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Q9USJ4

- NTE1_SCHPO

UniProt

Q9USJ4 - NTE1_SCHPO

Protein

Lysophospholipase NTE1

Gene

nte1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1044 – 10441By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi516 – 644129cNMP 1Add
    BLAST
    Nucleotide bindingi640 – 763124cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. carboxylic ester hydrolase activity Source: PomBase
    2. lysophospholipase activity Source: PomBase

    GO - Biological processi

    1. phosphatidylcholine catabolic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:SPCC4B3.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC4B3.04c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. endoplasmic reticulum membrane Source: PomBase
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13161316Lysophospholipase NTE1PRO_0000295330Add
    BLAST

    Proteomic databases

    MaxQBiQ9USJ4.

    Interactioni

    Protein-protein interaction databases

    BioGridi275976. 1 interaction.
    MINTiMINT-4708016.
    STRINGi4896.SPCC4B3.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9USJ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicBy similarityAdd
    BLAST
    Topological domaini45 – 6117LumenalBy similarityAdd
    BLAST
    Topological domaini83 – 13161234CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1011 – 1176166PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1042 – 10465GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OMAiASENDRS.
    OrthoDBiEOG70W3NS.
    PhylomeDBiQ9USJ4.

    Family and domain databases

    Gene3Di2.60.120.10. 4 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
    PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9USJ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDITDRILQN RIVSKVIFFV LRSVTLSLVS VTRFSLFLLS FATITVPKWA     50
    YKIVTYSLTI QFNFKSLLFL FFVSICVVIL VVRYRYLNKY ARLPHEAPIK 100
    EAKLGPDTNI RPSEPRIGFQ NYLDEFLSAI SIFGYLEKPV FVELARHIRT 150
    QRVAEGNTIY LGEQSSFILV VDGCFQVFTA PEKDSAEVVE EAGQPEYRLL 200
    TEVSNGAPLS SFFTVLELFT ELIPEATSKE NPFKSTTSSL RPGSSTTTEA 250
    GANNASKPHM PQPKKARIIA KAKIDTTIAV IPANAFHHLV HKFPNSSAQI 300
    VQVILTRFQR VTFSTGYEYL GLSDAIFSIE KNFNSLTAYE LPNYIRSDII 350
    DDFKKEAMSE HLSQASNESF IVLRSKGAQS RLSNQYFSKA FDKEHGNFVS 400
    DIDRSTANAG DLLSSTNPHS TLLSTSVGPL RKFPLNRSYS REVGDYDISA 450
    SFRDGLLQCI FKSLGVFNYE LKEDNDDLCT ENDSSEGDSD SLKKVDFLGQ 500
    IAMMSATDRE EVKSSIVVST KKSTILEFAK EIEIIFYKKG TTIVRQGDHA 550
    DGLYYIIDGF LDATCPSKLT FSTSYDTDLG MHSFMIKPGG IVNYQACVSN 600
    YRSFINVTAR SDVLVGFLPR SCLERIIDQE PLISLTIAKR LISLVPSLLL 650
    KLDFAVGWIH LNPDQVVYEK NDPSDCVYVV LNGRLRSIED ERGSARTQVD 700
    YFNEYGKGDS VGELEMLLNN RRSSTLFAIR DSELAKIPET LFNALSLSHP 750
    AVGLQLSKII ANRMNLLLNN KSMDGMQHQP HEKHSIRTLA IVPSSSTGLL 800
    ILFSQKLTSV LSVMGKSVKV LRQSSVLEHL GKHAFSRMGR FKLSSYLSDL 850
    EDKYDILIYV ADSGVGSAWL QTCIRQADCI YILAEADQNP NIGEYEQHLI 900
    AMKSTARKEL VLLHPERFCP SGLTRLWLKE RPWVYAHHHV QLRIGLDNEI 950
    SQNNEAKVFL NIIRAKVQNL HYGFRKYIDW KHLHPVYQAN RAQDSDFARL 1000
    ARRICGKAIA LVLGGGGARG ISQIGILYAL EEAGIPFDII GGTSIGAFNG 1050
    GLYAWEADLV PMFGRAKKFC GRMANLWRFV LDVTYPQAAY TTGHEFNRGI 1100
    WKTFGEIHIE DFWLPFYANT TNITHSRMDI HSSGYAWRYI RASMSLAGLV 1150
    PPMLSDSGDM LLDGGYMDNL TVSHMQSLGA SSIFAIDVGS EDSREPMHYG 1200
    DTVSGVWALI SRWIPFIPKT SFPSLAEIQS RLTYVTSVAT GEKVKSMPGC 1250
    FYMRPPVKDF PTLEFGSFEK IYNVGYNYGK EYVEKLKTSH KLDDILSPRD 1300
    TSKRHPKFLS SRRNSL 1316
    Length:1,316
    Mass (Da):147,846
    Last modified:May 1, 2000 - v1
    Checksum:iAF7FB587D61CC69D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB60678.1.
    PIRiT50444.
    RefSeqiNP_588086.1. NM_001023078.2.

    Genome annotation databases

    EnsemblFungiiSPCC4B3.04c.1; SPCC4B3.04c.1:pep; SPCC4B3.04c.
    GeneIDi2539411.
    KEGGispo:SPCC4B3.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB60678.1 .
    PIRi T50444.
    RefSeqi NP_588086.1. NM_001023078.2.

    3D structure databases

    ProteinModelPortali Q9USJ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275976. 1 interaction.
    MINTi MINT-4708016.
    STRINGi 4896.SPCC4B3.04c-1.

    Proteomic databases

    MaxQBi Q9USJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC4B3.04c.1 ; SPCC4B3.04c.1:pep ; SPCC4B3.04c .
    GeneIDi 2539411.
    KEGGi spo:SPCC4B3.04c.

    Organism-specific databases

    PomBasei SPCC4B3.04c.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OMAi ASENDRS.
    OrthoDBi EOG70W3NS.
    PhylomeDBi Q9USJ4.

    Miscellaneous databases

    NextBioi 20800575.

    Family and domain databases

    Gene3Di 2.60.120.10. 4 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
    PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiNTE1_SCHPO
    AccessioniPrimary (citable) accession number: Q9USJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3