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Protein

Putative succinate-semialdehyde dehydrogenase C1002.12c [NADP(+)]

Gene

SPAC1002.12c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei318PROSITE-ProRule annotation1
Active sitei352PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi296 – 301NAD or NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-SPO-916853. Degradation of GABA.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative succinate-semialdehyde dehydrogenase C1002.12c [NADP(+)] (EC:1.2.1.16)
Short name:
SSDH
Gene namesi
ORF Names:SPAC1002.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1002.12c.
PomBaseiSPAC1002.12c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003103511 – 547Putative succinate-semialdehyde dehydrogenase C1002.12c [NADP(+)]Add BLAST547

Proteomic databases

MaxQBiQ9US47.
PaxDbiQ9US47.
PRIDEiQ9US47.

Interactioni

Protein-protein interaction databases

BioGridi279695. 10 interactors.
STRINGi4896.SPAC1002.12c.1.

Structurei

3D structure databases

SMRiQ9US47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000271509.
InParanoidiQ9US47.
KOiK00135.
OMAiYNVIPCS.
OrthoDBiEOG092C1LLH.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiView protein in PROSITE
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9US47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLIQSIPR YIYESNSLPK LIRSGLDRKS PIGLSLLKRN CRNRSFAANM
60 70 80 90 100
STSSKLSTNI KDLSLFDLEE FPARSYIGGK WVTAASGKTF DVENPGLNET
110 120 130 140 150
LAPVTDMSVE ETRKAIKVAH EAFLSYRNSD IKERYAILRR WYDLIMENAD
160 170 180 190 200
DLATMMTLEN GKALGDAKGE VVYAAKFIDW FAGEALRISG DSSMSSNPQN
210 220 230 240 250
RIITIKQPVG VVGIITPWNF PAAMITRKVG AALAAGCTVV IRPAAETPFT
260 270 280 290 300
ALALAKLAER AGVPAGVLNM VTANSPSEHG IELTTNPLIR KVSFTGSTNV
310 320 330 340 350
GKILAKQSSS TLKKLSLELG GNAPFIVFED ADLEKAADAL MACKFRGSGQ
360 370 380 390 400
TCVCANRIYV HSSVYDAFVD LVTERVSKFK LGYGLDAGVT HGPLISEKAI
410 420 430 440 450
SKVKQHVEDA VQKGGVVVTG GKVASNLGPM YFEPTVIINA KQGMLISEEE
460 470 480 490 500
TFGPVGALFK FDTEDEVVAW ANDSPVGLAG YLFSKDISRV FRVGEALQVG
510 520 530 540
MVGCNTGLVS DVLSPFGGVK ESGFGREGSK YGISEYLDIK SLTISTL
Length:547
Mass (Da):58,834
Last modified:June 13, 2012 - v2
Checksum:i8AD9B9A48C768252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB65612.2.
RefSeqiNP_593499.2. NM_001018933.2.

Genome annotation databases

EnsemblFungiiSPAC1002.12c.1; SPAC1002.12c.1:pep; SPAC1002.12c.
GeneIDi2543267.
KEGGispo:SPAC1002.12c.

Similar proteinsi

Entry informationi

Entry nameiSSDH1_SCHPO
AccessioniPrimary (citable) accession number: Q9US47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 13, 2012
Last modified: February 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome