Reviewed, UniProtKB/Swiss-Prot Q9URT4 (AMS2_SCHPO)

Names and origin

Protein names

Recommended name:
    CENP-A multicopy suppressor protein 2

Gene names

Name:	ams2
ORF Names:	SPCC290.04, SPCC4F11.01

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	697 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for proper chromosome segregation via regulation of CENP-A localization to the centromere. Ref.2
Subunit structure	Interacts with CENP-A. Ref.2
Subcellular location	Nucleus. Centromere.
Sequence similarities	Contains 1 GATA-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Centromere Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	CenH3-containing nucleosome assembly at centromere Traceable author statement. Source: GeneDB_SPombe cellular protein localization Ref.2 Inferred from genetic interaction. Source: GeneDB_SPombe chromosome segregation Ref.2 Inferred from mutant phenotype. Source: GeneDB_SPombe regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, centromeric region Ref.2 Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	centromeric DNA binding Ref.2 Inferred from direct assay. Source: GeneDB_SPombe transcription factor activity Ref.2 Traceable author statement. Source: GeneDB_SPombe zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 697	697	CENP-A multicopy suppressor protein 2		PRO_0000083474
Regions
	Zinc finger	351 – 378	28	GATA-type; atypical

Sequences

	Sequence		Length	Mass (Da)
	Q9URT4-1 [UniParc]. Last modified May 16, 2003. Version 2. Checksum: 37E68D8232C1C069	FASTA	697	78,160
	10 20 30 40 50 60 MMEKSLNTVT SLPLRVIYCI DRASAIRCLA KSQHAVPIQV LKEVEPKKVI CQVDIQHVIQ 70 80 90 100 110 120 TVCRCSPELS CKSQGDFSVY FLDHTEPDEL FVGLGYWSSL LLSPTLNAGT SNSDTVWVNG 130 140 150 160 170 180 FIVEFGIQRS IEIKLRFQSL QNSFEVGTPE THTSSKFLSS TLPPSLIFDP SSSEKSDSIS 190 200 210 220 230 240 GSLFDTNYTC PVNINGLSKQ KSVRELKSPS RPSALAETNV EELELDSLFH ASNDISCSAT 250 260 270 280 290 300 SFSEPYILDH QAALDHPATD PVCSASSTTV NSAVSTKKRR RESSTISPES AYVAAQLQNP 310 320 330 340 350 360 SEREQVHEFI KEQVRIARGR IEKKFTNVRG KNRIEEQLTL SLQEGKIPPY CQNCGTIKTA 370 380 390 400 410 420 NWRNATYMNI TLMLCNACGI YWTSRRSMRP RNLWSTYKAF ETEKPLENDA FAQLELAVYK 430 440 450 460 470 480 LSQQRKLSIS IFRELENAGR HSPLNRLTSL DSTHSAPDPN HISKPSVVNQ QKSRGGPRTA 490 500 510 520 530 540 KLKNDLRRIQ SSPIVAPTPD TSFREPLSEI GSNDSWLVLP NSLSANIQND VLRKTDFMCT 550 560 570 580 590 600 DKENVAFPLK TTTKPMPKVN KEETEPTLPV CDSEKENDDL ECYFRTPPKP TTLQKQQQSP 610 620 630 640 650 660 SPWRSELFLS DPDQNVLTPR HKPKFDLSKA LSSVAKSNNI ENSPQLPERY DFSLELGLNS 670 680 690 QLDNEERRDI PLMTDLVMPS SPPMVPADRH LSVENTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast." Chen E.S., Saitoh S., Yanagida M., Takahashi K. Mol. Cell 11:175-187(2003) [PubMed: 12535531] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329672 Genomic DNA. Translation: CAB61504.1.
PIR	T41352.
RefSeq	NP_588400.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9URT4.
Genome annotation databases
GeneID	2539242.
GenomeReviews	Gene locus ams2 in contig CU329672_GR.
KEGG	spo:SPCC290.04.
Organism-specific databases
GeneDB_Spombe	SPCC290.04.
Phylogenomic databases
OrthoDB	EOG9N5XD2
Gene expression databases
ArrayExpress	Q9URT4.
Family and domain databases
InterPro	IPR000679. Znf_GATA. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00320. GATA. 1 hit. [Graphical view]
PROSITE	PS00344. GATA_ZN_FINGER_1. 1 hit. PS50114. GATA_ZN_FINGER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMS2_SCHPO

Accession

Primary (citable) accession number: Q9URT4
Secondary accession number(s): Q9P7Z1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	May 16, 2003
Last modified:	November 24, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)