 100 110 120 EPGLPIMGID VYTQEHTKAW GSKIAGADGF VFVTPQYNGG YPAILKNALD HLYHEWNGKP 130 140 150 160 170 180 LLIVSYGGHG GGDCASQLKH VAGFLKMRVA PTMPALTLPR DKIVQGVVDP AVEFTKHLGE 190 200 LKKAFGEFSQ LFESNPERKP

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAB60680.1.
PIR	T50442.
RefSeq	NP_588084.1. NM_001023076.1.
3D structure databases
ProteinModelPortal	Q9USJ6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC4B3.06c.1; SPCC4B3.06c.1:pep; SPCC4B3.06c.
GeneID	2538718.
KEGG	spo:SPCC4B3.06c.
NMPDR	fig|4896.1.peg.422.
Organism-specific databases
GeneDB_Spombe	SPCC4B3.06c.
Phylogenomic databases
eggNOG	fuNOG11552.
GeneTree	EFGT00050000002003.
HOGENOM	HBG697130.
OMA	EYNHSIS.
OrthoDB	EOG4DJP65.
Gene expression databases
ArrayExpress	Q9USJ6.
Family and domain databases
InterPro	IPR005025. FMN_red. [Graphical view]
Pfam	PF03358. FMN_red. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FMNR_SCHPO

Accession

Primary (citable) accession number: Q9USJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program