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Q9URS1

- DHE4_PENCH

UniProt

Q9URS1 - DHE4_PENCH

Protein

NADP-specific glutamate dehydrogenase

Gene

GDH

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei115 – 1151PROSITE-ProRule annotation

    GO - Molecular functioni

    1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
    Short name:
    NADP-GDH
    Alternative name(s):
    NADP-dependent glutamate dehydrogenase
    Gene namesi
    Name:GDH
    OrganismiPenicillium chrysogenum (Penicillium notatum)
    Taxonomic identifieri5076 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461NADP-specific glutamate dehydrogenasePRO_0000182793Add
    BLAST

    Proteomic databases

    PRIDEiQ9URS1.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9URS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    PhylomeDBiQ9URS1.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9URS1-1 [UniParc]FASTAAdd to Basket

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    MMQNLPFEPE FEQAYKELAS TLENSTLFQK KPEYRKALQV VSVPERVIQF    50
    RVVWEDDKGQ VQINRGYRVQ FNSALGPYKG GLRFHPTVNL SILKFLGFEQ 100
    IFKNALTGLN MGGGKGGSDF DPKGKTDNEI RRFCVSFMTE LCKHIGADTD 150
    VPAGDIGVTG REVGFMFGQY KKIRNQWEGV LTGKGGSWGG SLIRPEATGY 200
    GVVYYVEHMI QHASGGKESF AGKRVAISGS GNVAQYAALK VIELGGSVIS 250
    LSDSQGALVL NGEEGSFTAE EINTIAEIKV QRKQIAELAT QDAFSSKFKY 300
    IPGARPWTNI AGRIDVALPS ATQNEVSGDE AKALIAAGCK FIAEGSNMGS 350
    TQEAIDVFEA HRDANPGAAA IWYAPGKAAN AGGVAVSGLE MAQNSARVNW 400
    SREEVDSRLK KIMEDCFNNG LSTAKEYVTP AEGVLPSLVA GSNIAGFTKV 450
    AEAMKEHGDW W 461
    Length:461
    Mass (Da):49,832
    Last modified:May 1, 2000 - v1
    Checksum:i76A014A29150B4DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF056974 Genomic DNA. Translation: AAF00006.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF056974 Genomic DNA. Translation: AAF00006.1 .

    3D structure databases

    ProteinModelPortali Q9URS1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9URS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    PhylomeDBi Q9URS1.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The NADP-dependent glutamate dehydrogenase gene from Penicillium chrysogenum and the construction of expression vectors for filamentous fungi."
      Diez B., Mellado E., Rodriguez M., Bernasconi E., Barredo J.L.
      Appl. Microbiol. Biotechnol. 52:196-207(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiDHE4_PENCH
    AccessioniPrimary (citable) accession number: Q9URS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3