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Protein

Kinesin-like protein 3

Gene

klp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytoplasmic motor that could play a role in Golgi membrane recycling.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 91ATPPROSITE-ProRule annotation8
Nucleotide bindingi233 – 240ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cytoskeleton-dependent intracellular transport Source: GO_Central
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • exocytosis Source: PomBase
  • microtubule-based movement Source: GO_Central
  • protein localization Source: GO_Central
  • retrograde transport, vesicle recycling within Golgi Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 3
Alternative name(s):
Kinesin-related protein 1
Gene namesi
Name:klp3
Synonyms:krp1
ORF Names:SPAC1834.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1834.07.
PomBaseiSPAC1834.07. klp3.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: PomBase
  • cytoplasmic microtubule Source: CACAO
  • kinesin complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253871 – 554Kinesin-like protein 3Add BLAST554

Proteomic databases

MaxQBiQ9US60.
PRIDEiQ9US60.

Interactioni

Protein-protein interaction databases

BioGridi278670. 19 interactors.
MINTiMINT-4707820.

Structurei

3D structure databases

ProteinModelPortaliQ9US60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 325Kinesin motorPROSITE-ProRule annotationAdd BLAST323

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili446 – 473Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ9US60.
OMAiNDRDEST.
OrthoDBiEOG092C2D4G.
PhylomeDBiQ9US60.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9US60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIKVVCRI RPTNQLEQDL GGNNVIYPLN DSTVHIETSD YSGNFVFDRV
60 70 80 90 100
FHPSSTQNDI FSYSIESTVD DLFLGYNGTV LAYGQTGSGK TYTMMGIENN
110 120 130 140 150
FEKEGMTPRM LRRIFDKIRD SPSTTEYEVK VSYMEIYMEK IHDLLSEKND
160 170 180 190 200
RLTVHEDKLQ GVYVQGLKTI YVSSETEALD ILNKGMGSRA VASTSMNAQS
210 220 230 240 250
SRSHSIFVLE VVQTDTESGE TRRGRLFLVD LAGSESVGKS GAVGQTLEEA
260 270 280 290 300
KKINRSLSTL GMVINSLTDS KLSHVPYRDS KLTRILKESL GGNSRTTLII
310 320 330 340 350
NCSPDSYNAT ETLSTLRFGH RAKSIKNKAV VNSELSVDEM KRQLYIYKDA
360 370 380 390 400
LSRCVCGARI NNNLDYNNCH SNVWSGEHSL TLSNLAEKSN LKEAEIIQGN
410 420 430 440 450
RTIQESNNDR DESTVASIHR HNFDSDSINR LYAEAQLELK QRDGVLSSTK
460 470 480 490 500
QQLSDLMTAL GDAQERYVEL VKNHRVNSNL TANNSLNDKP GFTIEQKDKN
510 520 530 540 550
FSINNERNNF LQKLSTLDSS LAALVNVQRK LIKALISKER PQNGTVIKKI

QGGT
Length:554
Mass (Da):61,938
Last modified:May 1, 2000 - v1
Checksum:iB4533BD095C49CBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57Q → L in AAF14525 (PubMed:10641037).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154055 mRNA. Translation: AAF14525.1.
AF156966 mRNA. Translation: AAF22609.1.
AF247188 Genomic DNA. Translation: AAF81205.1.
CU329670 Genomic DNA. Translation: CAB75775.1.
PIRiT50118.
RefSeqiNP_594686.1. NM_001020115.2.

Genome annotation databases

EnsemblFungiiSPAC1834.07.1; SPAC1834.07.1:pep; SPAC1834.07.
GeneIDi2542195.
KEGGispo:SPAC1834.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154055 mRNA. Translation: AAF14525.1.
AF156966 mRNA. Translation: AAF22609.1.
AF247188 Genomic DNA. Translation: AAF81205.1.
CU329670 Genomic DNA. Translation: CAB75775.1.
PIRiT50118.
RefSeqiNP_594686.1. NM_001020115.2.

3D structure databases

ProteinModelPortaliQ9US60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278670. 19 interactors.
MINTiMINT-4707820.

Proteomic databases

MaxQBiQ9US60.
PRIDEiQ9US60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1834.07.1; SPAC1834.07.1:pep; SPAC1834.07.
GeneIDi2542195.
KEGGispo:SPAC1834.07.

Organism-specific databases

EuPathDBiFungiDB:SPAC1834.07.
PomBaseiSPAC1834.07. klp3.

Phylogenomic databases

InParanoidiQ9US60.
OMAiNDRDEST.
OrthoDBiEOG092C2D4G.
PhylomeDBiQ9US60.

Miscellaneous databases

PROiQ9US60.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLP3_SCHPO
AccessioniPrimary (citable) accession number: Q9US60
Secondary accession number(s): Q9US61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.