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Protein

Kinesin-like protein 2

Gene

klp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle. Required for the polarization of interphase microtubules where it orients the microtubule plus ends toward the cell ends and the minus ends toward the cell center. Mediates minus end-directed sliding of cytoplasmic microtubules relative to each other, thereby promoting mitotic spindle disassembly.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi563 – 570ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, minus-end-directed Source: PomBase
  • microtubule binding Source: PomBase

GO - Biological processi

  • cytoplasmic microtubule organization Source: PomBase
  • establishment or maintenance of microtubule cytoskeleton polarity Source: PomBase
  • karyogamy involved in conjugation with cellular fusion Source: PomBase
  • microtubule bundle formation Source: PomBase
  • microtubule sliding Source: PomBase
  • microtubule sliding involved in mitotic metaphase chromosome recapture Source: PomBase
  • minus-end directed microtubule sliding Source: PomBase
  • mitotic spindle elongation Source: PomBase
  • nuclear migration during mitotic telophase Source: PomBase

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 2
Gene namesi
Name:klp2
ORF Names:SPAC664.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC664.10
PomBaseiSPAC664.10 klp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253861 – 817Kinesin-like protein 2Add BLAST817

Proteomic databases

MaxQBiQ9US03
PaxDbiQ9US03
PRIDEiQ9US03

PTM databases

iPTMnetiQ9US03

Interactioni

GO - Molecular functioni

  • microtubule binding Source: PomBase

Protein-protein interaction databases

BioGridi279782, 13 interactors
STRINGi4896.SPAC664.10.1

Structurei

3D structure databases

ProteinModelPortaliQ9US03
SMRiQ9US03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini473 – 807Kinesin motorPROSITE-ProRule annotationAdd BLAST335

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 242Sequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 145Ser-richAdd BLAST138

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000116164
InParanoidiQ9US03
KOiK10405
OMAiCETARST
OrthoDBiEOG092C2D4G
PhylomeDBiQ9US03

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9US03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEGHKSLT SHLPQSSSSL SQSREIAKEF TSNIPPPTIK TNSSSSNILK
60 70 80 90 100
PRLSLQNEVN QLKPAKFPSK MLPPGSLASV KSSSLAKKAR PFTASSNPRM
110 120 130 140 150
PKSAHPISSR SVSASSHFGR PASAVSSSLN SSDDVRSMSD ESMESYNDEK
160 170 180 190 200
SVNASALRTT EDRLRSMEMA YAQLSAKVIP SPSKRPANYK FYEQRIAMLE
210 220 230 240 250
ESLEVERSRT SELQEQFSVA LREKAEAEAN KIVSQKGMES LEIMLNSMKS
260 270 280 290 300
ENHQRMAMLE ENHARVMETA ELQHQAELQD FASNIEQKAN SLIMEYKNEL
310 320 330 340 350
QSAEEHFSHK IKELTSENEL KISRLQEEKD SLLKKVQEGA SLAMQRVQNK
360 370 380 390 400
HDLEKKRLQS AIQPLQEENN SLKQQIEQLQ RELASETVVK ENLKSSLDQQ
410 420 430 440 450
SANVQKLEST NRALESTIKT LEEDVYTMKN KIIELEGILK SANVERDGLV
460 470 480 490 500
EKLIAEETLR RKLHNTIQEL KGNIRVFCRV RPPLGDGESA QIAFPDQNSE
510 520 530 540 550
ASTIEIVAQA PGSSLTGNGI KQYAFNFDRV FSPETTNEDV FNELSQLIQS
560 570 580 590 600
AMDGYNVCIF AYGQTGSGKT HTMSSNTGMI PSSVRMIYNR STSLKERGWE
610 620 630 640 650
YRMEGQFLEI YNETIIDLLA SGNEEEKGKK KLEIYHDTKA GRTTITNITS
660 670 680 690 700
EPLDTPEQVT WLLDQASKNR SVAATNANEH SSRSHSVFML HLNGSNSTTG
710 720 730 740 750
ETCRSTLNLI DLAGSERLSS SQSVGERLKE TQAINKSLSC LGDVIHALGS
760 770 780 790 800
GKEGTYIPYR NSKLTNLLQY SLGGNSKTLM FVNISPLKQH VPETLCSLRF
810
ATKVNNTQIG TARKVTK
Length:817
Mass (Da):91,043
Last modified:May 1, 2000 - v1
Checksum:i804677851AF1A52D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB65811.1
PIRiT50240
RefSeqiNP_593458.1, NM_001018891.2

Genome annotation databases

EnsemblFungiiSPAC664.10.1; SPAC664.10.1:pep; SPAC664.10
GeneIDi2543360
KEGGispo:SPAC664.10

Similar proteinsi

Entry informationi

Entry nameiKLP2_SCHPO
AccessioniPrimary (citable) accession number: Q9US03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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