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Protein

D-serine dehydratase

Gene

SPAC1039.06

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts specifically D-serine to pyruvate and ammonia. May play a role in D-serine detoxification (By similarity).By similarity

Catalytic activityi

D-serine = pyruvate + NH3.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-serine dehydratase (EC:4.3.1.18)
Alternative name(s):
D-serine deaminase
Short name:
DSD
Gene namesi
ORF Names:SPAC1039.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1039.06.
PomBaseiSPAC1039.06.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170931 – 415D-serine dehydrataseAdd BLAST415

Proteomic databases

MaxQBiQ9US35.
PRIDEiQ9US35.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi279434. 3 interactors.
MINTiMINT-4707608.

Structurei

3D structure databases

ProteinModelPortaliQ9US35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DSD1 family.Curated

Phylogenomic databases

HOGENOMiHOG000171043.
InParanoidiQ9US35.
KOiK20498.
OMAiIDCDGHR.
OrthoDBiEOG092C25II.
PhylomeDBiQ9US35.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR026956. D-ser_dehydrat-like_dom.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF01168. Ala_racemase_N. 1 hit.
PF14031. D-ser_dehydrat. 1 hit.
[Graphical view]
SMARTiSM01119. D-ser_dehydrat. 1 hit.
[Graphical view]
SUPFAMiSSF51419. SSF51419. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9US35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNVDKFSS RFYLNVNKEE LKKEYVGKTI QQVPTPGFVI DEAIFEKNCN
60 70 80 90 100
RMLDRASDIG VTFRAHVKTH KTIEGTLLQL GDGRTKAVVV STLMEGFSLI
110 120 130 140 150
PLILEGKIDD LLYGLPVAKS RLPELYELSK IVPHLRLMID NPKQLDILRE
160 170 180 190 200
FTSTLPDDAK PWSIFVKIDM GTHRAGVTND SQVVKDLIST ILSDKSLFDL
210 220 230 240 250
FGFYCHAGHS YASRSIDAAS EFLCAEIDAA NTAAKFATSI DPSLKLTLSV
260 270 280 290 300
GATPTAHSVS PKVKELLPTL SGKLEVHAGN YPMNDVQQMI TKCISQADVA
310 320 330 340 350
DYVFAEVISN YPGRNGEPGE VLVNAGVIAM SRETSPEGDF GIVITPGFES
360 370 380 390 400
FYVDRLSQEH GILKSKDPKA TLPDASQVLC IIPNHSCITA AAFPWYYITK
410
GSDVITDIWV PWKGW
Length:415
Mass (Da):45,647
Last modified:May 1, 2000 - v1
Checksum:i31234FC8BFDFBAC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB63542.1.
PIRiT50056.
RefSeqiNP_594997.1. NM_001020428.2.

Genome annotation databases

EnsemblFungiiSPAC1039.06.1; SPAC1039.06.1:pep; SPAC1039.06.
GeneIDi2542996.
KEGGispo:SPAC1039.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB63542.1.
PIRiT50056.
RefSeqiNP_594997.1. NM_001020428.2.

3D structure databases

ProteinModelPortaliQ9US35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279434. 3 interactors.
MINTiMINT-4707608.

Proteomic databases

MaxQBiQ9US35.
PRIDEiQ9US35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1039.06.1; SPAC1039.06.1:pep; SPAC1039.06.
GeneIDi2542996.
KEGGispo:SPAC1039.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC1039.06.
PomBaseiSPAC1039.06.

Phylogenomic databases

HOGENOMiHOG000171043.
InParanoidiQ9US35.
KOiK20498.
OMAiIDCDGHR.
OrthoDBiEOG092C25II.
PhylomeDBiQ9US35.

Miscellaneous databases

PROiQ9US35.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR026956. D-ser_dehydrat-like_dom.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF01168. Ala_racemase_N. 1 hit.
PF14031. D-ser_dehydrat. 1 hit.
[Graphical view]
SMARTiSM01119. D-ser_dehydrat. 1 hit.
[Graphical view]
SUPFAMiSSF51419. SSF51419. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDSD1_SCHPO
AccessioniPrimary (citable) accession number: Q9US35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.