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Protein

Sulfiredoxin

Gene

srx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.1 Publication

Catalytic activityi

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • sulfiredoxin activity Source: PomBase

GO - Biological processi

  • cellular detoxification Source: PomBase
  • cellular oxidant detoxification Source: GOC
  • cellular protein localization Source: PomBase
  • cellular response to oxidative stress Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfiredoxin (EC:1.8.98.2)
Gene namesi
Name:srx1
ORF Names:SPBC106.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC106.02c.
PomBaseiSPBC106.02c. srx1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124SulfiredoxinPRO_0000211434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 – 83InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9URV9.

Interactioni

Subunit structurei

Interacts with tpx1 in response to oxidative stress.1 Publication

Protein-protein interaction databases

BioGridi276607. 3 interactions.
MINTiMINT-4707090.

Structurei

3D structure databases

ProteinModelPortaliQ9URV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfiredoxin family.Curated

Phylogenomic databases

HOGENOMiHOG000231799.
InParanoidiQ9URV9.
KOiK12260.
OMAiCHRFEAY.
OrthoDBiEOG7MKWG5.
PhylomeDBiQ9URV9.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 1 hit.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9URV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIHTGSNN NIVELDMSEL IRPIPPVLDM NKVNSMMETM TGKTPPASCG
60 70 80 90 100
LTSEDLEAGE LPPVDVLTFK KSGKPYYFAF GGCHRLRAHD EAGRKKVRCK
110 120
LVNCSPNTLR LYLGASANKF LDSD
Length:124
Mass (Da):13,603
Last modified:May 1, 2000 - v1
Checksum:iFE34FE87ADF3EA64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB53718.1.
PIRiT39259.
RefSeqiNP_595151.1. NM_001021060.2.

Genome annotation databases

EnsemblFungiiSPBC106.02c.1; SPBC106.02c.1:pep; SPBC106.02c.
GeneIDi2540069.
KEGGispo:SPBC106.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB53718.1.
PIRiT39259.
RefSeqiNP_595151.1. NM_001021060.2.

3D structure databases

ProteinModelPortaliQ9URV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276607. 3 interactions.
MINTiMINT-4707090.

Proteomic databases

MaxQBiQ9URV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC106.02c.1; SPBC106.02c.1:pep; SPBC106.02c.
GeneIDi2540069.
KEGGispo:SPBC106.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC106.02c.
PomBaseiSPBC106.02c. srx1.

Phylogenomic databases

HOGENOMiHOG000231799.
InParanoidiQ9URV9.
KOiK12260.
OMAiCHRFEAY.
OrthoDBiEOG7MKWG5.
PhylomeDBiQ9URV9.

Miscellaneous databases

PROiQ9URV9.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 1 hit.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide."
    Bozonet S.M., Findlay V.J., Day A.M., Cameron J., Veal E.A., Morgan B.A.
    J. Biol. Chem. 280:23319-23327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TPX1.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSRX1_SCHPO
AccessioniPrimary (citable) accession number: Q9URV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.