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Protein

NADP-specific glutamate dehydrogenase

Gene

GDH

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:GDH
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461NADP-specific glutamate dehydrogenasePRO_0000182793Add
BLAST

Proteomic databases

PRIDEiQ9URS1.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi500485.XP_002565667.1.

Structurei

3D structure databases

ProteinModelPortaliQ9URS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

PhylomeDBiQ9URS1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9URS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQNLPFEPE FEQAYKELAS TLENSTLFQK KPEYRKALQV VSVPERVIQF
60 70 80 90 100
RVVWEDDKGQ VQINRGYRVQ FNSALGPYKG GLRFHPTVNL SILKFLGFEQ
110 120 130 140 150
IFKNALTGLN MGGGKGGSDF DPKGKTDNEI RRFCVSFMTE LCKHIGADTD
160 170 180 190 200
VPAGDIGVTG REVGFMFGQY KKIRNQWEGV LTGKGGSWGG SLIRPEATGY
210 220 230 240 250
GVVYYVEHMI QHASGGKESF AGKRVAISGS GNVAQYAALK VIELGGSVIS
260 270 280 290 300
LSDSQGALVL NGEEGSFTAE EINTIAEIKV QRKQIAELAT QDAFSSKFKY
310 320 330 340 350
IPGARPWTNI AGRIDVALPS ATQNEVSGDE AKALIAAGCK FIAEGSNMGS
360 370 380 390 400
TQEAIDVFEA HRDANPGAAA IWYAPGKAAN AGGVAVSGLE MAQNSARVNW
410 420 430 440 450
SREEVDSRLK KIMEDCFNNG LSTAKEYVTP AEGVLPSLVA GSNIAGFTKV
460
AEAMKEHGDW W
Length:461
Mass (Da):49,832
Last modified:May 1, 2000 - v1
Checksum:i76A014A29150B4DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056974 Genomic DNA. Translation: AAF00006.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056974 Genomic DNA. Translation: AAF00006.1.

3D structure databases

ProteinModelPortaliQ9URS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002565667.1.

Proteomic databases

PRIDEiQ9URS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

PhylomeDBiQ9URS1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The NADP-dependent glutamate dehydrogenase gene from Penicillium chrysogenum and the construction of expression vectors for filamentous fungi."
    Diez B., Mellado E., Rodriguez M., Bernasconi E., Barredo J.L.
    Appl. Microbiol. Biotechnol. 52:196-207(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE4_PENCH
AccessioniPrimary (citable) accession number: Q9URS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.