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Q9URS1 (DHE4_PENCH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene names
Name:GDH
OrganismPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifier5076 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461NADP-specific glutamate dehydrogenase
PRO_0000182793

Sites

Active site1151 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9URS1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 76A014A29150B4DE

FASTA46149,832
        10         20         30         40         50         60 
MMQNLPFEPE FEQAYKELAS TLENSTLFQK KPEYRKALQV VSVPERVIQF RVVWEDDKGQ 

        70         80         90        100        110        120 
VQINRGYRVQ FNSALGPYKG GLRFHPTVNL SILKFLGFEQ IFKNALTGLN MGGGKGGSDF 

       130        140        150        160        170        180 
DPKGKTDNEI RRFCVSFMTE LCKHIGADTD VPAGDIGVTG REVGFMFGQY KKIRNQWEGV 

       190        200        210        220        230        240 
LTGKGGSWGG SLIRPEATGY GVVYYVEHMI QHASGGKESF AGKRVAISGS GNVAQYAALK 

       250        260        270        280        290        300 
VIELGGSVIS LSDSQGALVL NGEEGSFTAE EINTIAEIKV QRKQIAELAT QDAFSSKFKY 

       310        320        330        340        350        360 
IPGARPWTNI AGRIDVALPS ATQNEVSGDE AKALIAAGCK FIAEGSNMGS TQEAIDVFEA 

       370        380        390        400        410        420 
HRDANPGAAA IWYAPGKAAN AGGVAVSGLE MAQNSARVNW SREEVDSRLK KIMEDCFNNG 

       430        440        450        460 
LSTAKEYVTP AEGVLPSLVA GSNIAGFTKV AEAMKEHGDW W 

« Hide

References

[1]"The NADP-dependent glutamate dehydrogenase gene from Penicillium chrysogenum and the construction of expression vectors for filamentous fungi."
Diez B., Mellado E., Rodriguez M., Bernasconi E., Barredo J.L.
Appl. Microbiol. Biotechnol. 52:196-207(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF056974 Genomic DNA. Translation: AAF00006.1.

3D structure databases

ProteinModelPortalQ9URS1.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9URS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

PhylomeDBQ9URS1.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_PENCH
AccessionPrimary (citable) accession number: Q9URS1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: November 13, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families