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Protein

Chromodomain helicase hrp1

Gene

hrp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play a role in mitotic chromosome segregation and maintenance of chromatin structure. Has ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi415 – 422ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: PomBase
  • chromatin-mediated maintenance of transcription Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at centromere outer repeat region Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • negative regulation of histone acetylation Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of nucleosome density Source: PomBase
  • termination of RNA polymerase II transcription Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain helicase hrp1 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase hrp1
Gene namesi
Name:hrp1
ORF Names:SPAC1783.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1783.05.
PomBaseiSPAC1783.05. hrp1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric outer repeat region Source: GOC
  • condensed nuclear chromosome, centromeric region Source: PomBase
  • mediator complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802411 – 1373Chromodomain helicase hrp1Add BLAST1373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142Phosphoserine1 Publication1
Modified residuei145Phosphoserine1 Publication1
Modified residuei1259Phosphothreonine1 Publication1
Modified residuei1260Phosphoserine1 Publication1
Modified residuei1264Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9US25.
PRIDEiQ9US25.

PTM databases

iPTMnetiQ9US25.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SPCC364.06O597972EBI-7414005,EBI-7414085

Protein-protein interaction databases

BioGridi278827. 73 interactors.
IntActiQ9US25. 7 interactors.
MINTiMINT-4979817.

Structurei

3D structure databases

ProteinModelPortaliQ9US25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 276Chromo 1PROSITE-ProRule annotationAdd BLAST74
Domaini304 – 365Chromo 2PROSITE-ProRule annotationAdd BLAST62
Domaini402 – 573Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST172
Domaini708 – 869Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi524 – 527DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 199Poly-Glu9
Compositional biasi955 – 980Glu-richAdd BLAST26

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 2 chromo domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000207917.
InParanoidiQ9US25.
KOiK11367.
OMAiGIKRVDN.
OrthoDBiEOG092C1YH4.
PhylomeDBiQ9US25.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR009057. Homeodomain-like.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9US25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEHSNYDL KNHPTSVQES TLNGSAVTDP QFGNTTNSLP SMNGLLNHEN
60 70 80 90 100
SFASQQSLSS SAFDDSEIVT STANSTVVSS ALSTPKIDDA QNSDDVRVDG
110 120 130 140 150
TRRSSRAKRP VYRDFSYTEI DEHEIPIPKK RKSKPAPKQK KSVASDDEDA
160 170 180 190 200
YDKRHRFSIN SASGTEIRTS LRSSKGKSVN YNEQEFYDDF EDEEEEVEEQ
210 220 230 240 250
VEEEYEPIID FVLNHRKRAD AQDDDPKSSY QYLIKWQEVS HLHNTWEDYS
260 270 280 290 300
TLSSVRGYKK VDNYIKQNII YDREIREDPT TTFEDIEALD IERERKNMLF
310 320 330 340 350
EEYKIVERIV ASETNEEGKT EYFVKWRQLP YDNCTWEDAD VIYSMAPNEV
360 370 380 390 400
YQFLQRENSP YLPYKGVFYN TRPPYRKLEK QPSYIKGGEI RDFQLTGINW
410 420 430 440 450
MAYLWHRNEN GILADEMGLG KTVQTVCFLS YLVHSLKQHG PFLIVVPLST
460 470 480 490 500
VPAWQETLAN WTPDLNSICY TGNTESRANI REYEFYLSTN SRKLKFNILL
510 520 530 540 550
TTYEYILKDK QELNNIRWQY LAIDEAHRLK NSESSLYETL SQFRTANRLL
560 570 580 590 600
ITGTPLQNNL KELASLVNFL MPGKFYIRDE LNFDQPNAEQ ERDIRDLQER
610 620 630 640 650
LQPFILRRLK KDVEKSLPSK SERILRVELS DMQTEWYKNI LTKNYRALTG
660 670 680 690 700
HTDGRGQLSL LNIVVELKKV SNHPYLFPGA AEKWMMGRKM TREDTLRGII
710 720 730 740 750
MNSGKMVLLD KLLQRLKHDG HRVLIFSQMV RMLNILGEYM SLRGYNYQRL
760 770 780 790 800
DGTIPASVRR VSIDHFNAPD SPDFVFLLST RAGGLGINLN TADTVIIFDS
810 820 830 840 850
DWNPQADLQA MARAHRIGQK NHVNVYRFLS KDTVEEDILE RARRKMILEY
860 870 880 890 900
AIISLGVTEK SKNSKNDKYD AQELSAILKF GASNMFKATE NQKKLENMNL
910 920 930 940 950
DDILSHAEDR DSSNDVGGAS MGGEEFLKQF EVTDYKAEDL NWDDIIPEEE
960 970 980 990 1000
MERIEEEERM LAAQRAKEEE RERREEEERE NDEDHPSRTY KRTTKSITKR
1010 1020 1030 1040 1050
QQRREEMVRE KEIRLLYRAM IKFGLVDERF DTIVKEAELQ ATDPKRIYSL
1060 1070 1080 1090 1100
SADMVKACDE AVERLGADDT KNKQPRKAIL IEFKGVKNIN AETVTLRVKD
1110 1120 1130 1140 1150
LTHLHRAYKG LDPLKQIIGY PIRSVHSWNC SWGIKEDSML LAGINKHGFG
1160 1170 1180 1190 1200
CWQAIKNDPD LGLHDKIFLD EAKNDKESRY VPSAVHLVRR GEYLLSVVRE
1210 1220 1230 1240 1250
HPDLFVVKTD QPTKRKYNRK APTKSSTRQT TLDGSISNTK KSSRTKKKKE
1260 1270 1280 1290 1300
EETNRGDETS PEGTVGEDEV EEEPRQAEPP KRALRSNSGK AASNKRTTRN
1310 1320 1330 1340 1350
SMKTHSAMDT LTAVAALDAE LDNMSNEKAK EEVDHVKSEN GESVNEPNTE
1360 1370
DLSLETEENT TVSDISPLVK NEA
Length:1,373
Mass (Da):158,549
Last modified:May 1, 2000 - v1
Checksum:i7ABAFA7BD4C2503B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68I → M in CAA67494 (PubMed:9520266).Curated1
Sequence conflicti133S → R in CAA67494 (PubMed:9520266).Curated1
Sequence conflicti225D → G in CAA67494 (PubMed:9520266).Curated1
Sequence conflicti339A → S in CAA67494 (PubMed:9520266).Curated1
Sequence conflicti385I → M in CAA67494 (PubMed:9520266).Curated1
Sequence conflicti479 – 489NIREYEFYLST → ILESM in CAA67494 (PubMed:9520266).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99021 Genomic DNA. Translation: CAA67494.1.
CU329670 Genomic DNA. Translation: CAB66168.1.
AB027852 Genomic DNA. Translation: BAA87156.1.
PIRiT43334.
T50107.
RefSeqiNP_593660.1. NM_001019092.2.

Genome annotation databases

EnsemblFungiiSPAC1783.05.1; SPAC1783.05.1:pep; SPAC1783.05.
GeneIDi2542363.
KEGGispo:SPAC1783.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99021 Genomic DNA. Translation: CAA67494.1.
CU329670 Genomic DNA. Translation: CAB66168.1.
AB027852 Genomic DNA. Translation: BAA87156.1.
PIRiT43334.
T50107.
RefSeqiNP_593660.1. NM_001019092.2.

3D structure databases

ProteinModelPortaliQ9US25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278827. 73 interactors.
IntActiQ9US25. 7 interactors.
MINTiMINT-4979817.

PTM databases

iPTMnetiQ9US25.

Proteomic databases

MaxQBiQ9US25.
PRIDEiQ9US25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1783.05.1; SPAC1783.05.1:pep; SPAC1783.05.
GeneIDi2542363.
KEGGispo:SPAC1783.05.

Organism-specific databases

EuPathDBiFungiDB:SPAC1783.05.
PomBaseiSPAC1783.05. hrp1.

Phylogenomic databases

HOGENOMiHOG000207917.
InParanoidiQ9US25.
KOiK11367.
OMAiGIKRVDN.
OrthoDBiEOG092C1YH4.
PhylomeDBiQ9US25.

Miscellaneous databases

PROiQ9US25.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR009057. Homeodomain-like.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRP1_SCHPO
AccessioniPrimary (citable) accession number: Q9US25
Secondary accession number(s): Q92369, Q9UU28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.