Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-alpha-acetyltransferase 40

Gene

naa40

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A.By similarity

Catalytic activityi

Acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-N(alpha)-acetyl-L-seryl-[histone H4] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal-N(alpha)-acetyl-L-seryl-[histone H2A] + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64SubstrateBy similarity1
Binding sitei118SubstrateBy similarity1
Sitei119Essential for catalytic activityBy similarity1
Binding sitei154SubstrateBy similarity1
Binding sitei159Acetyl-CoA1 PublicationImported1
Binding sitei176SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 40Imported (EC:2.3.1.257By similarity)
Gene namesi
Name:naa40Imported
ORF Names:SPCC825.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC825.04c
PomBaseiSPCC825.04c naa40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003102991 – 204N-alpha-acetyltransferase 40Add BLAST204

Proteomic databases

MaxQBiQ9USH6
PaxDbiQ9USH6
PRIDEiQ9USH6

Interactioni

Protein-protein interaction databases

BioGridi276011, 10 interactors
STRINGi4896.SPCC825.04c.1

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 32Combined sources5
Turni33 – 35Combined sources3
Beta strandi36 – 43Combined sources8
Helixi46 – 66Combined sources21
Helixi73 – 80Combined sources8
Beta strandi86 – 92Combined sources7
Turni93 – 95Combined sources3
Beta strandi98 – 109Combined sources12
Beta strandi112 – 122Combined sources11
Helixi124 – 126Combined sources3
Helixi131 – 145Combined sources15
Beta strandi150 – 156Combined sources7
Helixi160 – 168Combined sources9
Beta strandi192 – 199Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UA3X-ray1.85A/B13-204[»]
ProteinModelPortaliQ9USH6
SMRiQ9USH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 202N-acetyltransferasePROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 109Substrate bindingBy similarity3
Regioni120 – 122Acetyl-CoA binding1 PublicationImported3
Regioni128 – 133Acetyl-CoA binding1 PublicationImported6

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9USH6
KOiK20794
OMAiEAVVYCY
OrthoDBiEOG092C55DH
PhylomeDBiQ9USH6

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9USH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFLKQYLFY SPRRMKTQEI KNVTLEDVDF LKNLGVWVEI YHHLEKGLLQ
60 70 80 90 100
QCFNLVKKNM EALYRQSSFG WDDSEKLKEM EMEKLEYICI FEKTSKKLVG
110 120 130 140 150
FLSFEDTVEA GLTCLYIYEI QLDEHIRGRN VGKWLLKNAS ILAYRRNLKY
160 170 180 190 200
IFLTVFSANL NALNFYHHFD FVPHESSPQE KKFRSGKVIH PDYYILYTKS

RKDW
Length:204
Mass (Da):24,561
Last modified:May 1, 2000 - v1
Checksum:i31465DC4BC2B151B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB58412.1
PIRiT41625
RefSeqiNP_588054.1, NM_001023046.2

Genome annotation databases

EnsemblFungiiSPCC825.04c.1; SPCC825.04c.1:pep; SPCC825.04c
GeneIDi2539448
KEGGispo:SPCC825.04c

Entry informationi

Entry nameiNAA40_SCHPO
AccessioniPrimary (citable) accession number: Q9USH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health