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Protein

Protein arginine N-methyltransferase 1

Gene

rmt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in target proteins (By similarity). Asymmetrically dimethylates the polyadenylate-binding protein pab2, modulating pab2 oligomerization (PubMed:17213188).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29S-adenosyl-L-methionineBy similarity1
Binding sitei38S-adenosyl-L-methionineBy similarity1
Binding sitei62S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei84S-adenosyl-L-methionineBy similarity1
Binding sitei113S-adenosyl-L-methionineBy similarity1
Active sitei128By similarity1
Active sitei137By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-SPO-3214858 RMTs methylate histone arginines
R-SPO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 11 Publication (EC:2.1.1.-By similarity)
Alternative name(s):
Type I protein arginine N-methyltransferaseBy similarity
Short name:
Type I PRMTBy similarity
Gene namesi
Name:rmt11 Publication
ORF Names:SPAC890.07cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC890.07c
PomBaseiSPAC890.07c rmt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123371 – 340Protein arginine N-methyltransferase 1Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Phosphotyrosine1 Publication1
Modified residuei176Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9URX7
PaxDbiQ9URX7
PRIDEiQ9URX7

PTM databases

iPTMnetiQ9URX7

Interactioni

Subunit structurei

Interacts with pab2.1 Publication

Protein-protein interaction databases

BioGridi279912, 2 interactors
STRINGi4896.SPAC890.07c.1

Structurei

3D structure databases

ProteinModelPortaliQ9URX7
SMRiQ9URX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 311SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST296

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000198521
InParanoidiQ9URX7
KOiK11434
OMAiRFSTGPH
OrthoDBiEOG092C393Q
PhylomeDBiQ9URX7

Family and domain databases

InterProiView protein in InterPro
IPR025799 Arg_MeTrfase
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51678 SAM_MT_PRMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9URX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGNTKKSAD SGLTAKDYYF DSYSHWGIHE EMLKDDVRTL SYRDAIMQNP
60 70 80 90 100
HLFRDKIVLD VGCGTGILSM FCARAGAKHV YGVDMSEIIH KAVQIVEVNK
110 120 130 140 150
LSDRITLIQG KMEEIQLPVE KVDIIVSEWM GYFLLYESML DTVLVARDRY
160 170 180 190 200
LAPDGLLFPD RAQIQLAAIE DADYKSEKIG FWDDVYGFDF SPIKKDVWKE
210 220 230 240 250
PLVDTVDRIA VNTNSCVILD LDLKTVKKED LAFSSPFEIT ATRNDFVHAF
260 270 280 290 300
LAWFDIEFSA CHKPIKFSTG PFSRYTHWKQ TVFYTHKDLT VKAGEYIRGT
310 320 330 340
ITCKPAEGNH RELDIDISYT FNPREPNREP VSEDLSYRMC
Length:340
Mass (Da):39,019
Last modified:September 22, 2009 - v2
Checksum:i7302B4988ED5E176
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB63498.2
PIRiT50263
RefSeqiNP_594825.2, NM_001020254.3

Genome annotation databases

EnsemblFungiiSPAC890.07c.1; SPAC890.07c.1:pep; SPAC890.07c
GeneIDi2543492
KEGGispo:SPAC890.07c

Similar proteinsi

Entry informationi

Entry nameiANM1_SCHPO
AccessioniPrimary (citable) accession number: Q9URX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: September 22, 2009
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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