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Protein

High temperature lethal protein 1

Gene

HTL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cell cycle progression through G2/M transition at temperatures higher than 33 degrees Celsius. Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. When associated with the RSC complex, may act coordinately with PKC1 to regulate G2/M transition. Together with LDB7, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity.3 Publications

Miscellaneous

Present with 3550 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • chromatin remodeling Source: SGD
  • G2/M transition of mitotic cell cycle Source: UniProtKB
  • nucleosome disassembly Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription elongation from RNA polymerase II promoter Source: SGD

Keywordsi

Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29401-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
High temperature lethal protein 1
Alternative name(s):
Chromatin structure-remodeling complex protein HTL1
Gene namesi
Name:HTL1
Synonyms:DRT1
Ordered Locus Names:YCR020W-B
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR020W-B
SGDiS000006439 HTL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000840852 – 78High temperature lethal protein 1Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9URQ5
PaxDbiQ9URQ5
PRIDEiQ9URQ5

PTM databases

iPTMnetiQ9URQ5

Interactioni

Subunit structurei

Interacts directly with RSC8. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of a fungal-specific module (HTL1-LDB7-NPL6-RSC3-RSC30) within the RSC complex.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31003, 117 interactors
IntActiQ9URQ5, 21 interactors
MINTiQ9URQ5
STRINGi4932.YCR020W-B

Structurei

3D structure databases

ProteinModelPortaliQ9URQ5
SMRiQ9URQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000000899
InParanoidiQ9URQ5
KOiK11769
OMAiQRENICE
OrthoDBiEOG092C5U32

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9URQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNNTISSM NPERAYNNVT LKNLTAFQLL SQRENICELL NLVESTERHN
60 70
SIINPERQRM SLEEMKKMLD ALKNERKK
Length:78
Mass (Da):9,180
Last modified:May 1, 2000 - v1
Checksum:i62308D5A1F6322C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162267 Genomic DNA Translation: AAD47275.1
X59720 Genomic DNA Translation: CAC42974.1
AY558371 Genomic DNA Translation: AAS56697.1
BK006937 Genomic DNA Translation: DAA07499.1
PIRiS07696
RefSeqiNP_009949.1, NM_001184313.1

Genome annotation databases

EnsemblFungiiCAC42974; CAC42974; CAC42974
YCR020W-B; YCR020W-B; YCR020W-B
GeneIDi850384
KEGGisce:YCR020W-B

Similar proteinsi

Entry informationi

Entry nameiHTL1_YEAST
AccessioniPrimary (citable) accession number: Q9URQ5
Secondary accession number(s): D6VR30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

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