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Protein

Lysophospholipase NTE1

Gene

nte1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1044 – 10441By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi516 – 644129cNMP 1Add
BLAST
Nucleotide bindingi640 – 763124cNMP 2Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:SPCC4B3.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC4B3.04c.
PomBaseiSPCC4B3.04c. nte1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicBy similarityAdd
BLAST
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Topological domaini45 – 6117LumenalBy similarityAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 13161234CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13161316Lysophospholipase NTE1PRO_0000295330Add
BLAST

Proteomic databases

MaxQBiQ9USJ4.

Interactioni

Protein-protein interaction databases

MINTiMINT-4708016.
STRINGi4896.SPCC4B3.04c.1.

Structurei

3D structure databases

ProteinModelPortaliQ9USJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1011 – 1176166PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1042 – 10465GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ9USJ4.
KOiK14676.
OMAiESAHENP.
OrthoDBiEOG70W3NS.
PhylomeDBiQ9USJ4.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITDRILQN RIVSKVIFFV LRSVTLSLVS VTRFSLFLLS FATITVPKWA
60 70 80 90 100
YKIVTYSLTI QFNFKSLLFL FFVSICVVIL VVRYRYLNKY ARLPHEAPIK
110 120 130 140 150
EAKLGPDTNI RPSEPRIGFQ NYLDEFLSAI SIFGYLEKPV FVELARHIRT
160 170 180 190 200
QRVAEGNTIY LGEQSSFILV VDGCFQVFTA PEKDSAEVVE EAGQPEYRLL
210 220 230 240 250
TEVSNGAPLS SFFTVLELFT ELIPEATSKE NPFKSTTSSL RPGSSTTTEA
260 270 280 290 300
GANNASKPHM PQPKKARIIA KAKIDTTIAV IPANAFHHLV HKFPNSSAQI
310 320 330 340 350
VQVILTRFQR VTFSTGYEYL GLSDAIFSIE KNFNSLTAYE LPNYIRSDII
360 370 380 390 400
DDFKKEAMSE HLSQASNESF IVLRSKGAQS RLSNQYFSKA FDKEHGNFVS
410 420 430 440 450
DIDRSTANAG DLLSSTNPHS TLLSTSVGPL RKFPLNRSYS REVGDYDISA
460 470 480 490 500
SFRDGLLQCI FKSLGVFNYE LKEDNDDLCT ENDSSEGDSD SLKKVDFLGQ
510 520 530 540 550
IAMMSATDRE EVKSSIVVST KKSTILEFAK EIEIIFYKKG TTIVRQGDHA
560 570 580 590 600
DGLYYIIDGF LDATCPSKLT FSTSYDTDLG MHSFMIKPGG IVNYQACVSN
610 620 630 640 650
YRSFINVTAR SDVLVGFLPR SCLERIIDQE PLISLTIAKR LISLVPSLLL
660 670 680 690 700
KLDFAVGWIH LNPDQVVYEK NDPSDCVYVV LNGRLRSIED ERGSARTQVD
710 720 730 740 750
YFNEYGKGDS VGELEMLLNN RRSSTLFAIR DSELAKIPET LFNALSLSHP
760 770 780 790 800
AVGLQLSKII ANRMNLLLNN KSMDGMQHQP HEKHSIRTLA IVPSSSTGLL
810 820 830 840 850
ILFSQKLTSV LSVMGKSVKV LRQSSVLEHL GKHAFSRMGR FKLSSYLSDL
860 870 880 890 900
EDKYDILIYV ADSGVGSAWL QTCIRQADCI YILAEADQNP NIGEYEQHLI
910 920 930 940 950
AMKSTARKEL VLLHPERFCP SGLTRLWLKE RPWVYAHHHV QLRIGLDNEI
960 970 980 990 1000
SQNNEAKVFL NIIRAKVQNL HYGFRKYIDW KHLHPVYQAN RAQDSDFARL
1010 1020 1030 1040 1050
ARRICGKAIA LVLGGGGARG ISQIGILYAL EEAGIPFDII GGTSIGAFNG
1060 1070 1080 1090 1100
GLYAWEADLV PMFGRAKKFC GRMANLWRFV LDVTYPQAAY TTGHEFNRGI
1110 1120 1130 1140 1150
WKTFGEIHIE DFWLPFYANT TNITHSRMDI HSSGYAWRYI RASMSLAGLV
1160 1170 1180 1190 1200
PPMLSDSGDM LLDGGYMDNL TVSHMQSLGA SSIFAIDVGS EDSREPMHYG
1210 1220 1230 1240 1250
DTVSGVWALI SRWIPFIPKT SFPSLAEIQS RLTYVTSVAT GEKVKSMPGC
1260 1270 1280 1290 1300
FYMRPPVKDF PTLEFGSFEK IYNVGYNYGK EYVEKLKTSH KLDDILSPRD
1310
TSKRHPKFLS SRRNSL
Length:1,316
Mass (Da):147,846
Last modified:May 1, 2000 - v1
Checksum:iAF7FB587D61CC69D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB60678.1.
PIRiT50444.
RefSeqiNP_588086.1. NM_001023078.2.

Genome annotation databases

EnsemblFungiiSPCC4B3.04c.1; SPCC4B3.04c.1:pep; SPCC4B3.04c.
GeneIDi2539411.
KEGGispo:SPCC4B3.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB60678.1.
PIRiT50444.
RefSeqiNP_588086.1. NM_001023078.2.

3D structure databases

ProteinModelPortaliQ9USJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4708016.
STRINGi4896.SPCC4B3.04c.1.

Proteomic databases

MaxQBiQ9USJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC4B3.04c.1; SPCC4B3.04c.1:pep; SPCC4B3.04c.
GeneIDi2539411.
KEGGispo:SPCC4B3.04c.

Organism-specific databases

EuPathDBiFungiDB:SPCC4B3.04c.
PomBaseiSPCC4B3.04c. nte1.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ9USJ4.
KOiK14676.
OMAiESAHENP.
OrthoDBiEOG70W3NS.
PhylomeDBiQ9USJ4.

Miscellaneous databases

NextBioi20800575.
PROiQ9USJ4.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiNTE1_SCHPO
AccessioniPrimary (citable) accession number: Q9USJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.