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Q9USJ4

- NTE1_SCHPO

UniProt

Q9USJ4 - NTE1_SCHPO

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Protein
Lysophospholipase NTE1
Gene
nte1, SPCC4B3.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1044 – 10441 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi516 – 644129cNMP 1
Add
BLAST
Nucleotide bindingi640 – 763124cNMP 2
Add
BLAST

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: PomBase
  2. lysophospholipase activity Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. phosphatidylcholine catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:SPCC4B3.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC4B3.04c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Cytoplasmic By similarity
Add
BLAST
Transmembranei24 – 4421Helical; Reviewed prediction
Add
BLAST
Topological domaini45 – 6117Lumenal By similarity
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 13161234Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. endoplasmic reticulum membrane Source: PomBase
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13161316Lysophospholipase NTE1
PRO_0000295330Add
BLAST

Proteomic databases

MaxQBiQ9USJ4.

Interactioni

Protein-protein interaction databases

BioGridi275976. 1 interaction.
MINTiMINT-4708016.
STRINGi4896.SPCC4B3.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9USJ4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1011 – 1176166Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1042 – 10465GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OMAiASENDRS.
OrthoDBiEOG70W3NS.
PhylomeDBiQ9USJ4.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9USJ4-1 [UniParc]FASTAAdd to Basket

« Hide

MDITDRILQN RIVSKVIFFV LRSVTLSLVS VTRFSLFLLS FATITVPKWA     50
YKIVTYSLTI QFNFKSLLFL FFVSICVVIL VVRYRYLNKY ARLPHEAPIK 100
EAKLGPDTNI RPSEPRIGFQ NYLDEFLSAI SIFGYLEKPV FVELARHIRT 150
QRVAEGNTIY LGEQSSFILV VDGCFQVFTA PEKDSAEVVE EAGQPEYRLL 200
TEVSNGAPLS SFFTVLELFT ELIPEATSKE NPFKSTTSSL RPGSSTTTEA 250
GANNASKPHM PQPKKARIIA KAKIDTTIAV IPANAFHHLV HKFPNSSAQI 300
VQVILTRFQR VTFSTGYEYL GLSDAIFSIE KNFNSLTAYE LPNYIRSDII 350
DDFKKEAMSE HLSQASNESF IVLRSKGAQS RLSNQYFSKA FDKEHGNFVS 400
DIDRSTANAG DLLSSTNPHS TLLSTSVGPL RKFPLNRSYS REVGDYDISA 450
SFRDGLLQCI FKSLGVFNYE LKEDNDDLCT ENDSSEGDSD SLKKVDFLGQ 500
IAMMSATDRE EVKSSIVVST KKSTILEFAK EIEIIFYKKG TTIVRQGDHA 550
DGLYYIIDGF LDATCPSKLT FSTSYDTDLG MHSFMIKPGG IVNYQACVSN 600
YRSFINVTAR SDVLVGFLPR SCLERIIDQE PLISLTIAKR LISLVPSLLL 650
KLDFAVGWIH LNPDQVVYEK NDPSDCVYVV LNGRLRSIED ERGSARTQVD 700
YFNEYGKGDS VGELEMLLNN RRSSTLFAIR DSELAKIPET LFNALSLSHP 750
AVGLQLSKII ANRMNLLLNN KSMDGMQHQP HEKHSIRTLA IVPSSSTGLL 800
ILFSQKLTSV LSVMGKSVKV LRQSSVLEHL GKHAFSRMGR FKLSSYLSDL 850
EDKYDILIYV ADSGVGSAWL QTCIRQADCI YILAEADQNP NIGEYEQHLI 900
AMKSTARKEL VLLHPERFCP SGLTRLWLKE RPWVYAHHHV QLRIGLDNEI 950
SQNNEAKVFL NIIRAKVQNL HYGFRKYIDW KHLHPVYQAN RAQDSDFARL 1000
ARRICGKAIA LVLGGGGARG ISQIGILYAL EEAGIPFDII GGTSIGAFNG 1050
GLYAWEADLV PMFGRAKKFC GRMANLWRFV LDVTYPQAAY TTGHEFNRGI 1100
WKTFGEIHIE DFWLPFYANT TNITHSRMDI HSSGYAWRYI RASMSLAGLV 1150
PPMLSDSGDM LLDGGYMDNL TVSHMQSLGA SSIFAIDVGS EDSREPMHYG 1200
DTVSGVWALI SRWIPFIPKT SFPSLAEIQS RLTYVTSVAT GEKVKSMPGC 1250
FYMRPPVKDF PTLEFGSFEK IYNVGYNYGK EYVEKLKTSH KLDDILSPRD 1300
TSKRHPKFLS SRRNSL 1316
Length:1,316
Mass (Da):147,846
Last modified:May 1, 2000 - v1
Checksum:iAF7FB587D61CC69D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB60678.1.
PIRiT50444.
RefSeqiNP_588086.1. NM_001023078.2.

Genome annotation databases

EnsemblFungiiSPCC4B3.04c.1; SPCC4B3.04c.1:pep; SPCC4B3.04c.
GeneIDi2539411.
KEGGispo:SPCC4B3.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB60678.1 .
PIRi T50444.
RefSeqi NP_588086.1. NM_001023078.2.

3D structure databases

ProteinModelPortali Q9USJ4.
ModBasei Search...

Protein-protein interaction databases

BioGridi 275976. 1 interaction.
MINTi MINT-4708016.
STRINGi 4896.SPCC4B3.04c-1.

Proteomic databases

MaxQBi Q9USJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC4B3.04c.1 ; SPCC4B3.04c.1:pep ; SPCC4B3.04c .
GeneIDi 2539411.
KEGGi spo:SPCC4B3.04c.

Organism-specific databases

PomBasei SPCC4B3.04c.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OMAi ASENDRS.
OrthoDBi EOG70W3NS.
PhylomeDBi Q9USJ4.

Miscellaneous databases

NextBioi 20800575.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiNTE1_SCHPO
AccessioniPrimary (citable) accession number: Q9USJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi