Reviewed, UniProtKB/Swiss-Prot Q9US47 (SSDH1_SCHPO)

Names and origin

Protein names

Recommended name:
    Putative succinate-semialdehyde dehydrogenase C1002.12c [NADP+]
      Short name=SSDH
    EC=1.2.1.16

Gene names

ORF Names:

SPAC1002.12c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Subcellular location	Cytoplasm. Ref.2
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Putative succinate-semialdehyde dehydrogenase C1002.12c [NADP+]		PRO_0000310351
Regions
	Nucleotide binding	247 – 252	6	NAD or NADP By similarity
Sites
	Active site	269	1	By similarity
	Active site	303	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9US47-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C43A5114E401EB1E	FASTA	498	53,272
	10 20 30 40 50 60 MSTSSKLSTN IKDLSLFDLE EFPARSYIGG KWVTAASGKT FDVENPGLNE TLAPVTDMSV 70 80 90 100 110 120 EETRKAIKVA HEAFLSYRNS DIKERYAILR RWYDLIMENA DDLATMMTLE NGKALGDAKG 130 140 150 160 170 180 EVVYAAKFID WFAGEALRIS GDSSMSSNPQ NRIITIKQPV GVVGIITPWN FPAAMITRKV 190 200 210 220 230 240 GAALAAGCTV VIRPAAETPF TALALAKLAE RAGVPAGVLN MVTANSPSEH GIELTTNPLI 250 260 270 280 290 300 RKVSFTGSTN VGKILAKQSS STLKKLSLEL GGNAPFIVFE DADLEKAADA LMACKFRGSG 310 320 330 340 350 360 QTCVCANRIY VHSSVYDAFV DLVTERVSKF KLGYGLDAGV THGPLISEKA ISKVKQHVED 370 380 390 400 410 420 AVQKGGVVVT GGKVASNLGP MYFEPTVIIN AKQGMLISEE ETFGPVGALF KFDTEDEVVA 430 440 450 460 470 480 WANDSPVGLA GYLFSKDISR VFRVGEALQV GMVGCNTGLV SDVLSPFGGV KESGFGREGS 490 KYGISEYLDI KSLTISTL

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB65612.1.
RefSeq	NP_593499.1.
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Genome annotation databases
GeneID	2543267.
KEGG	spo:SPAC1002.12c.
NMPDR	fig|4896.1.peg.3469.
Organism-specific databases
GeneDB_Spombe	SPAC1002.12c.
Phylogenomic databases
OMA	Q9US47. GILTPWN.
Enzyme and pathway databases
BRENDA	1.2.1.16. 653.
Gene expression databases
ArrayExpress	Q9US47.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR010102. Succ_semiAld_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01780. SSADH. 1 hit.
PROSITE	PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSDH1_SCHPO

Accession

Primary (citable) accession number: Q9US47

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)