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Protein

Sulfiredoxin

Gene

srx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.1 Publication

Catalytic activityi

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • sulfiredoxin activity Source: PomBase

GO - Biological processi

  • cellular detoxification Source: PomBase
  • cellular protein localization Source: PomBase
  • cellular response to oxidative stress Source: PomBase

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfiredoxin (EC:1.8.98.2)
Gene namesi
Name:srx1
ORF Names:SPBC106.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPBC106.02c
PomBaseiSPBC106.02c srx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114341 – 124SulfiredoxinAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9URV9
PaxDbiQ9URV9
PRIDEiQ9URV9

PTM databases

iPTMnetiQ9URV9

Interactioni

Subunit structurei

Interacts with tpx1 in response to oxidative stress.1 Publication

Protein-protein interaction databases

BioGridi276607, 4 interactors
STRINGi4896.SPBC106.02c.1

Structurei

3D structure databases

ProteinModelPortaliQ9URV9
SMRiQ9URV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfiredoxin family.Curated

Phylogenomic databases

HOGENOMiHOG000231799
InParanoidiQ9URV9
KOiK12260
OMAiGGCHRFA
OrthoDBiEOG092C1W6S
PhylomeDBiQ9URV9

Family and domain databases

InterProiView protein in InterPro
IPR003115 ParB/Sulfiredoxin_dom
IPR036086 ParB/Sulfiredoxin_sf
IPR016692 Sulfiredoxin
PANTHERiPTHR21348 PTHR21348, 1 hit
PfamiView protein in Pfam
PF02195 ParBc, 1 hit
PIRSFiPIRSF017267 Sulfiredoxin, 1 hit
SMARTiView protein in SMART
SM00470 ParB, 1 hit
SUPFAMiSSF110849 SSF110849, 1 hit

Sequencei

Sequence statusi: Complete.

Q9URV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIHTGSNN NIVELDMSEL IRPIPPVLDM NKVNSMMETM TGKTPPASCG
60 70 80 90 100
LTSEDLEAGE LPPVDVLTFK KSGKPYYFAF GGCHRLRAHD EAGRKKVRCK
110 120
LVNCSPNTLR LYLGASANKF LDSD
Length:124
Mass (Da):13,603
Last modified:May 1, 2000 - v1
Checksum:iFE34FE87ADF3EA64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB53718.1
PIRiT39259
RefSeqiNP_595151.1, NM_001021060.2

Genome annotation databases

EnsemblFungiiSPBC106.02c.1; SPBC106.02c.1:pep; SPBC106.02c
GeneIDi2540069
KEGGispo:SPBC106.02c

Similar proteinsi

Entry informationi

Entry nameiSRX1_SCHPO
AccessioniPrimary (citable) accession number: Q9URV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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