Q9URV1 (PLG7_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative phospholipase A2
EC=3.1.1.47

Alternative name(s):
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase

Gene names

Name:	plg7
ORF Names:	SPBC106.11c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. UniProtKB Q13093 UniProtKB P83006
Subcellular location	Cytoplasm. Nucleus Ref.2.
Sequence similarities	Belongs to the serine esterase family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to oxidative stress Inferred from mutant phenotype PubMed 18489912. Source: PomBase phospholipid catabolic process Inferred from mutant phenotype PubMed 18489912. Source: PomBase
Cellular_component	cytosol Inferred from direct assay Ref.2. Source: PomBase nucleus Inferred from direct assay Ref.2. Source: PomBase
Molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity Inferred from mutant phenotype PubMed 18489912. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Putative phospholipase A2		PRO_0000316918
Sites
	Active site	257	1	Nucleophile By similarity UniProtKB Q13093
	Active site	291	1	Charge relay system By similarity UniProtKB Q13093
	Active site	368	1	Charge relay system By similarity UniProtKB Q13093

Sequences

	Sequence		Length	Mass (Da)
	Q9URV1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 24767654F94C10F9	FASTA	438	49,847
	10 20 30 40 50 60 MGLGFSSKKQ LPAYCGPLPV GSLVLELSVP EEFRCEYKTI EHKLRTVKVR IFYPLDPTKD 70 80 90 100 110 120 VEPRTDELWL PFHEGIPEVA KGFRWWLLRA FASGLTNLAL PVYKGELFHP PNNGKLPVFI 130 140 150 160 170 180 FSHGLVGSRN VYSSLCGTIA SYGIVVLAME HRDNSAIIST VRDPLHPEEP PYVVQYREIS 190 200 210 220 230 240 DFYADATVVL QNERLLFRQQ EIQIALQMIR NINDLGTPDE NLPFLCSVDS SFYNSVFQSM 250 260 270 280 290 300 KGNLNTAQGE LIVAGHSFGA ATCAFISGSS TKSLYNDYMF HTEFKCSILY DIWMLPVRQL 310 320 330 340 350 360 HLSTMRYPTL MIISYEFRRF VDNFQALESW LVNKDSENQN AGESADEKMS VVPLKKYSHV 370 380 390 400 410 420 FVYDGTVHAN QSDLPILLPR MVLRVLKGKF EADPYEALRI NTRSSVQFLR ENHVENVQGD 430 NDPSSLQTNI IPGWERIM

References

[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAB53727.1.
PIR	T39268.
RefSeq	NP_595160.1. NM_001021069.2.
3D structure databases
ProteinModelPortal	Q9URV1.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPBC106.11c-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBC106.11c.1; SPBC106.11c.1:pep; SPBC106.11c.
GeneID	2539799.
KEGG	spo:SPBC106.11c.
Organism-specific databases
PomBase	SPBC106.11c.
Phylogenomic databases
eggNOG	NOG286523.
KO	K01062.
OMA	RNAYSHI.
OrthoDB	EOG428591.
Family and domain databases
InterPro	IPR016715. Ac_Ohase_PAF. IPR005065. PAF_acetylhydro. [Graphical view]
PANTHER	PTHR10272. PTHR10272. 1 hit.
Pfam	PF03403. PAF-AH_p_II. 1 hit. [Graphical view]
PIRSF	PIRSF018169. PAF_acetylhydrolase. 1 hit.
PROSITE	PS00120. LIPASE_SER. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20800948.

Entry information

Entry name

PLG7_SCHPO

Accession

Primary (citable) accession number: Q9URV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program