Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sulfiredoxin

Gene

srx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.1 Publication

Catalytic activityi

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • sulfiredoxin activity Source: PomBase

GO - Biological processi

  • cellular protein localization Source: PomBase
  • cellular response to oxidative stress Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfiredoxin (EC:1.8.98.2)
Gene namesi
Name:srx1
ORF Names:SPBC106.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC106.02c.
PomBaseiSPBC106.02c. srx1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114341 – 124SulfiredoxinAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9URV9.
PRIDEiQ9URV9.

Interactioni

Subunit structurei

Interacts with tpx1 in response to oxidative stress.1 Publication

Protein-protein interaction databases

BioGridi276607. 3 interactors.
MINTiMINT-4707090.

Structurei

3D structure databases

ProteinModelPortaliQ9URV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfiredoxin family.Curated

Phylogenomic databases

HOGENOMiHOG000231799.
InParanoidiQ9URV9.
KOiK12260.
OMAiCHRFEAY.
OrthoDBiEOG092C1W6S.
PhylomeDBiQ9URV9.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 1 hit.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9URV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIHTGSNN NIVELDMSEL IRPIPPVLDM NKVNSMMETM TGKTPPASCG
60 70 80 90 100
LTSEDLEAGE LPPVDVLTFK KSGKPYYFAF GGCHRLRAHD EAGRKKVRCK
110 120
LVNCSPNTLR LYLGASANKF LDSD
Length:124
Mass (Da):13,603
Last modified:May 1, 2000 - v1
Checksum:iFE34FE87ADF3EA64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB53718.1.
PIRiT39259.
RefSeqiNP_595151.1. NM_001021060.2.

Genome annotation databases

EnsemblFungiiSPBC106.02c.1; SPBC106.02c.1:pep; SPBC106.02c.
GeneIDi2540069.
KEGGispo:SPBC106.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB53718.1.
PIRiT39259.
RefSeqiNP_595151.1. NM_001021060.2.

3D structure databases

ProteinModelPortaliQ9URV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276607. 3 interactors.
MINTiMINT-4707090.

Proteomic databases

MaxQBiQ9URV9.
PRIDEiQ9URV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC106.02c.1; SPBC106.02c.1:pep; SPBC106.02c.
GeneIDi2540069.
KEGGispo:SPBC106.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC106.02c.
PomBaseiSPBC106.02c. srx1.

Phylogenomic databases

HOGENOMiHOG000231799.
InParanoidiQ9URV9.
KOiK12260.
OMAiCHRFEAY.
OrthoDBiEOG092C1W6S.
PhylomeDBiQ9URV9.

Miscellaneous databases

PROiQ9URV9.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 1 hit.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSRX1_SCHPO
AccessioniPrimary (citable) accession number: Q9URV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.