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Q9USJ4 (NTE1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:SPCC4B3.04c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13161316Lysophospholipase NTE1
PRO_0000295330

Regions

Topological domain1 – 2323Cytoplasmic By similarity
Transmembrane24 – 4421Helical; Potential
Topological domain45 – 6117Lumenal By similarity
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 13161234Cytoplasmic By similarity
Domain1011 – 1176166Patatin
Nucleotide binding516 – 644129cNMP 1
Nucleotide binding640 – 763124cNMP 2
Motif1042 – 10465GXSXG

Sites

Active site10441 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9USJ4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: AF7FB587D61CC69D

FASTA1,316147,846
        10         20         30         40         50         60 
MDITDRILQN RIVSKVIFFV LRSVTLSLVS VTRFSLFLLS FATITVPKWA YKIVTYSLTI 

        70         80         90        100        110        120 
QFNFKSLLFL FFVSICVVIL VVRYRYLNKY ARLPHEAPIK EAKLGPDTNI RPSEPRIGFQ 

       130        140        150        160        170        180 
NYLDEFLSAI SIFGYLEKPV FVELARHIRT QRVAEGNTIY LGEQSSFILV VDGCFQVFTA 

       190        200        210        220        230        240 
PEKDSAEVVE EAGQPEYRLL TEVSNGAPLS SFFTVLELFT ELIPEATSKE NPFKSTTSSL 

       250        260        270        280        290        300 
RPGSSTTTEA GANNASKPHM PQPKKARIIA KAKIDTTIAV IPANAFHHLV HKFPNSSAQI 

       310        320        330        340        350        360 
VQVILTRFQR VTFSTGYEYL GLSDAIFSIE KNFNSLTAYE LPNYIRSDII DDFKKEAMSE 

       370        380        390        400        410        420 
HLSQASNESF IVLRSKGAQS RLSNQYFSKA FDKEHGNFVS DIDRSTANAG DLLSSTNPHS 

       430        440        450        460        470        480 
TLLSTSVGPL RKFPLNRSYS REVGDYDISA SFRDGLLQCI FKSLGVFNYE LKEDNDDLCT 

       490        500        510        520        530        540 
ENDSSEGDSD SLKKVDFLGQ IAMMSATDRE EVKSSIVVST KKSTILEFAK EIEIIFYKKG 

       550        560        570        580        590        600 
TTIVRQGDHA DGLYYIIDGF LDATCPSKLT FSTSYDTDLG MHSFMIKPGG IVNYQACVSN 

       610        620        630        640        650        660 
YRSFINVTAR SDVLVGFLPR SCLERIIDQE PLISLTIAKR LISLVPSLLL KLDFAVGWIH 

       670        680        690        700        710        720 
LNPDQVVYEK NDPSDCVYVV LNGRLRSIED ERGSARTQVD YFNEYGKGDS VGELEMLLNN 

       730        740        750        760        770        780 
RRSSTLFAIR DSELAKIPET LFNALSLSHP AVGLQLSKII ANRMNLLLNN KSMDGMQHQP 

       790        800        810        820        830        840 
HEKHSIRTLA IVPSSSTGLL ILFSQKLTSV LSVMGKSVKV LRQSSVLEHL GKHAFSRMGR 

       850        860        870        880        890        900 
FKLSSYLSDL EDKYDILIYV ADSGVGSAWL QTCIRQADCI YILAEADQNP NIGEYEQHLI 

       910        920        930        940        950        960 
AMKSTARKEL VLLHPERFCP SGLTRLWLKE RPWVYAHHHV QLRIGLDNEI SQNNEAKVFL 

       970        980        990       1000       1010       1020 
NIIRAKVQNL HYGFRKYIDW KHLHPVYQAN RAQDSDFARL ARRICGKAIA LVLGGGGARG 

      1030       1040       1050       1060       1070       1080 
ISQIGILYAL EEAGIPFDII GGTSIGAFNG GLYAWEADLV PMFGRAKKFC GRMANLWRFV 

      1090       1100       1110       1120       1130       1140 
LDVTYPQAAY TTGHEFNRGI WKTFGEIHIE DFWLPFYANT TNITHSRMDI HSSGYAWRYI 

      1150       1160       1170       1180       1190       1200 
RASMSLAGLV PPMLSDSGDM LLDGGYMDNL TVSHMQSLGA SSIFAIDVGS EDSREPMHYG 

      1210       1220       1230       1240       1250       1260 
DTVSGVWALI SRWIPFIPKT SFPSLAEIQS RLTYVTSVAT GEKVKSMPGC FYMRPPVKDF 

      1270       1280       1290       1300       1310 
PTLEFGSFEK IYNVGYNYGK EYVEKLKTSH KLDDILSPRD TSKRHPKFLS SRRNSL 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAB60678.1.
PIRT50444.
RefSeqNP_588086.1. NM_001023078.2.

3D structure databases

ProteinModelPortalQ9USJ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275976. 1 interaction.
MINTMINT-4708016.
STRING4896.SPCC4B3.04c-1.

Proteomic databases

MaxQBQ9USJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC4B3.04c.1; SPCC4B3.04c.1:pep; SPCC4B3.04c.
GeneID2539411.
KEGGspo:SPCC4B3.04c.

Organism-specific databases

PomBaseSPCC4B3.04c.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OMAASENDRS.
OrthoDBEOG70W3NS.
PhylomeDBQ9USJ4.

Family and domain databases

Gene3D2.60.120.10. 4 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800575.

Entry information

Entry nameNTE1_SCHPO
AccessionPrimary (citable) accession number: Q9USJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names