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Protein

Putative phospholipase A2

Gene

plg7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571NucleophileBy similarity
Active sitei291 – 2911Charge relay systemBy similarity
Active sitei368 – 3681Charge relay systemBy similarity

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: PomBase

GO - Biological processi

  1. cellular response to oxidative stress Source: PomBase
  2. phospholipid catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phospholipase A2 (EC:3.1.1.47)
Alternative name(s):
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase
Gene namesi
Name:plg7Imported
ORF Names:SPBC106.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome II

Organism-specific databases

PomBaseiSPBC106.11c.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Putative phospholipase A2PRO_0000316918Add
BLAST

Proteomic databases

MaxQBiQ9URV1.

Interactioni

Protein-protein interaction databases

BioGridi276349. 4 interactions.
MINTiMINT-4707043.
STRINGi4896.SPBC106.11c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9URV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serine esterase family.Sequence Analysis

Phylogenomic databases

eggNOGiNOG286523.
InParanoidiQ9URV1.
KOiK01062.
OMAiKSKWITH.
OrthoDBiEOG73BVNJ.
PhylomeDBiQ9URV1.

Family and domain databases

Gene3Di3.40.50.1820. 4 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9URV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLGFSSKKQ LPAYCGPLPV GSLVLELSVP EEFRCEYKTI EHKLRTVKVR
60 70 80 90 100
IFYPLDPTKD VEPRTDELWL PFHEGIPEVA KGFRWWLLRA FASGLTNLAL
110 120 130 140 150
PVYKGELFHP PNNGKLPVFI FSHGLVGSRN VYSSLCGTIA SYGIVVLAME
160 170 180 190 200
HRDNSAIIST VRDPLHPEEP PYVVQYREIS DFYADATVVL QNERLLFRQQ
210 220 230 240 250
EIQIALQMIR NINDLGTPDE NLPFLCSVDS SFYNSVFQSM KGNLNTAQGE
260 270 280 290 300
LIVAGHSFGA ATCAFISGSS TKSLYNDYMF HTEFKCSILY DIWMLPVRQL
310 320 330 340 350
HLSTMRYPTL MIISYEFRRF VDNFQALESW LVNKDSENQN AGESADEKMS
360 370 380 390 400
VVPLKKYSHV FVYDGTVHAN QSDLPILLPR MVLRVLKGKF EADPYEALRI
410 420 430
NTRSSVQFLR ENHVENVQGD NDPSSLQTNI IPGWERIM
Length:438
Mass (Da):49,847
Last modified:May 1, 2000 - v1
Checksum:i24767654F94C10F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB53727.1.
PIRiT39268.
RefSeqiNP_595160.1. NM_001021069.2.

Genome annotation databases

EnsemblFungiiSPBC106.11c.1; SPBC106.11c.1:pep; SPBC106.11c.
GeneIDi2539799.
KEGGispo:SPBC106.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB53727.1.
PIRiT39268.
RefSeqiNP_595160.1. NM_001021069.2.

3D structure databases

ProteinModelPortaliQ9URV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276349. 4 interactions.
MINTiMINT-4707043.
STRINGi4896.SPBC106.11c-1.

Proteomic databases

MaxQBiQ9URV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC106.11c.1; SPBC106.11c.1:pep; SPBC106.11c.
GeneIDi2539799.
KEGGispo:SPBC106.11c.

Organism-specific databases

PomBaseiSPBC106.11c.

Phylogenomic databases

eggNOGiNOG286523.
InParanoidiQ9URV1.
KOiK01062.
OMAiKSKWITH.
OrthoDBiEOG73BVNJ.
PhylomeDBiQ9URV1.

Miscellaneous databases

NextBioi20800948.

Family and domain databases

Gene3Di3.40.50.1820. 4 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPLG7_SCHPO
AccessioniPrimary (citable) accession number: Q9URV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.