Reviewed, UniProtKB/Swiss-Prot Q9URZ7 (YK72_SCHPO)

Names and origin

Protein names

Recommended name:
    Probable fructose-2,6-bisphosphatase C732.02c
    EC=3.1.3.46

Gene names

ORF Names:

SPAC732.02c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This is predominantly if not solely a fructose-2,6-bisphosphatase By similarity.
Catalytic activity	Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
Sequence similarities	In the C-terminal section; belongs to the phosphoglycerate mutase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fructose 2,6-bisphosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphofructo-2-kinase activity Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fructose-2,6-bisphosphate 2-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Probable fructose-2,6-bisphosphatase C732.02c		PRO_0000318495
Regions
	Nucleotide binding	16 – 23	8	ATP By similarity
Sites
	Active site	88	1	Potential
	Active site	214	1	Tele-phosphohistidine intermediate By similarity
	Active site	285	1	By similarity
	Active site	350	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9URZ7-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0C7CB4B083861F90	FASTA	408	46,948
	10 20 30 40 50 60 MKDIEGLLGL CVCFVGLPAS GKTSSAMKLS RYLTWMSVST HLYDTKEIDN SLSENSNSDS 70 80 90 100 110 120 ENLAKTLSPI FDNLESVFKK GTDVAILDFN QCTLKFRKSI VELAKARNML LMFVEVVCTN 130 140 150 160 170 180 QKIIDENITD MCQHSPYFKS FPFEESKNKI LDSIHEYEKH YTPLSEAEEC TFVRIVDFGA 190 200 210 220 230 240 ELIVHKLENY LESRIVYYLS NLRTRRRSIW LSRHGESQFN VEGKIGGDSS LSPQGLKYAA 250 260 270 280 290 300 LLPEYVAKFS IGEKGLTVWT SSMARTIQTA RHLNCQKLEW RALDELDAGT CDGFTYDYIE 310 320 330 340 350 360 QNFPHEAELR NNDKFHYRYR GGESYMDVVR RLEPIIMELE RQGDVFIICH QAILRCIYGY 370 380 390 400 YHNLSLEELP FINVPLHTII KLTPMTYETI EERVTVPISA VSTQRGKH

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB62425.1.
PIR	T50254.
RefSeq	NP_593601.1.
3D structure databases
HSSP	HSSP built from PDB template 1C80 based on UniProtKB P07953.
ModBase	Search...
Genome annotation databases
GeneID	2541800.
KEGG	spo:SPAC732.02c.
NMPDR	fig|4896.1.peg.3571.
Organism-specific databases
GeneDB_Spombe	SPAC732.02c.
Phylogenomic databases
OMA	Q9URZ7. TYREKPK.
Enzyme and pathway databases
BRENDA	3.1.3.46. 653.
Gene expression databases
ArrayExpress	Q9URZ7.
Family and domain databases
InterPro	IPR003094. 6Pfruct_kin. IPR013079. 6Phosfructo_kin. IPR016260. Bifunct_6PFK/fruc_bisP_Ptase. IPR001345. PG/BPGM_mutase. IPR013078. PG_mutase. [Graphical view]
PANTHER	PTHR10606. 6Pfruct_kin. 1 hit.
Pfam	PF01591. 6PF2K. 2 hits. PF00300. PGAM. 1 hit. [Graphical view]
PIRSF	PIRSF000709. 6PFK_2-Ptase. 1 hit.
PRINTS	PR00991. 6PFRUCTKNASE.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YK72_SCHPO

Accession

Primary (citable) accession number: Q9URZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)